Clinical trials
Nicotine Use Disorder clinical trials
Below are recruiting nicotine use disorder clinical trials, each written for real people, not researchers. We’re tracking 154 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07118618RecruitingPhase 2
Probenecid for alcohol cravings and drinking
This study tests if the medication probenecid can help reduce cravings for alcohol and the amount you drink. It is for people who drink heavily and have moderate to severe alcohol use disorder.
Providence, Rhode IslandAges 18 years+ - NCT07050862Recruiting
Personalized brain stimulation to help veterans quit smoking
This study tests a personalized brain stimulation treatment to help veterans quit smoking. It uses magnetic pulses to target brain areas involved in addiction, which may reduce cravings and make it easier to stop.
Charleston, South CarolinaAges 18–70 - NCT07028983Recruiting
Music therapy for drug and alcohol addiction recovery
This trial tests if adding music therapy to standard addiction treatment helps people recover from substance use disorders. It is for adults who have completed detox and are not currently going through detox.
ViennaAges 18 years+ - NCT06899594RecruitingEarly Phase 1
Psilocybin for quitting methamphetamine
This trial tests whether psilocybin (a psychedelic medicine) can help people quit methamphetamine. You'll receive counseling before, during, and after the drug session, and your progress will be followed for several months.
Shreveport, LouisianaAges 25–65 - NCT06810310RecruitingPhase 2
Psilocybin for motivation in opioid use disorder
This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can help people with opioid use disorder stay motivated in recovery. It uses brain scans to see how psilocybin affects brain areas linked to motivation.
Philadelphia, PennsylvaniaAges 18–60 - NCT06786325RecruitingPhase 2
Psilocybin treatment study for opioid use disorder
This trial tests whether psilocybin can help people recovering from opioid use disorder while living at a residential treatment center. If you are already taking buprenorphine/naloxone (Suboxone), methadone, or have received Sublocade, this study may be an option for you.
Philadelphia, PennsylvaniaAges 18–60 - NCT06784908Recruiting
Stress and pain study for people living with HIV
This study looks at how stress affects pain in people with HIV. It may help find better ways to manage pain in this group.
New Haven, ConnecticutAges 18–68 - NCT06575751RecruitingPhase 2
Study of cannabidiol and cannabis concentrate users
This study looks at how cannabidiol (a compound in cannabis) affects people who regularly use strong cannabis concentrates like wax, shatter, or oil. It may help understand if using CBD can change how cannabis affects the body or help with cannabis use disorder.
Aurora, ColoradoAges 25–60 - NCT06569394RecruitingPhase 2
Testing CBD in young adults who use cannabis heavily
This study tests whether cannabidiol (CBD) can help young adults who use cannabis heavily but aren't looking to quit. You'll take a CBD pill and see if it changes your cannabis use or related symptoms.
Aurora, ColoradoAges 18–25 - NCT06494891RecruitingPhase 2
Understanding motivation for IV alcohol drinking
This study looks at why people with alcohol use disorder choose to drink alcohol given through an IV. The goal is to better understand the motivation behind drinking, which could help improve treatments.
Los Angeles, CaliforniaAges 21–65 - NCT06349083RecruitingPhase 2
Psilocybin-assisted treatment for alcohol use disorder
This study tests whether psilocybin, a psychedelic drug, combined with therapy can help people reduce or stop drinking. It aims to understand how psilocybin affects the brain and behavior in people with alcohol use disorder.
New York, New YorkAges 18–65 - NCT05178069RecruitingPhase 2
Probiotic supplement study for alcohol use disorder and liver injury
This Phase 2 trial studies whether a probiotic (LGG) can improve health in people with alcohol use disorder and alcohol-related liver injury. It’s not an alcohol treatment study, so participants are mainly joining to see how the supplement affects the body and liver-related outcomes.
Louisville, KentuckyAges 21–65 - NCT05929677RecruitingEarly Phase 1
Study tests effects on impulsivity and how alcohol feels
This early-phase study looks at how alcohol affects impulsivity (tendency to act quickly) and people’s subjective experiences. You may be able to join if you drink regularly and meet the study safety rules.
Boston, MassachusettsAges 21–25 - NCT05703685RecruitingPhase 1
Imaging brain inflammation target in depression with PET
This Phase 1 study uses a PET brain scan tracer to see how a specific brain target (PDE4B) is involved in major depressive disorder (MDD). It’s mainly testing whether the imaging approach works and what it shows in people with depression who meet specific safety and medication rules.
Bethesda, MarylandAges 18–70 - NCT05062369Recruiting
Brain stimulation plus training to support alcohol abstinence
This study tests whether a combination of brain stimulation (tDCS) and cognitive training can help people with alcohol use disorder stay abstinent. You may be included if you are currently not drinking and can commit to the program timeline.
Minneapolis, MinnesotaAges 18–65 - NCT05008146RecruitingEarly Phase 1
Brain imaging study for cocaine use disorder interactions
This early-phase study uses brain imaging to understand how cocaine use disorder affects brain function. It may help researchers learn more about brain pathways involved in craving and treatment targets.
Pittsburgh, PennsylvaniaAges 18–55 - NCT05028062RecruitingPhase 4
Naltrexone injections for people who want to cut alcohol drinking
This Phase 4 study tests whether naltrexone injections can help people with alcohol use disorder (AUD) reduce or stop heavy drinking. You may get two injections over 8 weeks, and you can join if you meet specific drinking pattern and eligibility rules.
Philadelphia, PennsylvaniaAges 18–65 - NCT06043362Recruiting
Nicotine pouches for daily smokers
This study tests if nicotine pouches can help daily smokers reduce how many cigarettes they smoke. You'll try nicotine pouches, and researchers will track your progress.
Hershey, PennsylvaniaAges 21–70 - NCT06381180RecruitingPhase 1/Phase 2
Cannabis for Veterans with PTSD
This study is testing whether cannabis can help veterans with PTSD feel better. It is for veterans who have used cannabis before and currently have PTSD symptoms.
Detroit, MichiganAges 19–69 - NCT03540758RecruitingPhase 2
Study of how brain sugar control channels affect blood sugar
This Phase 2 study tests how certain channels in the brain help control how your body makes and releases sugar (glucose). It may help explain blood sugar problems in people with type 2 diabetes and healthy volunteers.
The Bronx, New YorkAges 21–70 - NCT07712887Recruiting
Studying how IQOS users puff across device models
This study looks at how people who regularly use IQOS inhale from different versions of the device. It aims to understand how the feeling and pattern of use change between models.
Beirut, BeirutAges 18–65 - NCT04935619Recruiting
Testing cannabis abstinence effects in depression symptoms
This study looks at how stopping cannabis for a period of time may affect depression symptoms and thinking/memory. You might benefit by getting close monitoring of mood and cognition while researchers compare changes during cannabis abstinence.
Toronto, OntarioAges 18–55 - NCT06747871Recruiting
Opioids, low nicotine cigarettes, and chronic pain study
This study tests if using cigarettes with very low nicotine can help people with chronic pain who are on buprenorphine for opioid use disorder. It aims to see if this approach reduces smoking and helps you think about quitting.
Durham, North CarolinaAges 21 years+ - NCT07764536Recruiting
Parent training plus a digital tool for child temper outbursts
This trial tests whether a digital tool can make parent training more effective for children who have frequent temper outbursts and irritability. The training helps parents learn skills to manage their child's behavior, and the digital tool may help them practice and apply those skills.
Bethesda, MarylandAges 8–13
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Common questions
- Are there clinical trials for nicotine use disorder?
- Yes. Clin2 currently lists 154 recruiting nicotine use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a nicotine use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a nicotine use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.