Clinical trials · Boston, MA
Multiple sclerosis clinical trials in Boston
We’re tracking 26 recruiting multiple sclerosis studies with a site in or near Boston — including Early Phase 1, Phase 1, Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Boston
- NCT01353547Recruiting
Study genes and environment in multiple sclerosis risk
This study looks at how genes and life exposures may relate to developing multiple sclerosis (MS) or to MS itself. You may be invited if you have a specific connection to MS or certain past immune-related treatments.
Boston, MassachusettsAges 18 years+ - NCT06136728RecruitingPhase 3
Dalfampridine and physical therapy for walking problems in MS
This trial tests whether adding dalfampridine to physical therapy helps people with multiple sclerosis walk better. You must not already be taking dalfampridine or getting physical therapy to join.
Boston, MassachusettsAges 25–75 - NCT02649985RecruitingPhase 1/Phase 2
PET brain scan study for several brain and mood conditions
This early-phase study uses PET and MRI brain scans to better understand brain changes in multiple sclerosis, Alzheimer’s disease, and other neurological or mood conditions. The goal is to test whether these scans can show disease-related differences and guide future treatments.
Boston, MassachusettsAges 18–85 - NCT03816345RecruitingPhase 1
Nivolumab for advanced cancer with autoimmune disease
This trial tests whether the immunotherapy drug nivolumab can safely treat advanced cancer in people who also have an autoimmune disease like rheumatoid arthritis, lupus, or multiple sclerosis. It aims to find out if the drug may help control cancer while managing their autoimmune condition.
Boston, MassachusettsAges 18 years+ - NCT06433752Recruiting
Study of BRIUMVI for relapsing multiple sclerosis
This study looks at how well BRIUMVI (a medicine for relapsing multiple sclerosis) works for people in everyday life. Researchers want to see how people do when they first start the medication.
Boston, MassachusettsAges 18 years+ - NCT04699747RecruitingPhase 1
MRI and PET scan study for multiple sclerosis brain changes
This Phase 1 study tests a special tracer used during MRI and PET scans to look at brain changes in people with multiple sclerosis. It’s mainly aimed at improving how these scans can detect disease-related changes and confirming the tracer works safely.
Boston, MassachusettsAges 18–65 - NCT06890923RecruitingPhase 2
Nasal foralumab for non-active secondary progressive MS
This trial tests a nasal spray medication, foralumab, to see if it can help people with non-active secondary progressive multiple sclerosis. It is only for people who completed a previous related study (TILS-021).
Boston, MassachusettsAges 18–75 - NCT07087106RecruitingPhase 4
Glucose use in the brain of people with MS
This study uses a special PET scan to see how the brain uses sugar (glucose) in people with multiple sclerosis (MS) compared to healthy volunteers. It may help researchers understand energy changes in the brain related to MS.
Boston, MassachusettsAges 18–70 - NCT06554340Recruiting
Exercise study for multiple sclerosis with high blood pressure
This study tests if exercise can improve blood vessel health and daily function in people with multiple sclerosis (MS) who also have high blood pressure. It may help you move better and feel better.
Boston, MassachusettsAges 18 years+ - NCT07299019RecruitingPhase 3
Study of orelabrutinib for secondary progressive MS
This study tests an oral medication called orelabrutinib for people whose multiple sclerosis has changed from relapsing-remitting to secondary progressive. The goal is to see if it can slow down disability worsening that happens even without relapses.
Boston, MassachusettsAges 18–60 - NCT06735248RecruitingPhase 2
Study testing mRNA vaccine for multiple sclerosis relapse prevention
This study tests whether an mRNA vaccine (mRNA-1195) can help prevent relapses in people with early relapsing multiple sclerosis (MS). It compares the vaccine to a placebo (a shot with no active ingredient) to see if it is safe and effective.
Boston, MassachusettsAges 18–55 - NCT04603196Recruiting
Study sleep apnea in adults with multiple sclerosis
This study looks at how often sleep apnea happens in people who have multiple sclerosis, and how it affects daily life and health. You may be invited to participate if you’re an adult with a confirmed multiple sclerosis diagnosis and can consent to the study.
Boston, MassachusettsAges 18 years+ - NCT07011914Recruiting
MS care study for young adults
This study looks at how to improve care for young adults with relapsing-remitting MS. It focuses on people who are Black, Hispanic, or have limited income.
Boston, MassachusettsAges 18 years+ - NCT03207464RecruitingPhase 1/Phase 2
PET/MRI scan study for nerve inflammation in multiple sclerosis
This early-phase study uses a special PET scan and an MRI to look at nerve-related inflammation in people with multiple sclerosis (MS). The goal is to see whether this scan can detect MS-related changes, which could improve how MS is studied in the future.
Boston, MassachusettsAges 18–60 - NCT05877963RecruitingPhase 3
Ublituximab treatment plan for relapsing multiple sclerosis
This Phase 3 trial tests the safety and effectiveness of a modified treatment plan using ublituximab for relapsing multiple sclerosis. It also studies how the drug behaves in the body and aims to improve disease control while monitoring side effects.
Boston, MassachusettsAges 18–65 - NCT06846281RecruitingPhase 3
Remibrutinib for relapsing multiple sclerosis after switching from Ocrevus
This study tests a new oral medication called remibrutinib for people with relapsing multiple sclerosis who are currently on Ocrevus. Participants will switch from Ocrevus to remibrutinib to see if it is safe and effective.
Boston, MassachusettsAges 40–70 - NCT04634994RecruitingEarly Phase 1
Brain scans to measure synapses in multiple sclerosis
This early study uses special brain scans (PET and MRI) to measure “synapse density” (how many connection points brain cells have) in people with multiple sclerosis (MS). It may help researchers understand MS biology and improve future treatments.
Boston, MassachusettsAges 18–60 - NCT05957913Enrolling by invitationPhase 2
Testing antiviral drugs to control Epstein-Barr virus in MS
This Phase 2 study tests whether certain antiviral medicines can reduce Epstein-Barr virus (EBV) activity. If you have multiple sclerosis and evidence of EBV infection, the results may help clarify new ways to target EBV-related disease activity.
Boston, MassachusettsAges 18 years+ - NCT03291756Enrolling by invitation
CorEvitas Multiple Sclerosis registry for people starting MS medicine
This registry collects health information from adults with multiple sclerosis (MS) when they start an MS medicine. It may help researchers better understand treatment patterns and outcomes in real-world care.
Waltham, MassachusettsAges 18 years+ - NCT06441617Enrolling by invitation
Online program to reduce fatigue in multiple sclerosis
This trial tests an online self-management program to help reduce fatigue in people with MS. You'll use a website or app over 24 weeks, and researchers will check how well it works.
Waltham, MassachusettsAges 22 years+ - NCT02486562Recruiting
Research network for people with multiple sclerosis
This study builds a patient-powered research network for people living with multiple sclerosis. It may help by gathering real-world information from patients to improve understanding of the disease over time.
Waltham, MassachusettsAges Any age - NCT07225504RecruitingPhase 3
Study of remibrutinib for secondary progressive multiple sclerosis
This trial tests an oral medication called remibrutinib to see if it can slow disability progression in people with secondary progressive multiple sclerosis (SPMS). You might join if you have had MS for a while, your symptoms have worsened over the past year, and you haven't had any recent relapses.
Wellesley, MassachusettsAges 18–65 - NCT06681623Recruiting
Ublituximab in older adults with relapsing MS
This study is testing how safe and effective the medication ublituximab is for older adults (ages 55–80) with relapsing multiple sclerosis. It aims to see if this treatment works well for this age group.
Foxborough, MassachusettsAges 55–80 - NCT06782490RecruitingPhase 2
Testing a new drug for MS muscle stiffness
This study tests an investigational drug (BMS-986368) to see if it helps reduce muscle stiffness and spasms caused by multiple sclerosis. It may be an option if you have had spasticity for at least 6 months and are not currently using other treatments that cannot be paused.
Foxborough, MassachusettsAges 18–70
Hear when a new Multiple sclerosis trial opens near Boston, MA
We’ll email you when one opens near Boston, MA — at most once a week, no account needed, unsubscribe anytime.
Multiple sclerosis trials in other cities
Where these studies are running near Boston
Institutions with a site for the recruiting multiple sclerosis studies listed above.
- Brigham and Women's Hospital · 4 studies
- Massachusetts General Hospital · 4 studies
- Brigham MS Center, 60 Fenwood Road · 2 studies
- Neurology Center of New England P.C. · 2 studies
- TG Therapeutics Investigational Trial Site · 2 studies
- Accelerated Cure Project
- Beth Israel Deaconess Medical Center
- Boston Clinical Trials
What taking part in a multiple sclerosis study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting multiple sclerosis studies in Massachusetts.
Common questions
- Are there multiple sclerosis clinical trials near Boston?
- Yes. We're currently tracking 26 recruiting multiple sclerosis studies with a site near Boston, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a multiple sclerosis study near Boston?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Boston to take part?
- Not necessarily. These studies have a site near Boston, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a multiple sclerosis trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New multiple sclerosis studies open near Boston regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.