Clinical trials
Nicotine Use Disorder clinical trials
Below are recruiting nicotine use disorder clinical trials, each written for real people, not researchers. We’re tracking 156 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05786157Recruiting
Couples alcohol and safety support for drinking and relationship harm
This study tests a patient-focused approach to help couples where alcohol misuse and relationship physical harm may be happening. You may be asked to take part in sessions focused on safety, coping, and relationship communication, and some components may include controlled alcohol exposure.
Charleston, South CarolinaAges 21 years+ - NCT05885542RecruitingPhase 1/Phase 2
Testing CBD pills for cannabis use and stress in young adults
This early-phase study tests whether a CBD pill (compared with a placebo sugar pill) can affect cannabis use and stress in people ages 18–25 who use cannabis very frequently. It may help your stress levels and cannabis-related symptoms while researchers carefully monitor safety and abstinence periods during visits.
Charleston, South CarolinaAges 18–25 - NCT06207162Recruiting
Brain scans and methadone treatment for opioid recovery
This study uses MRI scans over time to track brain changes in people with opioid use disorder who recently started methadone treatment. You can help researchers understand recovery patterns if you are early in your methadone journey and can commit to repeated visits.
New Haven, ConnecticutAges 18–50 - NCT05886582RecruitingPhase 2
Rotigotine patch added to therapy for cocaine use
This Phase 2 study tests whether a rotigotine skin patch, used alongside behavioral therapy, can help people reduce cocaine use. It also looks at changes in brain activity while you do study tasks.
Richmond, VirginiaAges 25–70 - NCT03745339Recruiting
Smell-based memory task in people with opioid-use disorder
This study tests how people learn and infer what something means using a smell-and-memory task. It compares people with opioid-use disorder who are abstinent, those in maintenance treatment, and healthy controls to see what affects learning and decision-making after opioid use.
Baltimore, MarylandAges 21–60 - NCT06636227RecruitingPhase 1
Diclofenac dose study for alcohol use disorder
This study tests whether different doses of diclofenac, an anti-inflammatory drug, can help people reduce heavy drinking. It looks at how the drug affects drinking patterns and overall health.
Catonsville, MarylandAges 21–65 - NCT06066996RecruitingEarly Phase 1
Study of withdrawal symptoms when people vape less
This study looks at what happens when people who vape nicotine daily try to cut back. Researchers want to understand withdrawal symptoms and find better ways to help people reduce or quit vaping.
Baltimore, MarylandAges 21–55 - NCT05365347Recruiting
Program to reduce risky alcohol use in early psychosis
This study tests an intervention aimed at helping people with early psychosis who also drink in a risky way. It may help reduce problematic drinking during a critical early period of illness.
Halifax, Nova ScotiaAges 16–35 - NCT06474299RecruitingPhase 4
Quit Smoking and Vaping With Patches and Pills
This study tests whether a combination of a nicotine patch plus a medication called varenicline can help people who both smoke and vape quit both. You'll get free medication and support to help you stop.
Madison, WisconsinAges 21 years+ - NCT05453513Recruiting
Study how depression and cannabis affect the brain in young adults with HIV
This study looks at brain activity to understand how depression and cannabis use may be linked in young adults living with HIV. It mainly involves questionnaires, mental health screening, and brain scans, which may help researchers better understand risk factors and brain “underpinnings.”
Miami, FloridaAges 18–59 - NCT04871048Recruiting
tDCS training to reduce cannabis use in people with schizophrenia
This trial tests whether a non-painful brain stimulation method (tDCS) can help people with schizophrenia who also have moderate-to-severe cannabis use disorder reduce or quit cannabis. It also involves MRI scanning to help study brain changes.
BronAges 18–60 - NCT05999383RecruitingPhase 2
Marijuana and tobacco use study
This trial looks at how marijuana and tobacco work together in your body. If you regularly use both cannabis and tobacco, you may help researchers understand their combined effects.
San Francisco, CaliforniaAges 21–65 - NCT04971954Recruiting
Nicotine test to improve age-related hearing processing
This study tests whether nicotine can improve how your brain processes sounds, which can get worse with age. It’s designed for non-smokers without significant hearing or medical/medication issues.
Irvine, CaliforniaAges 18–85 - NCT05723588RecruitingPhase 2
TMS brain stimulation to help veterans quit smoking with PTSD
This Phase 2 study tests whether targeted brain stimulation (TMS) can improve smoking quit outcomes in Veterans who also have PTSD. It also uses brain imaging (MRI) to understand what changes in the brain may help people quit.
Durham, North CarolinaAges 18–75 - NCT06349083RecruitingPhase 2
Psilocybin-assisted treatment for alcohol use disorder
This study tests whether psilocybin, a psychedelic drug, combined with therapy can help people reduce or stop drinking. It aims to understand how psilocybin affects the brain and behavior in people with alcohol use disorder.
New York, New YorkAges 18–65 - NCT07457489Recruiting
Brain stimulation for opioid recovery
This study tests a non-invasive brain stimulation technique called TMS to see if it can reduce opioid cravings and help people who are already taking buprenorphine stay in recovery. TMS uses magnetic pulses to stimulate parts of the brain involved in addiction.
Brentwood, TennesseeAges 18–65 - NCT06569394RecruitingPhase 2
Testing CBD in young adults who use cannabis heavily
This study tests whether cannabidiol (CBD) can help young adults who use cannabis heavily but aren't looking to quit. You'll take a CBD pill and see if it changes your cannabis use or related symptoms.
Aurora, ColoradoAges 18–25 - NCT04793685RecruitingPhase 2
Prazosin for alcohol withdrawal symptoms in alcohol use disorder
This study tests whether prazosin can reduce symptoms that happen when someone stops or cuts back on heavy drinking. It may help people with moderate-to-severe alcohol use disorder who also have alcohol withdrawal symptoms.
New Haven, ConnecticutAges 18–70 - NCT05008146RecruitingEarly Phase 1
Brain imaging study for cocaine use disorder interactions
This early-phase study uses brain imaging to understand how cocaine use disorder affects brain function. It may help researchers learn more about brain pathways involved in craving and treatment targets.
Pittsburgh, PennsylvaniaAges 18–55 - NCT05703685RecruitingPhase 1
Imaging brain inflammation target in depression with PET
This Phase 1 study uses a PET brain scan tracer to see how a specific brain target (PDE4B) is involved in major depressive disorder (MDD). It’s mainly testing whether the imaging approach works and what it shows in people with depression who meet specific safety and medication rules.
Bethesda, MarylandAges 18–70 - NCT07644052RecruitingPhase 3
A medication to ease cannabis withdrawal symptoms
This study tests whether a medication called PP-01 can help reduce cravings and uncomfortable symptoms when people stop using cannabis. If you're a heavy cannabis user who wants to quit and experiences withdrawal symptoms, this trial may help you manage the difficult transition.
Little Rock, ArkansasAges 18–55 - NCT06575751RecruitingPhase 2
Study of cannabidiol and cannabis concentrate users
This study looks at how cannabidiol (a compound in cannabis) affects people who regularly use strong cannabis concentrates like wax, shatter, or oil. It may help understand if using CBD can change how cannabis affects the body or help with cannabis use disorder.
Aurora, ColoradoAges 25–60 - NCT07050862Recruiting
Personalized brain stimulation to help veterans quit smoking
This study tests a personalized brain stimulation treatment to help veterans quit smoking. It uses magnetic pulses to target brain areas involved in addiction, which may reduce cravings and make it easier to stop.
Charleston, South CarolinaAges 18–70 - NCT07602270Recruiting
How a Ketogenic Diet Affects Alcohol in Your Body
This study tests whether eating a ketogenic diet (very low carb, high fat) changes how your body processes alcohol. Researchers will have you follow a special diet and then measure your body's response to controlled amounts of alcohol in a lab setting.
Philadelphia, PennsylvaniaAges 21–50
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Common questions
- Are there clinical trials for nicotine use disorder?
- Yes. Clin2 currently lists 156 recruiting nicotine use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a nicotine use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a nicotine use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.