Clinical trials · Los Angeles, CA
Osteoarthritis clinical trials in Los Angeles
We’re tracking 20 recruiting osteoarthritis studies with a site in or near Los Angeles — including Early Phase 1, Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Los Angeles
- NCT05495334Recruiting
Add knee osteoarthritis outcomes to a patient registry
This study tests a new way to collect how people with knee osteoarthritis feel and function after usual care (like injections, nerve-blocking procedures, or knee replacement). It may help improve future treatment decisions by using your regular follow-up reports in an app or online.
Los Angeles, CaliforniaAges Any age - NCT06906939RecruitingEarly Phase 1
Brain stimulation and tai chi for knee arthritis and depression
This pilot study tests if combining brain stimulation (rTMS) with Tai Chi can help knee arthritis pain and improve depression. It compares these two treatments to see which works better for people with both pain and low mood.
Los Angeles, CaliforniaAges 50–95 - NCT05587244Enrolling by invitation
Hip liner study for people getting a hip replacement
This study looks at a specific type of hip replacement liner (the part inside the hip joint) and how well it works after surgery. You might be eligible if you’re planning a one-sided hip replacement and don’t have certain infection, bone, or health problems that could affect healing.
Los Angeles, CaliforniaAges 18–80 - NCT07308834RecruitingPhase 1/Phase 2
Knee injection study for moderate to severe osteoarthritis pain
This study tests a new knee injection called CX-011 to see if it can reduce pain and improve function in people with knee osteoarthritis. It may be a good option if you have tried other treatments without enough relief.
Los Angeles, CaliforniaAges 40–75 - NCT03968913RecruitingEarly Phase 1
Biologic shot to prevent knee arthritis after ACL injury
This early-phase trial tests a biologic medicine (anakinra) given after an ACL injury to try to prevent or reduce later osteoarthritis (wear-and-tear arthritis). It enrolls young adults who recently tore their ACL and are planning a specific type of ACL reconstruction.
Los Angeles, CaliforniaAges 18–35 - NCT06608134RecruitingEarly Phase 1
Umbilical cord injection for knee osteoarthritis pain
This trial tests whether a special injection made from umbilical cord tissue can safely help with knee osteoarthritis pain. If you have moderate knee arthritis and haven't had recent injections or surgery, you may be able to join.
Beverly Hills, CaliforniaAges 30 years+ - NCT06884865RecruitingPhase 2
Study of an experimental knee injection for osteoarthritis pain
This study tests a new investigational medicine injected into the knee to see if it is safe and tolerable for people with painful knee osteoarthritis. It may help reduce pain and improve knee function.
Beverly Hills, CaliforniaAges 45–80 - NCT07339111RecruitingPhase 3
CARTISTEM vs surgery for knee cartilage damage and osteoarthritis
This trial tests if a cell-based treatment called CARTISTEM can repair knee cartilage better than surgery alone. It involves people with knee osteoarthritis and a cartilage defect, with moderate pain and limited function.
Santa Monica, CaliforniaAges 18–75 - NCT06917404RecruitingPhase 3
Knee osteoarthritis pain study: comparing a new injection to placebo
This phase 3 study tests whether a medicine called pentosan polysulfate sodium (PPS), given as a shot under the skin, reduces pain in people with knee osteoarthritis. It compares PPS to a placebo (a shot with no active medicine) to see if it is safe and effective.
Cerritos, CaliforniaAges 18 years+ - NCT07219771RecruitingPhase 3
Testing MOTYS injection for knee osteoarthritis pain
This trial tests an injection called PTP-001 (MOTYS) for people with mild to moderate knee osteoarthritis. It aims to see if the injection can reduce knee pain and improve function.
West Hills, CaliforniaAges 40–80 - NCT05211986RecruitingPhase 1/Phase 2
Test injection safety for knee osteoarthritis muscle weakness
This Phase 1/2 trial studies whether an injection called IMM01-STEM is safe and well-tolerated for people with knee osteoarthritis who also have muscle weakness. It also looks at whether the treatment could help in this group, while carefully monitoring side effects.
Orange, CaliforniaAges 50–75 - NCT07353931RecruitingPhase 3
Study of eloralintide for knee osteoarthritis pain in people with overweight or obesity
This trial tests an investigational drug called eloralintide to see if it can reduce knee pain in people with osteoarthritis who also have overweight or obesity. You may be able to join if you have knee osteoarthritis, a BMI of 27 or higher, and have tried to lose weight with diet before.
Fountain Valley, CaliforniaAges 18 years+ - NCT07153471RecruitingPhase 3
A study of an experimental pill for weight loss and knee arthritis
This trial tests an investigational medication (orforglipron) to see if it helps people with knee arthritis lose weight. You may qualify if you have overweight or obesity and have tried dieting before without lasting success.
Huntington Beach, CaliforniaAges 18 years+ - NCT04238143Recruiting
Knee and other joint arthritis tissue therapy
This trial tests a regenerative therapy made from a patient’s own fat tissue (a “cellular” treatment) to reduce pain and improve function in arthritis-related problems. It may help people with inflammatory or degenerative arthritis changes, if they meet safety and tissue-donation requirements.
Valencia, CaliforniaAges 18–90 - NCT05986292RecruitingPhase 2
Study of new treatments for chronic pain
This study tests new treatments for chronic pain that lasts at least 3 months. Participants must stop their regular pain medicines and use only a rescue painkiller if needed. The goal is to find better ways to manage long-term pain.
Irvine, CaliforniaAges 18 years+ - NCT04984291Recruiting
Study of shoulder replacement implants for eligible adults
This trial looks at a specific shoulder replacement implant and follow-up care for people who need a shoulder arthroplasty (shoulder replacement) for certain joint problems or fractures. You may be a candidate if you can take part in required visits and your shoulder muscles and bone are suitable.
Irvine, CaliforniaAges 20 years+ - NCT05603728Recruiting
Follow-up study for Exactech shoulder implants after surgery
This study follows people who get (or already had) a shoulder replacement to see how the implant is doing over time. It may help improve future care by tracking long-term performance and safety.
Laguna Woods, CaliforniaAges 21 years+ - NCT07509307RecruitingPhase 3
Study of a new medicine for weight loss and knee pain in osteoarthritis
This trial tests if a new medicine, NNC0487-0111, can help people with excess weight and knee osteoarthritis lose weight and reduce knee pain. It is for people who have had knee pain for at least three months and who can stop taking pain relievers for short periods before study visits.
Lancaster, CaliforniaAges 18 years+ - NCT07641517RecruitingPhase 2
Testing LY4065967 for chronic knee osteoarthritis pain
This study tests an experimental drug called LY4065967 to see if it can help reduce pain from osteoarthritis in the knee. You'll be in the trial for several months, with regular check-ins and pain assessments.
Riverside, CaliforniaAges 40 years+ - NCT05719935Recruiting
KinematX wrist replacement registry for people with wrist arthritis
This trial is a registry that follows people who get (or already had) a KinematX total wrist replacement. It collects health and recovery information to better understand outcomes for different wrist problems, like arthritis or certain bone alignment issues.
Loma Linda, CaliforniaAges 18–85
Hear when a new Osteoarthritis trial opens near Los Angeles, CA
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Osteoarthritis trials in other cities
Where these studies are running near Los Angeles
Institutions with a site for the recruiting osteoarthritis studies listed above.
- Focus Clinical Research · 3 studies
- Artemis Institute for Clinical Research · 2 studies
- Source Healthcare · 2 studies
- University of California, Los Angeles (UCLA) · 2 studies
- University of Southern California · 2 studies
- Ark Clinical Research
- Beach Physicians Medical Group Inc.
- Care Access
What taking part in a osteoarthritis study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting osteoarthritis studies in California.
Common questions
- Are there osteoarthritis clinical trials near Los Angeles?
- Yes. We're currently tracking 20 recruiting osteoarthritis studies with a site near Los Angeles, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a osteoarthritis study near Los Angeles?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Los Angeles to take part?
- Not necessarily. These studies have a site near Los Angeles, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New osteoarthritis studies open near Los Angeles regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.