Clinical trials · Illinois
Multiple sclerosis clinical trials in Illinois
We’re tracking 24 recruiting multiple sclerosis studies with a site in Illinois — including Phase 1, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Illinois
- NCT07355387Recruiting
Home-based balance training for multiple sclerosis
This study tests a 12-week home-based balance training program for people with multiple sclerosis. Sessions are done online with a helper present, and the goal is to improve walking and reduce fall risk.
Chicago, IllinoisAges 40–90 - NCT07325292RecruitingPhase 3
Frexalimab injection vs IV for multiple sclerosis
This study tests if a new injection (frexalimab) works as well as the IV version for people with relapsing or certain types of secondary progressive multiple sclerosis. It could offer a more convenient way to receive this treatment at home.
Northbrook, IllinoisAges 18–60 - NCT07225361RecruitingPhase 4
Ublituximab for early relapsing multiple sclerosis
This study tests ublituximab (Briumvi), a treatment given as an infusion, for people recently diagnosed with relapsing MS. The goal is to see if starting this treatment early helps control MS better.
Chicago, IllinoisAges 18–70 - NCT05051618Recruiting
Exercise program for depression in people with multiple sclerosis
This trial studies whether a structured exercise program can help reduce symptoms of major depressive disorder in people who also have multiple sclerosis. You’ll complete questionnaires, wear an activity sensor, and do exercise testing while being assigned to the study program.
Chicago, IllinoisAges 18–64 - NCT06433752Recruiting
Study of BRIUMVI for relapsing multiple sclerosis
This study looks at how well BRIUMVI (a medicine for relapsing multiple sclerosis) works for people in everyday life. Researchers want to see how people do when they first start the medication.
Chicago, IllinoisAges 18 years+ - NCT06408259RecruitingPhase 3
Comparing ozanimod and fingolimod for children with MS
This study compares two oral medications, ozanimod and fingolimod, to see which one works better and is safer for children and teenagers with relapsing-remitting MS. Both drugs help reduce MS attacks and slow down the disease.
Chicago, IllinoisAges 10–17 - NCT06390930Recruiting
Breathing bursts of lower oxygen for hand function in MS
This study tests whether breathing short bursts of reduced oxygen (acute intermittent hypoxia) can improve hand function and nerve health in people with relapsing-remitting MS who have some hand weakness.
Chicago, IllinoisAges 18–75 - NCT06341023Recruiting
Balance training for older adults with MS
This study tests a balance training program for people with MS who have mild walking and memory difficulties. It aims to improve balance and prevent falls.
Chicago, IllinoisAges 18–90 - NCT06276634Recruiting
Low-Oxygen Therapy for People With Multiple Sclerosis
This study tests whether brief, controlled low-oxygen episodes (called intermittent hypoxia) can improve motor function in people with MS. It may help strengthen walking and daily movement.
Chicago, IllinoisAges 18–75 - NCT05124600Recruiting
Personalized MS app study for 21-day daily use
This study looks at an individualized health eLibrary app for people with multiple sclerosis (MS). You may use the app for 21 days and help researchers compare outcomes between a group using the app and a comparison group.
Champaign, IllinoisAges 18 years+ - NCT04047628RecruitingPhase 3
MS patients with active relapsing disease comparing two treatment plans
This Phase 3 study compares the best standard MS treatment (chosen by your doctors) versus an approach called autologous hematopoietic stem cell transplant (AHSCT) for people with highly active, treatment-resistant relapsing multiple sclerosis. It aims to see which option controls MS disease activity better and keeps you safer over time.
Evanston, IllinoisAges 18–55 - NCT07504120Recruiting
Home Pilates for people with multiple sclerosis
This study tests whether doing Pilates exercises from home, through online video sessions, can improve physical and mental well-being in people with mild to moderate multiple sclerosis. If you are fairly mobile and not very active, this could be a gentle way to increase exercise and feel better.
Chicago, IllinoisAges 18 years+ - NCT06846281RecruitingPhase 3
Remibrutinib for relapsing multiple sclerosis after switching from Ocrevus
This study tests a new oral medication called remibrutinib for people with relapsing multiple sclerosis who are currently on Ocrevus. Participants will switch from Ocrevus to remibrutinib to see if it is safe and effective.
Chicago, IllinoisAges 40–70 - NCT07225504RecruitingPhase 3
Study of remibrutinib for secondary progressive multiple sclerosis
This trial tests an oral medication called remibrutinib to see if it can slow disability progression in people with secondary progressive multiple sclerosis (SPMS). You might join if you have had MS for a while, your symptoms have worsened over the past year, and you haven't had any recent relapses.
Chicago, IllinoisAges 18–65 - NCT07207148Recruiting
Ocrelizumab and weight-loss drugs for MS
This study looks at combining ocrelizumab (an MS treatment) with GLP-1 agonists (like Ozempic, used for weight management) in people with MS. It aims to see if the combination is safe and beneficial.
Chicago, IllinoisAges 18–70 - NCT07167680Recruiting
Fall prevention for wheelchair users with MS or spinal cord injury
This trial tests a program to help prevent falls for people with multiple sclerosis or spinal cord injury who use a wheelchair or scooter. You will learn physical skills with a care partner to stay safe.
Urbana, IllinoisAges 18 years+ - NCT05644522Recruiting
At-home brace study for leg support and walking
This study tests an at-home wearable activity monitor and brace-related walking support for people who already use a knee-ankle-foot brace. It may help researchers understand how brace use and day-to-day movement relate to walking ability.
Chicago, IllinoisAges 18–89 - NCT07132775Recruiting
Full-body electrical stimulation suit for spasticity and pain
This study tests a full-body suit that delivers gentle electrical pulses to help reduce muscle stiffness, spasms, and pain in people with conditions like multiple sclerosis, fibromyalgia, or other neurological problems. It may help with movement and comfort.
Chicago, IllinoisAges 18–75 - NCT06450977Recruiting
MIND diet study for people with multiple sclerosis
This study tests whether the MIND diet (a combination of the Mediterranean and DASH diets) can help people with multiple sclerosis (MS). Participants will receive meals and be monitored remotely, so you can take part from home.
Urbana, IllinoisAges 18–64 - NCT06410261Recruiting
Exercise program for MS patients who use wheelchairs
This study tests an exercise program designed for people with MS who use a wheelchair but can still walk short distances with help. The goal is to see if this program improves fitness and quality of life.
Chicago, IllinoisAges 18 years+ - NCT05877963RecruitingPhase 3
Ublituximab treatment plan for relapsing multiple sclerosis
This Phase 3 trial tests the safety and effectiveness of a modified treatment plan using ublituximab for relapsing multiple sclerosis. It also studies how the drug behaves in the body and aims to improve disease control while monitoring side effects.
Chicago, IllinoisAges 18–65 - NCT07710105Recruiting
Ocrevus for MS: A Real-World Study
This study will follow people with multiple sclerosis (MS) who are starting or restarting a treatment called Ocrevus (ocrelizumab). The goal is to understand how well it works in real life over 12 months. Participants will receive Ocrevus as part of their usual care and complete surveys about their experience.
Chicago, IllinoisAges 18 years+ - NCT03816345RecruitingPhase 1
Nivolumab for advanced cancer with autoimmune disease
This trial tests whether the immunotherapy drug nivolumab can safely treat advanced cancer in people who also have an autoimmune disease like rheumatoid arthritis, lupus, or multiple sclerosis. It aims to find out if the drug may help control cancer while managing their autoimmune condition.
Chicago, IllinoisAges 18 years+ - NCT02670161Enrolling by invitationPhase 4
Using electronic records to improve care for brain and nerve conditions
This study looks at how doctors use electronic medical records to improve treatment and care for people with certain brain and nervous system conditions. It may help because it tests practice-based approaches across neurology visits.
Evanston, IllinoisAges 18–100
Multiple sclerosis trials by city in Illinois
Where these studies are running in Illinois
Institutions with a site for the recruiting multiple sclerosis studies listed above.
- Northwestern University · 6 studies
- Shirley Ryan AbilityLab · 4 studies
- University of Illinois at Chicago · 4 studies
- TG Therapeutics Investigational Trial Site · 2 studies
- University of Illinois Urbana-Champaign · 2 studies
- Consultants in Neurology- Site Number : 8400020
- Disability Participation and Quality of Life (DPQOL) Laboratory
- Local Institution - 0093
What taking part in a multiple sclerosis study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Multiple sclerosis trials in other states
Common questions
- Are there multiple sclerosis clinical trials in Illinois?
- Yes. We're currently tracking 24 recruiting multiple sclerosis studies with a site in Illinois, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a multiple sclerosis study in Illinois?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Illinois to take part?
- Not necessarily. These studies have a site in Illinois, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a multiple sclerosis trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New multiple sclerosis studies open in Illinois regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.