Clinical trials
Osteoarthritis (OA) of the Knee clinical trials
Below are recruiting osteoarthritis (oa) of the knee clinical trials, each written for real people, not researchers. We’re tracking 151 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06280352Recruiting
Robotic vs custom knee replacement trial
This study compares two modern ways of doing knee replacement: robot-assisted surgery versus a custom-made implant tailored to your knee shape. It aims to see which approach leads to better recovery and function for people with osteoarthritis.
Graz, StyriaAges 40–90 - NCT07592871Recruiting
Knee Injury and Arthritis Long-Term Health Study
This study follows patients with knee injuries or wear-and-tear arthritis over time to understand how these conditions develop and change. Your health information helps doctors learn what treatments work best and how to prevent problems.
Ningbo, ZhejiangAges 18–90 - NCT06885372Enrolling by invitation
Long-term follow-up of ACL tear patients without surgery
This trial is for people with a torn ACL who are young (up to 25) and have certain risk factors for knee instability. It will follow them long-term to see how their knee does without surgery, focusing on those who are active in pivoting sports, have a loose knee joint, or have naturally loose joints.
Banff, AlbertaAges 14–25 - NCT07509307RecruitingPhase 3
Study of a new medicine for weight loss and knee pain in osteoarthritis
This trial tests if a new medicine, NNC0487-0111, can help people with excess weight and knee osteoarthritis lose weight and reduce knee pain. It is for people who have had knee pain for at least three months and who can stop taking pain relievers for short periods before study visits.
Escondido, CaliforniaAges 18 years+ - NCT07855367Recruiting
Knee pain relief study for osteoarthritis patients
This study compares two procedures that use extreme cold or heat to target the nerves around the knee, with the goal of reducing pain from knee osteoarthritis. It is specifically for people with advanced knee osteoarthritis who also have bladder cancer.
CairoAges 40 years+ - NCT07551245Recruiting
High-intensity laser vs traditional treatment for knee osteoarthritis
This study tests whether high-intensity laser therapy works better than traditional physical therapy methods for knee osteoarthritis pain and function. You'll be randomly assigned to receive either laser treatments or standard rehabilitation exercises.
Erbil, Erbil GovernorateAges 30–60 - NCT06478186RecruitingPhase 4
Knee Osteoarthritis Steroid Injection Study for People with Type 2 Diabetes
This study compares two different steroid knee injections—Zilretta and Kenalog—to see which works better for people with both knee osteoarthritis and type 2 diabetes. It uses a continuous glucose monitor to track blood sugar changes.
Kansas City, KansasAges 40 years+ - NCT06616896Recruiting
Vibration exercise for knee osteoarthritis
This study tests whether a special vibrating exercise program can improve knee pain and function in people with knee osteoarthritis. It compares this new rehab approach to standard exercise.
TaipeiAges 50–80 - NCT06994546Recruiting
ArtiBest injection for knee osteoarthritis pain
This trial tests a new hyaluronic acid injection called ArtiBest for people with mild to moderate knee osteoarthritis who haven't gotten enough relief from other treatments like physical therapy or pain pills. It aims to see if the injection can reduce knee pain and improve function.
Kaohsiung CityAges 35–85 - NCT06857123Recruiting
Rest breaks during exercise for knee osteoarthritis
This study is testing whether adding short rest breaks during exercise can help people with knee osteoarthritis feel better and stick with a program. It may be a good option if you have mild to moderate knee pain and are not very active right now.
Pittsburgh, PennsylvaniaAges 45–79 - NCT07796607Enrolling by invitation
Knee cartilage therapy research
This study looks at knee osteoarthritis to find new ways to treat it. If you have knee pain from worn-down cartilage, this research may lead to better therapies.
Kunming, YunnanAges Any age - NCT07767409Recruiting
Home exercise app versus clinic physiotherapy for knee arthritis
This study compares doing exercises and self-care through a smartphone app to attending physiotherapy at a hospital clinic for people with knee osteoarthritis. It aims to see if the app is as helpful for reducing pain and improving function.
SingaporeAges 45–95 - NCT07472088Recruiting
Knee pain study using weight-bearing CT scans
This trial uses a special CT scan taken while you stand to see how the shape of your knee joint relates to your knee pain. It may help researchers better understand knee arthritis and front-of-knee pain.
Kansas City, KansasAges 18 years+ - NCT07055113Recruiting
Home rehab program for hip or knee arthritis
This study tests a home-based rehab program for people with hip or knee arthritis who do not need joint replacement yet. It aims to help improve function and reduce pain through online sessions.
Edmonton, AlbertaAges Any age - NCT06370312Recruiting
Biomarkers for thumb osteoarthritis surgery
This study looks at joint fluid and tissue samples from people with thumb base osteoarthritis who are already scheduled for a surgery called trapeziectomy. The goal is to find markers that might help better understand the disease and improve treatment.
Malmö, Skåne CountyAges 25 years+ - NCT05946044Recruiting
Preventing Knee Arthritis in People at Higher Risk
This study looks at ways to help prevent knee osteoarthritis before it starts. It is designed for women with higher body weight who currently have no arthritis signs on scans and do not have much knee pain.
Boston, MassachusettsAges 50 years+ - NCT04875052Recruiting
Study vibration after ACL injury and future arthritis risk
This study looks at whether using vibration after an ACL injury helps predict or reduce the risk of developing post-traumatic osteoarthritis (wear-and-tear arthritis) later. It may help researchers learn which patients are more likely to develop arthritis after ACL reconstruction.
Chapel Hill, North CarolinaAges 16–35 - NCT06686680Recruiting
Shockwave therapy for knee arthritis after ACL repair
This study tests whether shockwave therapy can help knee pain and function in people who developed knee osteoarthritis after an ACL reconstruction. If you had ACL surgery at least a year ago and still have knee pain, this treatment might offer a new option without surgery.
Cambridge, MassachusettsAges 18–55 - NCT06833749RecruitingPhase 2
Testing KBP-336 for knee osteoarthritis with obesity
This study tests an experimental medicine called KBP-336 for people with both obesity and knee osteoarthritis who still have significant knee pain despite standard treatments. It aims to see if KBP-336 can reduce pain and improve function.
BrnoAges 45 years+ - NCT05507099RecruitingPhase 2
Stem cell injections for knee or hip osteoarthritis pain
This Phase 2 study tests whether stem cell injections can reduce pain and improve symptoms in people with knee or hip osteoarthritis. You may be considered if you have moderate-to-severe pain despite trying standard treatments.
Brampton, OntarioAges 18–95 - NCT07367126Recruiting
Nerve pain in knee osteoarthritis: Pain and function study
This study looks at nerve-related pain in people with knee osteoarthritis and how it affects their pain level and daily function. It may help understand if nerve pain is a key factor in your knee OA symptoms.
IstanbulAges 40–70 - NCT06906939RecruitingEarly Phase 1
Brain stimulation and tai chi for knee arthritis and depression
This pilot study tests if combining brain stimulation (rTMS) with Tai Chi can help knee arthritis pain and improve depression. It compares these two treatments to see which works better for people with both pain and low mood.
Los Angeles, CaliforniaAges 50–95 - NCT07134244Recruiting
Predicting cartilage damage and pain after knee injury or early arthritis
This study uses computer models and MRI scans to predict how knee cartilage and pain may change over time in people with early osteoarthritis or a recent ACL tear. It aims to find better ways to manage these conditions and prevent long-term damage.
Aalborg, North DenmarkAges 18–70 - NCT06090097Recruiting
Game therapy for knee osteoarthritis
This trial tests a game-based therapy that uses biofeedback to help strengthen your knee. It may help you move better and feel less pain.
Chapel Hill, North CarolinaAges 30–75
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Common questions
- Are there clinical trials for osteoarthritis (oa) of the knee?
- Yes. Clin2 currently lists 151 recruiting osteoarthritis (oa) of the knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis (oa) of the knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis (oa) of the knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.