Clinical trials
Multiple sclerosis clinical trials
A condition in which the immune system attacks the protective covering of nerves. We’re tracking 443 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05809986Recruiting
Study of ofatumumab in adults with relapsing multiple sclerosis
This is an observational study (no random treatment) that follows adults with relapsing multiple sclerosis (RMS) who are taking ofatumumab. The study aims to better understand how patients do in real-world care while completing questionnaires and other scheduled check-ins.
AmadoraAges 18–99 - NCT06486779Recruiting
Study of Kesimpta in Greek MS Patients
This study watches how well Kesimpta (ofatumumab) works for people with relapsing multiple sclerosis over time. It collects information from routine doctor visits and scans to see if the treatment is controlling the disease.
Athens, AtticaAges 18–55 - NCT06796504Recruiting
Nerve stimulation for relapsing-remitting multiple sclerosis
This trial tests a device that stimulates a nerve in the neck, which may help repair the protective coating around nerves in the brain and spinal cord. It is for people with relapsing-remitting MS who are stable on their current medication and have some vision problems due to MS.
Irvine, CaliforniaAges 22–60 - NCT02994121Recruiting
Study of multiple sclerosis in the Three Rivers region
This study follows people with multiple sclerosis (MS) and some healthy people in the local area to better understand MS and related nerve conditions. It may help researchers learn which symptoms and scan changes show up over time.
Pittsburgh, PennsylvaniaAges 7 years+ - NCT06865274Recruiting
A look at gene changes in MS, NMOSD, and MOGAD
This study looks at a specific gene change in people with MS, NMOSD, or MOGAD to see how common it is. By joining, you help researchers learn more about these conditions and possible future treatments.
Roma, RomaAges 18 years+ - NCT06890923RecruitingPhase 2
Nasal foralumab for non-active secondary progressive MS
This trial tests a nasal spray medication, foralumab, to see if it can help people with non-active secondary progressive multiple sclerosis. It is only for people who completed a previous related study (TILS-021).
Boston, MassachusettsAges 18–75 - NCT06956326RecruitingPhase 2
Early rehab for multiple sclerosis relapse recovery
This trial tests whether early and specialized rehabilitation can help people with multiple sclerosis recover better after a motor relapse. It is for people who are already staying at a Danish MS Hospital for rehab.
HaslevAges 18 years+ - NCT07304375Recruiting
Exercise and sleep effects on learning and abilities in MS
This trial tests how combining exercise and sleep monitoring can improve motor learning and daily function in people with early relapsing-remitting multiple sclerosis. It may help you move better and feel more capable in daily life.
CopenhagenAges 18–70 - NCT05754593Recruiting
Study ovarian reserve in women with multiple sclerosis
This study compares egg supply (“ovarian reserve”) in women with multiple sclerosis to women without MS. It may help doctors understand how MS affects reproductive health and egg supply.
BordeauxAges 25–35 - NCT06955832Recruiting
Early MS Brain Lesion Detection Using Advanced MRI
This study tests a special type of MRI called Phase Sensitive Inversion Recovery to find brain lesions (areas of damage) in people with multiple sclerosis. The goal is to catch these lesions earlier to help guide treatment.
Banhā, Qalyubia GovernorateAges 15–65 - NCT07292480Recruiting
Monthly NfL monitoring for relapsing-remitting MS
This trial tests whether monthly blood tests for a nerve protein (NfL) can detect hidden disease activity in people with relapsing-remitting multiple sclerosis (RRMS) who are on certain first-line treatments. It aims to find out if this monitoring helps catch early signs of active disease before symptoms appear.
NiceAges 18–55 - NCT07183020Enrolling by invitation
Kappa Free Light Chains in MS and CIS
This study looks at a protein called kappa free light chains (KFLC) in the spinal fluid and blood of people with multiple sclerosis (MS) or a first MS-like episode (CIS). The goal is to better understand how this protein relates to the disease, which may help with diagnosis and monitoring.
Hanover, Lower SaxonyAges 18–70 - NCT07555015Recruiting
Online Support Group for Women With Multiple Sclerosis
This study tests an online program led by nurses that helps women with multiple sclerosis find meaning and purpose in their lives. The program uses group discussions to improve quality of life and emotional well-being.
Denton, TexasAges 18 years+ - NCT04707976Recruiting
Smart anal irrigation vs standard care for bowel issues in MS
This study compares a smart device for transanal irrigation with regular bowel care in people with multiple sclerosis (MS) who have ongoing bowel problems. It aims to see if the smart irrigation approach improves bowel control and reduces symptoms.
AarhusAges 18 years+ - NCT05849467RecruitingPhase 1
Testing how the brain absorbs anti–CD8 therapy in nervous system disease
This Phase 1 study tests a small drug (called an anti–CD8+ T cell minibody) to see how much reaches the brain. It may help researchers understand how to deliver similar treatments for multiple sclerosis, progressive multifocal leukoencephalopathy (PML), or other brain inflammation when the brain’s protective barrier is “open.”
Bethesda, MarylandAges 18–120 - NCT06715436Recruiting
Ketogenic diet for multiple sclerosis
This study tests whether a ketogenic diet can help people with multiple sclerosis. You would follow a special high-fat, low-carb diet for a period, and the researchers will check its effects on your symptoms and overall health.
PaviaAges 18–60 - NCT06795230Recruiting
Arm exercise with blood flow cuffs for MS
This study tests a type of arm exercise that uses a blood pressure cuff to limit blood flow, aiming to improve arm function in people with multiple sclerosis. It may help if you have some arm weakness but no recent relapses or blood clotting issues.
Leganés, MadridAges 18 years+ - NCT07058896Recruiting
Improving walking skills in progressive multiple sclerosis
This study tests a program to help people with progressive multiple sclerosis who have severe walking difficulty. It aims to see if the program is feasible and can improve motor skills.
Ferrara, FEAges 18–75 - NCT07207148Recruiting
Ocrelizumab and weight-loss drugs for MS
This study looks at combining ocrelizumab (an MS treatment) with GLP-1 agonists (like Ozempic, used for weight management) in people with MS. It aims to see if the combination is safe and beneficial.
Chicago, IllinoisAges 18–70 - NCT05958381Recruiting
Brain stimulation for memory problems in relapsing MS
This trial studies a noninvasive brain stimulation treatment to improve memory (specifically memory recall) in people with relapsing-remitting multiple sclerosis (RRMS). It may help if your memory testing shows a “retrieval” problem, and if you’re able to follow the study treatment and safety requirements.
Richardson, TexasAges 18–65 - NCT07609719RecruitingPhase 4
Switch to under-the-skin ocrelizumab for multiple sclerosis
This trial tests a new way of taking Ocrelizumab as a shot under the skin, for people with MS who are already on a similar treatment and want to switch. The goal is to see if switching is safe and works well.
GuaynaboAges 18–65 - NCT06640660Recruiting
Study of vision, thinking, and emotions in MS and West Nile
This study looks at how multiple sclerosis or West Nile virus affects visual thinking and mood, and whether a rehab program might help. If you have one of these conditions and can see and use your hands, you may be able to join.
Lido, VeneziaAges 20–85 - NCT06675955RecruitingPhase 3
Extension study to keep taking ocrelizumab for multiple sclerosis
This extension study continues treatment with ocrelizumab for people with multiple sclerosis who are already taking it as part of a parent trial, to see how MS affects physical function over a longer time. It helps ensure you can keep receiving ocrelizumab even if it's not available where you live.
Amiens Cedex1Ages 18 years+ - NCT07058870Recruiting
Improving walking skills in progressive multiple sclerosis
This study is testing a new way to help people with progressive multiple sclerosis improve their walking and motor skills. If you have mild to moderate trouble walking and meet some other health criteria, you may be able to join.
Ferrara, FEAges 18–75
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Common questions
- Are there clinical trials for multiple sclerosis?
- Yes. Clin2 currently lists 443 recruiting multiple sclerosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a multiple sclerosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a multiple sclerosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Multiple Sclerosis, Relapsing-Remitting
- Multiple Sclerosis (MS) - Relapsing-remitting
- Multiple Sclerosis, Secondary Progressive
- Relapsing Multiple Sclerosis
- Multiple Sclerosis, Primary Progressive
- Progressive Multiple Sclerosis
- Multiple Sclerosis (MS) Primary Progressive
- Multiple Sclerosis (MS) Secondary Progressive
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.