Clinical trials
OA clinical trials
Below are recruiting oa clinical trials, each written for real people, not researchers. We’re tracking 91 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06884865RecruitingPhase 2
Study of an experimental knee injection for osteoarthritis pain
This study tests a new investigational medicine injected into the knee to see if it is safe and tolerable for people with painful knee osteoarthritis. It may help reduce pain and improve knee function.
Birmingham, AlabamaAges 45–80 - NCT06885372Enrolling by invitation
Long-term follow-up of ACL tear patients without surgery
This trial is for people with a torn ACL who are young (up to 25) and have certain risk factors for knee instability. It will follow them long-term to see how their knee does without surgery, focusing on those who are active in pivoting sports, have a loose knee joint, or have naturally loose joints.
Banff, AlbertaAges 14–25 - NCT06872567Recruiting
Knee artery block vs. steroid injection for arthritis pain
This study compares two treatments for knee arthritis pain: a procedure that blocks blood flow to the painful area (genicular artery embolization) versus a steroid injection into the knee joint. The goal is to see which one provides better pain relief.
Charlottesville, VirginiaAges 40 years+ - NCT06845553RecruitingPhase 2
Vutiglabridin for knee osteoarthritis: a phase 2 study
This trial tests an experimental pill called Vutiglabridin for people with knee osteoarthritis. It aims to see if the drug is safe and effective at reducing knee pain and improving function.
Seongnam-si, Gyeonggi-doAges 40–75 - NCT06809998RecruitingPhase 1/Phase 2
Steroid injection in non-surgical knee before knee replacement
This study tests whether a single steroid injection in the healthy knee (the one not being replaced) can reduce pain and improve recovery after total knee replacement. It may help people who have arthritis in both knees but are only having one replaced now.
Toronto, OntarioAges 18 years+ - NCT06617975Recruiting
Spa therapy for knee arthritis
This trial tests whether spa therapy (balneotherapy) can help people with knee osteoarthritis. You would receive treatment at the Santenay spa as part of your regular care.
Santenay, BurgundyAges 50–80 - NCT06702046Recruiting
Pulsed radiofrequency acupuncture for knee osteoarthritis
This trial tests whether a special type of acupuncture using mild radiofrequency energy can reduce knee pain and improve function in people with knee osteoarthritis. It involves 4 weeks of treatment and a 3-month follow-up to see if the benefits last.
Taipei, StateAges 45–85 - NCT06670651Enrolling by invitation
Study of a new total knee replacement system
This trial is testing a new knee replacement system called LinkSymphoKnee. It is for people needing a first-time total knee replacement to help reduce pain and improve function.
Birmingham, AlabamaAges 18–79 - NCT06681142Recruiting
Pharmacist-physiotherapist team care for early knee osteoarthritis
This study tests a new way to manage early knee osteoarthritis by having a pharmacist and physiotherapist work together. You might get help with pain, stiffness, and movement without needing surgery or strong medications.
Sherwood Park, AlbertaAges 50 years+ - NCT06596824Recruiting
Digital training to reduce inflammation after ACL knee surgery
This trial tests a personalized digital training program for people who recently had ACL knee surgery. The goal is to see if correcting movement patterns can lower inflammation and prevent early knee arthritis.
BerlinAges 18–50 - NCT06281184Enrolling by invitation
Long-term follow-up of methotrexate for hand osteoarthritis
This study follows up on people who took part in the MERINO trial to see if methotrexate has lasting benefits for hand osteoarthritis. It aims to understand how the drug affects pain and joint health over 30 months.
OsloAges 18 years+ - NCT06187038Recruiting
Pain education study for knee osteoarthritis
This trial tests if learning about chronic pain can help people with knee osteoarthritis feel better. You'll join a program that teaches you about pain and how to manage it.
São PauloAges 40–80 - NCT06084364RecruitingPhase 4
Steroid vs saline injection vs occupational therapy for thumb arthritis
This study compares a steroid injection (Kenacort), a saltwater (saline) injection, and occupational therapy to see which works best for thumb base osteoarthritis pain. It may help you if you have thumb pain with swelling and want to avoid surgery.
BodøAges 40–85 - NCT05839535RecruitingPhase 2
Baduanjin plus brain stimulation for knee osteoarthritis pain
This Phase 2 study tests whether combining Baduanjin (a guided mind-body movement) with neuromodulation can improve knee osteoarthritis symptoms and function. It compares education-based stretching/control and uses MRI scanning as part of the research.
Charlestown, MassachusettsAges 45–75 - NCT03383081RecruitingPhase 2
Stem cell injection for moderate knee osteoarthritis pain
This Phase 2 study tests whether injected umbilical-cord stem cells can improve safety and reduce symptoms in people with moderate knee osteoarthritis. It focuses on people with significant knee pain who have not gotten enough relief from standard, non-procedure treatments.
Changsha, HunanAges Up to 70 years - NCT05517434RecruitingPhase 2/Phase 3
Autologous bone and fat injections versus saline for knee OA
This trial compares different knee injections made from your own bone marrow and/or fat, plus platelet-rich plasma (a blood-derived healing factor), against saline (placebo) to treat painful knee osteoarthritis. It aims to see whether these “autologous” injections reduce knee pain and improve function.
Toronto, OntarioAges 30 years+ - NCT05495334Recruiting
Add knee osteoarthritis outcomes to a patient registry
This study tests a new way to collect how people with knee osteoarthritis feel and function after usual care (like injections, nerve-blocking procedures, or knee replacement). It may help improve future treatment decisions by using your regular follow-up reports in an app or online.
Phoenix, ArizonaAges Any age - NCT04651673Enrolling by invitation
Knee brace program for adults with knee osteoarthritis pain
This trial looks at using a prescribed knee brace to help relieve knee pain and symptoms from knee osteoarthritis. You may be able to join if your knee braces are being provided through participating clinics and you can consent and complete study questionnaires.
Hässleholm, Skåne CountyAges 18–100 - NCT03734900RecruitingPhase 4
Comparing two knee injection treatments for osteoarthritis
This study compares two knee injection treatments for knee osteoarthritis. It aims to see which one works better for reducing pain and improving function, so you might experience less knee pain and better mobility.
TaipeiAges 50–80
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Common questions
- Are there clinical trials for oa?
- Yes. Clin2 currently lists 91 recruiting oa studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a oa trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a oa trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.