Clinical trials
Osteoarthritis clinical trials
Below are recruiting osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 592 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06485843RecruitingPhase 2
Testing a new injection for moderate to severe knee osteoarthritis
This study tests the safety of an experimental injection called OA-SYS for people with moderate to severe knee osteoarthritis. It may help if you have not had recent injections or certain other health problems.
Las Vegas, NevadaAges 35–75 - NCT06478186RecruitingPhase 4
Knee Osteoarthritis Steroid Injection Study for People with Type 2 Diabetes
This study compares two different steroid knee injections—Zilretta and Kenalog—to see which works better for people with both knee osteoarthritis and type 2 diabetes. It uses a continuous glucose monitor to track blood sugar changes.
Kansas City, KansasAges 40 years+ - NCT06466850Recruiting
Stem cell exosomes for knee osteoarthritis
This trial studies whether a natural substance called exosomes, derived from stem cells, can help reduce pain and improve function in people with knee osteoarthritis. It may be an option if other treatments have not worked well for you.
IsfahanAges 45–75 - NCT06430918Enrolling by invitation
Nerve pain and sleep quality in knee osteoarthritis
This study looks at how nerve pain and sleep quality are related in people with knee osteoarthritis. It aims to help doctors better understand and treat pain.
IzmirAges 18–80 - NCT06401317RecruitingPhase 2
Steroid vs saline injections for thumb arthritis pain
This study compares two types of injections for thumb arthritis pain: a steroid (cortisone) and salt water (saline). We want to see if the steroid provides better pain relief than the salt water.
Montreal, QuebecAges 18 years+ - NCT06414473RecruitingPhase 1/Phase 2
CBD for knee osteoarthritis pain
This study tests whether a CBD (cannabidiol) product can help reduce pain and improve daily life for people with knee osteoarthritis. If you have moderate to severe knee pain and haven't used cannabis recently, you may be able to join.
Gainesville, FloridaAges 40–75 - NCT06391554Recruiting
Education and exercise for hip osteoarthritis
This study compares the effects of adding exercise to an education program for people with hip osteoarthritis. It aims to see if exercise improves pain, function, and hip joint health (measured by MRI) more than education alone.
Aarhus CAges 45 years+ - NCT06384898Recruiting
Remote tai chi for knee osteoarthritis
This study tests whether doing tai chi remotely, twice a week for 12 weeks, helps reduce knee pain and improve function compared to routine care. Tai chi is a gentle exercise that may ease arthritis symptoms and can be done from home.
Boston, MassachusettsAges 50–100 - NCT05497349Recruiting
PRP injections for one-sided hip osteoarthritis
This study compares two types of PRP (platelet-rich plasma)—with white blood cells or without—for pain from one-sided hip osteoarthritis. It may help you see which injection type works better and is safe for improving hip symptoms.
BolognaAges 35–70 - NCT06281184Enrolling by invitation
Long-term follow-up of methotrexate for hand osteoarthritis
This study follows up on people who took part in the MERINO trial to see if methotrexate has lasting benefits for hand osteoarthritis. It aims to understand how the drug affects pain and joint health over 30 months.
OsloAges 18 years+ - NCT05926622Recruiting
Testing a Medacta shoulder replacement system for pain relief
This trial studies how well a Medacta shoulder replacement works by looking at clinical results and X-ray/scan findings after surgery. It may help people with certain shoulder conditions who need shoulder replacement or revision surgery.
AnnecyAges 18 years+ - NCT03650673Recruiting
Study of early finger osteoarthritis symptoms over time
This study follows people with early finger (hand) osteoarthritis symptoms to better understand how the condition starts and changes. You may be asked for blood tests, symptom checks, and imaging to see what’s happening in the joints.
MontpellierAges 18–60 - NCT06251167Recruiting
Shoe insoles for knee osteoarthritis
This study tests whether shoe insoles can help people with knee osteoarthritis. You might be eligible if you have had knee pain for at least 6 months, your pain is at least moderate, and you also have pain in the same foot.
Vancouver, British ColumbiaAges 50 years+ - NCT06245109RecruitingPhase 4
Pain medicine study for knee osteoarthritis
This study tests how well different pain medicines work for knee osteoarthritis and looks at brain patterns to understand why some people get more relief. It may help you find a treatment that works best for you.
Chicago, IllinoisAges 41 years+ - NCT06211387Enrolling by invitation
Stretching plus resistance exercise for knee osteoarthritis
This study tests whether adding a gentle stretching technique to resistance exercises helps reduce knee pain and improve movement in people with knee osteoarthritis. It may be a good option if you have mild-to-moderate knee arthritis and want to strengthen your knees without surgery.
Islamabad, FederalAges 40–65 - NCT06228573Recruiting
Brain stimulation and yoga for knee pain
This study combines a gentle brain stimulation technique (tDCS) with yoga to see if it helps reduce knee pain and improve movement in people with knee osteoarthritis.
Hamilton, OntarioAges 45 years+ - NCT06208631Recruiting
Movement retraining for knee osteoarthritis pain
This study tests a movement retraining program to see if changing how you walk can reduce stress on your knee and ease osteoarthritis pain. It’s a good fit for people with mild knee pain who want a non-surgical option.
Stanford, CaliforniaAges 18 years+ - NCT06163573RecruitingPhase 2
Engineered cartilage for kneecap arthritis
This trial tests a new way to treat arthritis in the kneecap area using specially grown cartilage. If you have kneecap pain and haven't been helped by other treatments, this might be an option to discuss with your doctor.
ZagrebAges 18–65 - NCT06151834Recruiting
Finger joint fusion study using KeriFuse implant
This trial tests a small metal implant (KeriFuse) that fuses the arthritic joint at the tip of your finger to reduce pain. It's for people with finger arthritis who are healthy enough for surgery.
NiceAges 18 years+ - NCT06145516Recruiting
Sleep program to ease pain after joint replacement
This study tests whether a sleep program can help with pain after knee or hip replacement. If you have insomnia and arthritis pain, you may be able to join before your surgery.
Uppsala, UpplandAges 18–100 - NCT02844751RecruitingPhase 2
Regenerative knee cell therapy for arthritis pain and swelling
This Phase 2 study tests a patient’s own (autologous) regenerative cell treatment to reduce knee pain and inflammation from osteoarthritis. It mainly looks at whether the treatment is safe and whether it can improve symptoms over time.
Grove City, PennsylvaniaAges 18–90 - NCT02844764RecruitingPhase 2
Cell therapy test for hip osteoarthritis pain and swelling
This trial tests an “autologous” regenerative cell treatment, meaning cells taken from you, to reduce hip osteoarthritis pain and inflammation. It checks safety first and looks for improvements in how you feel and move.
Grove City, PennsylvaniaAges 18–90 - NCT02844738RecruitingPhase 2
Cell therapy for shoulder osteoarthritis pain and inflammation
This trial tests a treatment using your own (autologous) regenerative cells to reduce pain and inflammation from shoulder osteoarthritis. It may help people with long-lasting shoulder pain, but you must meet several health and medication timing requirements.
Grove City, PennsylvaniaAges 18–90 - NCT06082531Recruiting
Platelet-rich plasma injection for knee osteoarthritis
This study tests whether injecting platelet-rich plasma (PRP) from your own blood can help knee pain caused by osteoarthritis or injuries to the cartilage and meniscus. It may be an option if you are between 20 and 60 years old and have not had recent steroid shots or certain health problems.
Xi'an, ShannxiAges 20–60
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Common questions
- Are there clinical trials for osteoarthritis?
- Yes. Clin2 currently lists 592 recruiting osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.