Clinical trials
Osteoarthritis Knee Pain clinical trials
Below are recruiting osteoarthritis knee pain clinical trials, each written for real people, not researchers. We’re tracking 266 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05495334Recruiting
Add knee osteoarthritis outcomes to a patient registry
This study tests a new way to collect how people with knee osteoarthritis feel and function after usual care (like injections, nerve-blocking procedures, or knee replacement). It may help improve future treatment decisions by using your regular follow-up reports in an app or online.
Phoenix, ArizonaAges Any age - NCT06462560Recruiting
Live fitness program for knee osteoarthritis
This trial tests a live, interactive strength training program for people recently diagnosed with knee osteoarthritis. It aims to see if this home-based program can help reduce pain and improve daily function.
Murray, UtahAges 55–85 - NCT06466850Recruiting
Stem cell exosomes for knee osteoarthritis
This trial studies whether a natural substance called exosomes, derived from stem cells, can help reduce pain and improve function in people with knee osteoarthritis. It may be an option if other treatments have not worked well for you.
IsfahanAges 45–75 - NCT06685120Recruiting
PRP and hyaluronic acid for knee osteoarthritis
This study tests a combination of platelet-rich plasma (PRP) and hyaluronic acid injections for knee osteoarthritis. It aims to see if these injections together can reduce pain and improve function better than standard treatments.
BolognaAges 40–75 - NCT06932614Recruiting
Growth factor vs PRP for knee arthritis
This trial compares two injections—a special growth factor treatment and a platelet-rich plasma (PRP) injection—to see which works better for knee osteoarthritis. It aims to help people with mild to moderate knee arthritis who have had pain for at least 3 months.
TaipeiAges 20–80 - NCT07288970Recruiting
Comparing two numbing injections for knee replacement pain
This study compares two types of numbing injections (nerve blocks) to see which provides better pain relief after total knee replacement surgery. If you are 65 or older and having your first knee replacement, you may be able to join.
PoznanAges 65–100 - NCT07449442Recruiting
Pain relief study after knee replacement surgery
This trial tests a special injection around the knee to improve pain control after knee replacement surgery. It may help reduce the need for strong pain medicines.
PoznanAges 65–100 - NCT07134244Recruiting
Predicting cartilage damage and pain after knee injury or early arthritis
This study uses computer models and MRI scans to predict how knee cartilage and pain may change over time in people with early osteoarthritis or a recent ACL tear. It aims to find better ways to manage these conditions and prevent long-term damage.
Aalborg, North DenmarkAges 18–70 - NCT05917028Recruiting
Nonsurgical injections to reduce knee osteoarthritis pain
This study tests a procedure called transcatheter arterial micro-embolization (a targeted injection done through blood vessels) to lessen pain from knee osteoarthritis. It may help people who still have significant pain despite standard “non-surgical” treatments like therapy and joint injections.
Seoul, Seodaemun-guAges 50 years+ - NCT04318041RecruitingPhase 3
Diacerein to improve knee osteoarthritis symptoms
This Phase 3 study tests diacerein (Artrodar®) to see if it can improve symptoms in people with knee osteoarthritis, and it uses movement and scan-based assessments. It may help reduce walking pain and improve knee function for the right patient group.
Bangkoknoi, BangkokAges 40–65 - NCT05946044Recruiting
Preventing Knee Arthritis in People at Higher Risk
This study looks at ways to help prevent knee osteoarthritis before it starts. It is designed for women with higher body weight who currently have no arthritis signs on scans and do not have much knee pain.
Boston, MassachusettsAges 50 years+ - NCT07339111RecruitingPhase 3
CARTISTEM vs surgery for knee cartilage damage and osteoarthritis
This trial tests if a cell-based treatment called CARTISTEM can repair knee cartilage better than surgery alone. It involves people with knee osteoarthritis and a cartilage defect, with moderate pain and limited function.
Birmingham, AlabamaAges 18–75 - NCT07123805Recruiting
Acupuncture for knee replacement recovery
This study tests if adding acupuncture before and after knee replacement surgery helps reduce pain and improve recovery. It may be an option for people having planned knee replacement for osteoarthritis.
Pavia, PaviaAges 18 years+ - NCT06619340Enrolling by invitationPhase 4
Exparrel block for knee replacement pain relief
This trial tests a special numbing injection called an EXPAREL IPSA block to see how well it controls pain after knee replacement surgery. It is for people with knee arthritis who are having their first knee replacement under spinal anesthesia.
Germantown, TennesseeAges 18 years+ - NCT06488144RecruitingPhase 3
Knee arthritis rehab: helping veterans keep improving
This study tests a program that helps veterans with knee osteoarthritis keep up the gains they make in physical therapy. It uses a Fitbit and a smartphone app to support you and track your activity after your PT sessions end.
Birmingham, AlabamaAges 40–90 - NCT06686680Recruiting
Shockwave therapy for knee arthritis after ACL repair
This study tests whether shockwave therapy can help knee pain and function in people who developed knee osteoarthritis after an ACL reconstruction. If you had ACL surgery at least a year ago and still have knee pain, this treatment might offer a new option without surgery.
Cambridge, MassachusettsAges 18–55 - NCT07397806Recruiting
Home-based leg trainer for knee osteoarthritis
This study tests a home exercise device designed to improve leg control and reduce pain in people with knee osteoarthritis. You may be eligible if you have knee pain and are between 40 and 85 years old.
Vail, ColoradoAges 40–85 - NCT06637709Recruiting
Pain after osteoarthritis treatment: a 24-month study
This study looks at why some people still have pain after knee surgery or other treatments for osteoarthritis. It tests a marker in the blood to see if it relates to ongoing pain. You would be followed for 24 months.
Roma, RomaAges 18–99 - NCT05507099RecruitingPhase 2
Stem cell injections for knee or hip osteoarthritis pain
This Phase 2 study tests whether stem cell injections can reduce pain and improve symptoms in people with knee or hip osteoarthritis. You may be considered if you have moderate-to-severe pain despite trying standard treatments.
Brampton, OntarioAges 18–95 - NCT06088602Recruiting
Cold therapy for pain after knee replacement
This trial tests a cold treatment called cryoneurolysis to reduce pain after knee replacement surgery. It may help you move better and use less pain medication.
HvidovreAges 18 years+ - NCT06833749RecruitingPhase 2
Testing KBP-336 for knee osteoarthritis with obesity
This study tests an experimental medicine called KBP-336 for people with both obesity and knee osteoarthritis who still have significant knee pain despite standard treatments. It aims to see if KBP-336 can reduce pain and improve function.
BrnoAges 45 years+ - NCT06451783Enrolling by invitationEarly Phase 1
Herbal Medicine and Joint Manipulation for Knee Osteoarthritis
This trial tests a combination of a Chinese herbal formula (Shengyu Decoction) and a hands-on joint manipulation technique (Lijin Manipulation) to improve knee movement and reduce pain in people with knee osteoarthritis. It uses special 3D walking analysis to see how well the treatment works.
ShanghaiAges 45–85 - NCT06603103Recruiting
Comparing two knee implants in total knee replacement
This study compares two types of knee implants (SpheriKA and Origin) used in total knee replacement surgery with a specific alignment technique. The goal is to see which one may lead to better outcomes for patients needing a first knee replacement.
MérignacAges 18 years+ - NCT06623669RecruitingPhase 2
Mobile program to reduce pain and improve health in older adults
This trial tests a mobile program to help reduce pain and improve health in older adults with knee or hip arthritis who are not very active. The program involves exercise and may help with weight management.
Winston-Salem, North CarolinaAges 65 years+
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Common questions
- Are there clinical trials for osteoarthritis knee pain?
- Yes. Clin2 currently lists 266 recruiting osteoarthritis knee pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis knee pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis knee pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.