Clinical trials
Osteoarthritis clinical trials
Below are recruiting osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 592 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06084364RecruitingPhase 4
Steroid vs saline injection vs occupational therapy for thumb arthritis
This study compares a steroid injection (Kenacort), a saltwater (saline) injection, and occupational therapy to see which works best for thumb base osteoarthritis pain. It may help you if you have thumb pain with swelling and want to avoid surgery.
BodøAges 40–85 - NCT06040957Recruiting
Bone marrow vs fat cells for knee osteoarthritis treatment
This trial compares using cells from your bone marrow or belly fat to treat knee osteoarthritis, aiming to reduce pain and improve function. It's for people who haven't gotten better with standard treatments like physical therapy or medications.
BolognaAges 40–75 - NCT05946044Recruiting
Preventing Knee Arthritis in People at Higher Risk
This study looks at ways to help prevent knee osteoarthritis before it starts. It is designed for women with higher body weight who currently have no arthritis signs on scans and do not have much knee pain.
Boston, MassachusettsAges 50 years+ - NCT05848622Recruiting
Gait retraining after ACL surgery for fast knee recovery
This trial tests a walking (gait) rehabilitation program to improve how you move after ACL reconstruction. It may help if you are still having walking mechanics issues in the months to years after surgery.
Chapel Hill, North CarolinaAges 16–35 - NCT05829733Recruiting
Synolis injection for 6 months in hip arthritis pain
This trial studies whether a treatment injection (Synolis VA 80/160) can safely reduce hip arthritis pain and improve function over 6 months. You may be eligible if you have confirmed hip osteoarthritis, ongoing pain despite common pain medicines, and no recent steroid or “visco-supplement” injections in that hip.
BelfortAges 18 years+ - NCT03383081RecruitingPhase 2
Stem cell injection for moderate knee osteoarthritis pain
This Phase 2 study tests whether injected umbilical-cord stem cells can improve safety and reduce symptoms in people with moderate knee osteoarthritis. It focuses on people with significant knee pain who have not gotten enough relief from standard, non-procedure treatments.
Changsha, HunanAges Up to 70 years - NCT04937998Recruiting
PRP or hyaluronic acid injections for knee cartilage pain
This trial compares two injection treatments—platelet-rich plasma (PRP) and hyaluronic acid (HA)—for pain from osteoarthritis in the kneecap area. It looks to see which injection works better and for whom, using symptom follow-up and imaging.
BolognaAges 30–65 - NCT05675527RecruitingPhase 4
Platelet gel (PRP) for shoulder arthritis pain
This trial tests whether platelet-rich plasma (PRP), a blood-based treatment, can reduce pain from shoulder (glenohumeral) osteoarthritis. It also looks at whether PRP works for people who had temporary relief from a numbing/shock injection into the joint.
New York, New YorkAges 18–100 - NCT05593640Recruiting
Thromboxane A2 and Knee Osteoarthritis Study
This trial is studying a substance called thromboxane A2 in people with knee osteoarthritis and joint swelling. It aims to help doctors better understand this condition and find new ways to treat it.
NiceAges 40 years+ - NCT05543941Recruiting
Test advanced irrigation during knee, hip, or shoulder replacement
This trial studies a cleaning solution used during surgery to lower the risk of complications and improve outcomes after joint replacement. It may be an option if you’re having a planned knee, hip, or humerus (shoulder) replacement and meet the specific health and allergy requirements.
Vancouver, British ColumbiaAges 18 years+ - NCT05507099RecruitingPhase 2
Stem cell injections for knee or hip osteoarthritis pain
This Phase 2 study tests whether stem cell injections can reduce pain and improve symptoms in people with knee or hip osteoarthritis. You may be considered if you have moderate-to-severe pain despite trying standard treatments.
Brampton, OntarioAges 18–95 - NCT05488093Recruiting
Testing knee movement in severe knee arthritis before replacement surgery
This study checks how well your knee moves and how that relates to pain and function in people with severe knee arthritis who are about to get total knee replacement. It may help doctors better plan and evaluate treatment before surgery.
MontpellierAges 60 years+ - NCT05267093Recruiting
Acupuncture for hand osteoarthritis pain
This study compares real acupuncture to sham (placebo) acupuncture to see which one better reduces pain and improves function in people with hand osteoarthritis. It may help you understand whether acupuncture provides meaningful relief beyond placebo.
BeijingAges 18–80 - NCT05039463Recruiting
Platelet-Rich Plasma and Hyaluronic Acid for Knee Arthritis
This trial tests whether combining two types of injections—platelet-rich plasma (a concentration of healing cells from your own blood) and hyaluronic acid (a natural lubricant)—can reduce knee osteoarthritis pain and improve function over one year. You're eligible if you've already received or are about to receive these injections at Amiens University Hospital.
AmiensAges 18 years+ - NCT04990128RecruitingPhase 3
Bone marrow fluid injection versus steroid shots for hip arthritis
This trial compares a “bone marrow aspirate concentrate” injection with a corticosteroid (steroid) injection to reduce pain from hip osteoarthritis. It aims to see which treatment works better over time for hip pain and function.
Weston, FloridaAges 18–75 - NCT04929951RecruitingPhase 1
Micro fat injection to treat shoulder arthritis
This Phase 1 study tests whether a micro-fragmented fat (MFAT) injection can reduce symptoms and improve shoulder function in people with shoulder osteoarthritis. It’s early research, so the goal is mainly to see if the treatment is safe and possibly helpful.
Stanford, CaliforniaAges 25–75 - NCT04998188Recruiting
Hydrolyzed collagen for one knee with osteoarthritis
This trial tests whether a hydrolyzed collagen drink or supplement can reduce knee pain and symptoms compared with a placebo (inactive treatment) in people with osteoarthritis. It may help if you’ve tried standard non-surgical treatments and still have ongoing knee trouble.
BolognaAges 18–75 - NCT04651673Enrolling by invitation
Knee brace program for adults with knee osteoarthritis pain
This trial looks at using a prescribed knee brace to help relieve knee pain and symptoms from knee osteoarthritis. You may be able to join if your knee braces are being provided through participating clinics and you can consent and complete study questionnaires.
Hässleholm, Skåne CountyAges 18–100 - NCT04472702Recruiting
Ultrasound vs X-ray guidance for knee pain ablation
This trial compares two ways (ultrasound or X-ray guidance) to place a treatment for painful knee arthritis. It aims to see whether one guidance method works as well as the other for reducing knee pain.
Sacramento, CaliforniaAges 35–99 - NCT03734900RecruitingPhase 4
Comparing two knee injection treatments for osteoarthritis
This study compares two knee injection treatments for knee osteoarthritis. It aims to see which one works better for reducing pain and improving function, so you might experience less knee pain and better mobility.
TaipeiAges 50–80 - NCT03484325Enrolling by invitation
Patient registry for joint replacement and related surgeries
This trial is a “registry,” meaning it collects information from people who choose certain elective joint surgeries. It may help doctors better understand outcomes and safety after procedures like hip and knee operations.
Houston, TexasAges 18–100 - NCT05147675RecruitingPhase 1
Testing cord stem cell treatment for osteoarthritis safety
This early study (Phase 1) checks whether an infused stem cell product made from donated umbilical cord tissue is safe in people with osteoarthritis. It’s mainly looking for side effects and whether the treatment can be given safely.
Naples, FloridaAges Any age - NCT07104279Recruiting
Zimmer Biomet hip implant follow-up study
This study is for people who need a hip replacement for the first time. It is testing a specific hip implant system called the Z1 Hip System and will follow patients to see how well it works over time.
Platte City, MissouriAges 18 years+ - NCT02511158Recruiting
Knee ligament surgery study after ACL reconstruction
This study follows people who have a knee ligament tear and undergo surgery to rebuild the ligament. It may help doctors better understand recovery and outcomes after different surgical techniques.
ParisAges 7 years+
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Common questions
- Are there clinical trials for osteoarthritis?
- Yes. Clin2 currently lists 592 recruiting osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.