Clinical trials
Opioid Use Disorder, Moderate clinical trials
Below are recruiting opioid use disorder, moderate clinical trials, each written for real people, not researchers. We’re tracking 87 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06160284RecruitingPhase 1
Psilocybin for brain healing in opioid recovery
This study tests whether psilocybin, a psychedelic substance, can help change brain connections in people recovering from opioid use disorder. It involves brain scans and careful medical monitoring to explore new treatment options.
New Haven, ConnecticutAges 25–55 - NCT06067737RecruitingPhase 2
Psilocybin and buprenorphine for opioid use disorder
This study tests whether adding psilocybin (a psychedelic medicine) to buprenorphine (a medication for opioid use disorder) can help people stop using opioids and stay in recovery. It is for people who have already been on buprenorphine but are still using other opioids.
Baltimore, MarylandAges 21–70 - NCT05834478RecruitingPhase 3
Noninvasive vagus nerve stimulation for opioid use disorder
This trial tests whether noninvasive vagus nerve stimulation can help people with opioid use disorder during supervised withdrawal and treatment afterward. It may be considered if you can safely move to medication or behavioral care after withdrawal.
Atlanta, GeorgiaAges 18–75 - NCT05829655RecruitingEarly Phase 1
Measuring drug cravings in people with opioid use disorder
This study tests whether the medication suvorexant can reduce drug cravings in people with opioid use disorder. You will take either suvorexant or a placebo and have your cravings measured in a safe setting.
Baltimore, MarylandAges 18–65 - NCT05511909RecruitingPhase 2
Buspirone study for opioid withdrawal symptoms
This Phase 2 study tests whether buspirone can help reduce symptoms during opioid detox (withdrawal). You may be able to take part if you have opioid withdrawal and are planning medically supervised detox.
Baltimore, MarylandAges 18–75 - NCT05529927RecruitingPhase 2
Dexamphetamine given long-acting to reduce cocaine use
This Phase 2 study tests whether a long-acting form of dexamphetamine can reduce cocaine use in people with moderate to severe cocaine use disorder. It also checks safety, including heart and mental health side effects, while you attend study visits regularly.
The HagueAges 18 years+ - NCT05219175RecruitingPhase 2
MDMA therapy for PTSD and opioid addiction after childbirth
This Phase 2 study tests whether MDMA-assisted therapy can reduce symptoms of PTSD and help with opioid use disorder in people after childbirth. You must be on a stable, low enough dose of methadone or buprenorphine and be able to follow study rules, including therapy sessions and safety monitoring.
Albuquerque, New MexicoAges 18 years+ - NCT04458545RecruitingPhase 1/Phase 2
Opioid vaccine study for adults with heroin or fentanyl use
This trial tests a vaccine made from parts designed to help the body respond to opioids (heroin or fentanyl). It is mainly for adults with moderate-to-severe opioid use disorder who are using opioids that match the study dosing needs and who are willing to do frequent visits over about a year.
Eatontown, New JerseyAges 18–59 - NCT04375033RecruitingPhase 4
Comparing Buprenorphine pill vs injection for opioid use disorder
This study compares two forms of a medication called buprenorphine (one is a pill you take under the tongue, the other is an injection) to see which works better for treating opioid use disorder. If you are eligible, you will receive one of these forms for a year and regular check-ups.
Tuscaloosa, AlabamaAges 18 years+ - NCT04354077Recruiting
Deep brain stimulation for opioid addiction
This study tests whether deep brain stimulation (DBS), a surgical treatment that uses electrical pulses to target specific brain areas, can help reduce cravings and relapse in people with opioid use disorder who haven't found relief from other treatments.
Pittsburgh, PennsylvaniaAges 22–65 - NCT07829263Recruiting
Brain stimulation with talk therapy for cocaine use disorder
This study tests whether a non-invasive brain stimulation method (high-definition transcranial direct current stimulation, or HD-tDCS) combined with cognitive behavioral therapy (a type of talk therapy) can help people reduce cocaine use. It explores if this combination is safe and practical.
Richmond, VirginiaAges 18–65 - NCT07825818RecruitingEarly Phase 1
Brain scan study for heavy drinkers
This study uses a special brain scan to look at how alcohol use affects energy production in brain cells. It may help researchers find new ways to treat alcohol use disorder.
Pittsburgh, PennsylvaniaAges 18–55 - NCT07612631RecruitingEarly Phase 1
Brain imaging study of alcohol and stress response
This research uses brain imaging to understand how two brain systems—one involved in stress and one involved in reward—interact in people with alcohol use disorder. The goal is to find new ways to help people reduce heavy drinking.
Pittsburgh, PennsylvaniaAges 18–55 - NCT07490600Recruiting
Testing brain stimulation and rewards for quitting cocaine
This trial combines deep transcranial magnetic stimulation (TMS) with a reward program (contingency management) to help people stop using cocaine. It may help if you are struggling with moderate to severe cocaine use and want a non-drug treatment.
Houston, TexasAges 18–65 - NCT07227948RecruitingPhase 2
Testing semaglutide for cocaine use disorder
This study tests whether semaglutide, a medication used for weight management, can help reduce cocaine use in people with cocaine use disorder. You may qualify if you have a body mass index (BMI) of 25 or higher and recently used cocaine.
Houston, TexasAges 18 years+ - NCT07226596Recruiting
Methamphetamine use: can you reduce without quitting?
This study tests whether people who use methamphetamine can reduce use even if they are not completely abstinent. It offers a 12-week program and checks how you're doing for another 12 weeks after.
Lexington, KentuckyAges 18 years+ - NCT06994338RecruitingPhase 2
Tirzepatide for alcohol use disorder
This study tests whether a medication called tirzepatide (a once-weekly injection) can help people reduce their alcohol consumption. It is for people who drink heavily, have a high BMI, and are actively seeking help to drink less.
Los Angeles, CaliforniaAges 21–65 - NCT06559995RecruitingPhase 2/Phase 3
Ketone drink for alcohol withdrawal
This study tests whether a special ketone drink can ease alcohol withdrawal and help your brain heal. If you have been drinking heavily for at least 3 years and are having withdrawal symptoms now, this might be an option for you.
Philadelphia, PennsylvaniaAges 18–65 - NCT06444256RecruitingPhase 2
Testing a sleep medication for people with stimulant use
This trial tests whether a medication that blocks a brain chemical involved in wakefulness can help people with stimulant use disorder sleep better. If you use cocaine or methamphetamine and have trouble sleeping, this study may be an option.
Houston, TexasAges 18–65 - NCT06399653Recruiting
Nerve stimulation for alcohol use disorder in veterans
This study tests a non-invasive device that gently stimulates a nerve in your neck (the vagus nerve) to see if it can help reduce alcohol cravings and improve daily functioning. It is designed for veterans who struggle with heavy drinking and want to explore a new treatment option.
San Diego, CaliforniaAges 21–65 - NCT06320366Recruiting
Faster TMS for methamphetamine use disorder
This study tests a faster brain stimulation technique (TMS) to help people reduce methamphetamine use. It may be a good option if you have moderate to severe methamphetamine use disorder and are looking for new treatment approaches.
Aurora, ColoradoAges 21–65 - NCT05827159RecruitingPhase 3
Medications started in the ER for alcohol use disorder
This study tests whether starting certain medications in the emergency room can help people with moderate to severe alcohol use disorder reduce heavy drinking and withdrawal problems after they leave the ER. It compares outcomes for participants who receive the study medications soon after an ER visit.
New Haven, ConnecticutAges 18–80 - NCT05781009RecruitingPhase 2
Pregnenolone treatment for alcohol use disorder
This Phase 2 study tests pregnenolone to help reduce or improve alcohol use disorder symptoms. It looks for adults who drink regularly and meet diagnostic criteria for moderate to severe alcohol use disorder, while excluding people with certain other substance use, medicines, or serious mental/medical conditions.
New Haven, ConnecticutAges 18–70 - NCT03667846RecruitingPhase 2
Biomarker-guided treatment for drinking and PTSD symptoms
This Phase 2 study tests whether blood/brain “biomarkers” can help choose a treatment plan for people who have alcohol use disorder and PTSD. The goal is to improve outcomes related to drinking and PTSD symptoms compared with a standard approach.
New York, New YorkAges 18–70
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Common questions
- Are there clinical trials for opioid use disorder, moderate?
- Yes. Clin2 currently lists 87 recruiting opioid use disorder, moderate studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use disorder, moderate trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use disorder, moderate trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.