Clinical trials · North Carolina
Narcolepsy clinical trials in North Carolina
We’re tracking 13 recruiting narcolepsy studies with a site in North Carolina — including Phase 2, Phase 2/Phase 3 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT06767683RecruitingPhase 2/Phase 3
Long-term study of ALKS 2680 for narcolepsy and idiopathic hypersomnia
This study is for people with narcolepsy or idiopathic hypersomnia who have already taken part in an earlier ALKS 2680 study. It aims to see how well the medication works and how safe it is when taken for a longer time.
Denver, North CarolinaAges 18–70 - NCT07363720RecruitingPhase 3
A study of TAK-861 for narcolepsy with cataplexy
This trial tests a new medication called TAK-861 for people with narcolepsy type 1 (NT1), which causes sudden muscle weakness (cataplexy) and extreme daytime sleepiness. The study aims to see if TAK-861 can help reduce these symptoms.
Durham, North CarolinaAges 16–70 - NCT06752668RecruitingPhase 2
Testing ORX750 for narcolepsy and idiopathic hypersomnia
This trial tests an experimental drug called ORX750 for people with narcolepsy or idiopathic hypersomnia. You would need to stop your current sleepiness medicines to see if ORX750 helps reduce daytime sleepiness.
Huntersville, North CarolinaAges 18–65 - NCT07096674RecruitingPhase 2
Long-term study of ORX750 for narcolepsy and idiopathic hypersomnia
This trial is for people who have already completed the main CRYSTAL-1 study of ORX750. It tests the long-term safety and effects of the drug, so you can continue treatment if it was helping you.
Huntersville, North CarolinaAges 18–65 - NCT07598708RecruitingPhase 2/Phase 3
Cleminorexton for Narcolepsy: A New Treatment Study
This study tests whether a new medication called cleminorexton helps people with narcolepsy (a condition causing severe daytime sleepiness) sleep better and feel more alert. You would take this medication instead of your current narcolepsy drugs for several months to see if it works.
Denver, North CarolinaAges 18–70 - NCT07502443RecruitingPhase 3
Study of ALKS 2680 for narcolepsy type 2
This study tests an investigational drug called ALKS 2680 for people with narcolepsy type 2, a condition that causes excessive daytime sleepiness without sudden muscle weakness. The goal is to see if the drug is safe and helps reduce daytime sleepiness.
Charlotte, North CarolinaAges 18–70 - NCT07455383RecruitingPhase 3
Testing ALKS 2680 for adults with narcolepsy type 1
This study tests a new medication, ALKS 2680, to see if it helps reduce daytime sleepiness and other symptoms in adults with narcolepsy type 1. It may offer a new treatment option for people with this condition.
Charlotte, North CarolinaAges 18–70 - NCT07540897RecruitingPhase 3
Testing ALKS 2680 for narcolepsy type 1
This study tests whether a new medication called ALKS 2680 can help people with narcolepsy type 1 stay more awake and alert during the day. Narcolepsy type 1 is a neurological condition where people fall asleep unexpectedly and may experience sudden muscle weakness.
Charlotte, North CarolinaAges 18–70 - NCT06952699RecruitingPhase 2
TAK-360 for narcolepsy type 2
This study tests a new medicine called TAK-360 for people with narcolepsy type 2 (narcolepsy without cataplexy). It aims to see if the drug safely reduces daytime sleepiness.
Denver, North CarolinaAges 18–70 - NCT07493265RecruitingPhase 2
Study of E2086 for adults with narcolepsy
This study tests a new drug called E2086 to see if it can help reduce daytime sleepiness and sudden muscle weakness in adults with narcolepsy. It involves two groups: people with cataplexy (type 1) and those without (type 2).
Denver, North CarolinaAges 18 years+ - NCT05816382RecruitingPhase 2/Phase 3
Testing TAK-861 for narcolepsy type 1 sleepiness
This Phase 2/3 study tests TAK-861 in people with narcolepsy type 1 (NT1) who already completed an earlier TAK-861 trial. The goal is to see if the medicine remains safe and effective for ongoing central (brain-related) sleepiness problems.
Denver, North CarolinaAges 16–70 - NCT05536011Recruiting
Pregnancy registry for women taking WAKIX (pitolisant)
This registry collects information about pregnancy outcomes in women who took WAKIX (pitolisant) or a similar comparison medicine during pregnancy. It helps doctors understand the safety and effects of these medicines in pregnancy.
Morrisville, North CarolinaAges Any age - NCT06413420Recruiting
Study of Solriamfetol Use During Pregnancy
This registry study tracks the safety of Sunosi (solriamfetol) and other wakefulness medications taken during pregnancy. It aims to gather information to help doctors and pregnant women make informed treatment decisions.
Morrisville, North CarolinaAges Any age
Where these studies are running in North Carolina
Institutions with a site for the recruiting narcolepsy studies listed above.
- Alkermes Investigational Site · 4 studies
- Denver, North Carolina · 3 studies
- Huntersville, North Carolina · 3 studies
- Evidera, a PPD business unit · 2 studies
- Research Carolina Elite · 2 studies
- Takeda · 2 studies
- ARSM Research, LLC
- PPD
What taking part in a narcolepsy study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Narcolepsy trials in other states
Common questions
- Are there narcolepsy clinical trials in North Carolina?
- Yes. We're currently tracking 13 recruiting narcolepsy studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a narcolepsy study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a narcolepsy trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New narcolepsy studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.