Clinical trials
Osteoarthritis Knee Pain clinical trials
Below are recruiting osteoarthritis knee pain clinical trials, each written for real people, not researchers. We’re tracking 268 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07329361Recruiting
Frozen platelet-rich plasma injections for knee osteoarthritis
This trial tests whether frozen platelet-rich plasma (PRP) injections into the knee can safely reduce pain and improve function in people with knee osteoarthritis. It's for those with mild to moderate knee arthritis who haven't had certain recent knee treatments.
Vitoria-Gasteiz, Araba/ÁlavaAges 40–85 - NCT06994546Recruiting
ArtiBest injection for knee osteoarthritis pain
This trial tests a new hyaluronic acid injection called ArtiBest for people with mild to moderate knee osteoarthritis who haven't gotten enough relief from other treatments like physical therapy or pain pills. It aims to see if the injection can reduce knee pain and improve function.
Kaohsiung CityAges 35–85 - NCT07426549Recruiting
Knee Exercises With Blood Flow Restriction for Osteoarthritis
This study compares two types of knee exercises (closed chain and open chain) with a special blood flow restriction technique to see which helps reduce pain and improve function in people with mild to moderate knee osteoarthritis.
RawalpindiAges 45–75 - NCT05254574RecruitingPhase 1
Acoustic therapy for ongoing joint pain from osteoarthritis
This Phase 1 study tests a sustained acoustic medicine device to help reduce pain from osteoarthritis (wear-and-tear arthritis) in joints like knees or hips. Because it’s early-stage research, you may be asked to follow strict rules about pain medicines and device use while the team monitors safety and comfort.
Tampa, FloridaAges 35–85 - NCT06857123Recruiting
Rest breaks during exercise for knee osteoarthritis
This study is testing whether adding short rest breaks during exercise can help people with knee osteoarthritis feel better and stick with a program. It may be a good option if you have mild to moderate knee pain and are not very active right now.
Pittsburgh, PennsylvaniaAges 45–79 - NCT07652437Recruiting
Wearable device study for knee osteoarthritis walking
This study tests whether a wearable device can help people with knee osteoarthritis walk more easily and for longer periods. If you have knee pain or stiffness on most days and find walking difficult, this might help you improve your mobility.
Cambridge, MassachusettsAges 21–100 - NCT06426251Recruiting
Light therapy for knee replacement recovery
This trial tests whether a special light therapy (photobiomodulation) can help reduce pain and speed healing after total knee replacement. If you're having knee replacement and don't have complications like infection or open wounds, you may be eligible.
HsinchuAges 20 years+ - NCT06991231Recruiting
Cryoablation benefits in knee replacement surgery
This trial tests if a special cold treatment (cryoablation) can help reduce pain or improve recovery for people getting knee replacement surgery for arthritis. It might offer an extra option to feel better after the procedure.
New York, New YorkAges 18 years+ - NCT07324746Recruiting
Herbal supplement for osteoarthritis pain
This trial tests whether a herbal supplement helps people with osteoarthritis of the knee or hip feel less pain and move better. If you have moderate to severe pain and are able to walk, this study might be a good fit.
LondonAges 18 years+ - NCT07721116Recruiting
AI Study of Knee Imaging and Treatment Results
This study uses artificial intelligence (AI) to better understand knee images from healthy people and those with knee arthritis. It aims to predict how well knee injections might work for you.
Taipei, TaiwanAges 18 years+ - NCT07313020Enrolling by invitationEarly Phase 1
Handheld imaging to track stem cells in knee osteoarthritis
This trial tests a new handheld imaging device (MPI) to track stem cells injected into the knee. It aims to see if the device can safely monitor how the stem cells move and work in people with knee osteoarthritis.
Haikou, HainanAges 18–75 - NCT03383081RecruitingPhase 2
Stem cell injection for moderate knee osteoarthritis pain
This Phase 2 study tests whether injected umbilical-cord stem cells can improve safety and reduce symptoms in people with moderate knee osteoarthritis. It focuses on people with significant knee pain who have not gotten enough relief from standard, non-procedure treatments.
Changsha, HunanAges Up to 70 years - NCT07701174Recruiting
Weighted exercise vs muscle stimulation for knee arthritis
This study compares two treatments for knee osteoarthritis: weighted dangling exercises and neuromuscular electrical stimulation of the knee muscle. It aims to see which one reduces pain and improves function better.
Lahore, Punjab ProvinceAges 40–60 - NCT05517434RecruitingPhase 2/Phase 3
Autologous bone and fat injections versus saline for knee OA
This trial compares different knee injections made from your own bone marrow and/or fat, plus platelet-rich plasma (a blood-derived healing factor), against saline (placebo) to treat painful knee osteoarthritis. It aims to see whether these “autologous” injections reduce knee pain and improve function.
Toronto, OntarioAges 30 years+ - NCT06040827Recruiting
Study of a knee implant extension for knee replacement
This trial is for adults having their first knee replacement surgery. It tests a special part (tibial extension) of a common knee implant system. Researchers will follow participants over time to see how well it works.
Fayetteville, ArkansasAges 18 years+ - NCT06336447Recruiting
Virtual reality and nerve block for chronic knee pain
This study tests whether using virtual reality (VR) before a standard heat-based nerve block (radiofrequency ablation) can improve relief of long-term knee pain caused by arthritis. If you qualify, you'll receive the RFA procedure and may be randomly assigned to also use VR.
Chicago, IllinoisAges 18 years+ - NCT06507046Recruiting
Personalized total knee replacement study in Norway
This trial is studying a more personalized approach to total knee replacement surgery. It is for people with moderate to severe knee arthritis who are already scheduled for a knee replacement at Kristiansund Hospital in Norway.
Kristiansund, Møre and RomsdalAges 18–80 - NCT06557018RecruitingPhase 4
Numbing medicine injection for knee replacement pain
This study tests a long-lasting numbing medicine (liposomal bupivacaine) injected around the knee during total knee replacement surgery. It aims to see if this medicine helps control pain and reduce the need for other painkillers after surgery.
Dezhou, ShandongAges 18–80 - NCT06643845Recruiting
Can medical treatments delay or avoid knee replacement?
This trial tests whether a combination of non-surgical treatments can help people with knee osteoarthritis avoid or delay total knee replacement surgery. It may be an option if you are considering knee replacement but want to explore medical alternatives first.
AmiensAges 18–90 - NCT06490770Recruiting
Understanding knee pain and function
This study looks at how your knee joint works when you have pain or limited function. It uses MRI and electrical stimulation to learn more about cartilage and meniscus damage, which might help improve future treatments.
BolognaAges 18–60 - NCT05981105Recruiting
Recovery and Chronic Pain After Knee Replacement
This study tests a special recovery program after knee replacement surgery to see if it helps reduce long-term pain. You may be eligible if you are having a first-time knee replacement for osteoarthritis, are between 18 and 65, and live near the hospital.
New York, New YorkAges 18–75 - NCT07281651Recruiting
Understanding pain sensitivity in knee pain and fibromyalgia
This study looks at how the brain and nerves process pain in people with knee pain or fibromyalgia. It compares them to pain-free people to understand differences in muscle signals.
Derby, DerbyshireAges 40 years+ - NCT03048201Recruiting
Total Knee Replacement Registry Study for a Specific Knee Implant
This study tracks outcomes for people getting a total knee replacement using a specific knee implant system. It may help doctors understand which patients do best and how the implant performs over time.
Rancho Mirage, CaliforniaAges 22 years+ - NCT04716803Recruiting
BMAC injection for severe knee osteoarthritis before knee surgery
This trial studies injecting “bone marrow aspirate concentrate” (BMAC) into the knee to help relieve pain from severe knee osteoarthritis. It’s for people who have strong signs of advanced arthritis on X-ray and still have ongoing pain despite usual treatments, before a planned knee procedure.
La Jolla, CaliforniaAges 45–75
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Common questions
- Are there clinical trials for osteoarthritis knee pain?
- Yes. Clin2 currently lists 268 recruiting osteoarthritis knee pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis knee pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis knee pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.