Clinical trials · Chicago, IL
Osteoarthritis clinical trials in Chicago
We’re tracking 28 recruiting osteoarthritis studies with a site in or near Chicago — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Chicago
- NCT07353931RecruitingPhase 3
Study of eloralintide for knee osteoarthritis pain in people with overweight or obesity
This trial tests an investigational drug called eloralintide to see if it can reduce knee pain in people with osteoarthritis who also have overweight or obesity. You may be able to join if you have knee osteoarthritis, a BMI of 27 or higher, and have tried to lose weight with diet before.
Chicago, IllinoisAges 18 years+ - NCT06968143Recruiting
Patient Satisfaction With Smart Knee Implants Trial
This trial looks at how satisfied patients are with a new 'smart' knee implant that tracks motion and function. If you are getting a total knee replacement, you might be able to join and help compare the smart implant with standard implants.
Chicago, IllinoisAges 18 years+ - NCT04828954Recruiting
Testing different immobilization plans after thumb joint surgery
This study compares different ways of keeping your thumb still (immobilizing it) after thumb base joint surgery. It aims to see which immobilization approach leads to better recovery and hand function.
Chicago, IllinoisAges 40 years+ - NCT07537153Recruiting
Blocking Blood Vessels to Reduce Knee Arthritis Pain
This trial tests a procedure called genicular artery embolization, which blocks small blood vessels around the knee to reduce pain from moderate arthritis. It may help people whose knee pain hasn't improved with medications.
Chicago, IllinoisAges 40–80 - NCT06884865RecruitingPhase 2
Study of an experimental knee injection for osteoarthritis pain
This study tests a new investigational medicine injected into the knee to see if it is safe and tolerable for people with painful knee osteoarthritis. It may help reduce pain and improve knee function.
Chicago, IllinoisAges 45–80 - NCT05986292RecruitingPhase 2
Study of new treatments for chronic pain
This study tests new treatments for chronic pain that lasts at least 3 months. Participants must stop their regular pain medicines and use only a rescue painkiller if needed. The goal is to find better ways to manage long-term pain.
Chicago, IllinoisAges 18 years+ - NCT06843980Recruiting
Knee implant trial for inner knee pain
This trial tests a knee implant for people with pain on the inner side of the knee that gets worse with activity. It may be an option if other non-surgical treatments haven't helped.
Chicago, IllinoisAges Any age - NCT07641517RecruitingPhase 2
Testing LY4065967 for chronic knee osteoarthritis pain
This study tests an experimental drug called LY4065967 to see if it can help reduce pain from osteoarthritis in the knee. You'll be in the trial for several months, with regular check-ins and pain assessments.
Chicago, IllinoisAges 40 years+ - NCT04949087Recruiting
Shoulder arthritis injection study for ongoing pain relief
This trial looks at how well medicine given directly into the shoulder joint reduces pain from primary shoulder osteoarthritis. If you have ongoing shoulder pain confirmed by X-ray, you may be eligible to receive an in-joint injection and be followed for response.
Chicago, IllinoisAges 18 years+ - NCT06781463Recruiting
Knee arthritis treatment registry
This study tracks patients with knee arthritis who undergo a procedure called genicular artery embolization (GAE), a minimally invasive option for those not ready for or not eligible for knee replacement. The goal is to see how well GAE works for pain relief.
Chicago, IllinoisAges 18 years+ - NCT06617871Recruiting
Comparing two ways to align a new knee replacement
This study compares two different techniques (mechanical alignment vs. kinematic alignment) used during knee replacement surgery with a special knee system. It aims to see which technique leads to better results for patients.
Chicago, IllinoisAges 21–79 - NCT07003113Recruiting
Blood flow therapy for knee and back pain
This study tests a treatment called ischemic preconditioning, which uses a blood pressure cuff to temporarily restrict blood flow to your leg. It may help reduce pain from osteoarthritis in the knee or chronic back pain.
Chicago, IllinoisAges 50 years+ - NCT07153471RecruitingPhase 3
A study of an experimental pill for weight loss and knee arthritis
This trial tests an investigational medication (orforglipron) to see if it helps people with knee arthritis lose weight. You may qualify if you have overweight or obesity and have tried dieting before without lasting success.
Chicago, IllinoisAges 18 years+ - NCT07219771RecruitingPhase 3
Testing MOTYS injection for knee osteoarthritis pain
This trial tests an injection called PTP-001 (MOTYS) for people with mild to moderate knee osteoarthritis. It aims to see if the injection can reduce knee pain and improve function.
Chicago, IllinoisAges 40–80 - NCT04984291Recruiting
Study of shoulder replacement implants for eligible adults
This trial looks at a specific shoulder replacement implant and follow-up care for people who need a shoulder arthroplasty (shoulder replacement) for certain joint problems or fractures. You may be a candidate if you can take part in required visits and your shoulder muscles and bone are suitable.
Chicago, IllinoisAges 20 years+ - NCT06859164RecruitingPhase 2
Knee artery treatment for chronic osteoarthritis pain
This trial tests a procedure called genicular artery embolization to reduce pain in people with knee osteoarthritis that hasn't improved with other treatments. The goal is to see if blocking certain blood vessels can relieve pain and help you avoid or delay knee replacement surgery.
Chicago, IllinoisAges 40–80 - NCT07224958Recruiting
Knee brace for inner knee arthritis: a study
This study tests whether wearing a special knee brace for at least 4 hours a day can help reduce pain and improve function in people with arthritis in the inner part of the knee. It compares wearing a brace to not wearing one, so you could help find out if braces are a good option for managing knee pain.
Chicago, IllinoisAges 40–85 - NCT05985785Recruiting
Bone Marrow vs Steroid Injection for Knee Arthritis
This study compares two different knee injections—one using your own concentrated bone marrow cells (BMAC) and the other using a steroid (cortisone)—to see which works better for long-term knee pain from osteoarthritis.
Chicago, IllinoisAges 18–70 - NCT06245109RecruitingPhase 4
Pain medicine study for knee osteoarthritis
This study tests how well different pain medicines work for knee osteoarthritis and looks at brain patterns to understand why some people get more relief. It may help you find a treatment that works best for you.
Chicago, IllinoisAges 41 years+ - NCT06917404RecruitingPhase 3
Knee osteoarthritis pain study: comparing a new injection to placebo
This phase 3 study tests whether a medicine called pentosan polysulfate sodium (PPS), given as a shot under the skin, reduces pain in people with knee osteoarthritis. It compares PPS to a placebo (a shot with no active medicine) to see if it is safe and effective.
Chicago, IllinoisAges 18 years+ - NCT06729983Recruiting
Tendon lengthening during reverse shoulder replacement
This study tests whether slightly lengthening a tendon during reverse shoulder replacement improves outcomes. It's for adults getting their first reverse replacement at Loyola sites.
Maywood, IllinoisAges 18 years+ - NCT07509307RecruitingPhase 3
Study of a new medicine for weight loss and knee pain in osteoarthritis
This trial tests if a new medicine, NNC0487-0111, can help people with excess weight and knee osteoarthritis lose weight and reduce knee pain. It is for people who have had knee pain for at least three months and who can stop taking pain relievers for short periods before study visits.
Skokie, IllinoisAges 18 years+ - NCT03491761RecruitingPhase 2
PRP injection versus hyaluronic acid shots for knee arthritis
This trial tests whether a platelet-rich plasma (PRP) shot works better than a standard hyaluronic acid (“gel”) injection to reduce knee osteoarthritis pain. It may help people with ongoing knee pain choose the treatment that relieves symptoms more effectively.
Skokie, IllinoisAges 18–75 - NCT07118501Recruiting
Study of the Incompass total ankle system
This study is testing a new ankle replacement device called Incompass. It aims to see how well the device works and how safe it is for people who need ankle replacement surgery.
Morton Grove, IllinoisAges 21 years+
Hear when a new Osteoarthritis trial opens near Chicago, IL
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Osteoarthritis trials in other cities
Where these studies are running near Chicago
Institutions with a site for the recruiting osteoarthritis studies listed above.
- Northwestern University · 7 studies
- Rush University Medical Center · 5 studies
- University of Chicago · 4 studies
- Chicago Clinical Research Institute INC
- Chicago Clinical Research, Inc
- Clinical Investigation Specialists, Inc
- Evanston Premier Healthcare Research
- Genesis Orthopedics & Sports Medicine
What taking part in a osteoarthritis study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting osteoarthritis studies in Illinois.
Common questions
- Are there osteoarthritis clinical trials near Chicago?
- Yes. We're currently tracking 28 recruiting osteoarthritis studies with a site near Chicago, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a osteoarthritis study near Chicago?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Chicago to take part?
- Not necessarily. These studies have a site near Chicago, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New osteoarthritis studies open near Chicago regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.