Clinical trials
Osteoarthritis clinical trials
Below are recruiting osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 610 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05842538Recruiting
Robotic surgery for total knee replacement in arthritis
This trial studies whether robotic-assisted surgery can improve or standardize outcomes for people getting a total knee replacement for severe arthritis. It may help by using a robot to assist during the knee operation, but you must meet specific knee and health criteria.
GothenburgAges 18–80 - NCT05868330RecruitingPhase 4
Compare two nerve-block methods for shoulder replacement
This trial compares two different ways of giving numbing medicine around the shoulder nerve before reverse shoulder replacement surgery. It may help find which method works better for pain control and comfort after surgery.
Iowa City, IowaAges 18–90 - NCT05892133Recruiting
Exercise program before knee replacement to improve recovery
This trial studies whether doing a structured exercise or “prehab” program before total knee replacement can improve knee function and patient satisfaction after surgery. It may help you recover better and feel more confident in your outcome.
Molde, Møre og RomsdalAges 50–80 - NCT05936814Recruiting
Study measures knee alignment in severe varus osteoarthritis
This study focuses on people age 65+ with severe “varus” knee alignment osteoarthritis (wear-and-tear arthritis that affects how the knee lines up). It aims to use your knee measurements and data to better understand the condition and guide care.
AnkaraAges 65 years+ - NCT05980442Recruiting
Navigation vs robotic-arm assisted knee replacement
This study compares two different high-tech tools used during total knee replacement surgery: one that uses a navigation system (OrthoPilot) and one that uses a robotic arm (MAKO). The goal is to see if one method leads to better results. If you're having a total knee replacement, this trial could help your surgeon choose the best approach.
Ulm, Baden-WurttembergAges 18–90 - NCT05985785Recruiting
Bone Marrow vs Steroid Injection for Knee Arthritis
This study compares two different knee injections—one using your own concentrated bone marrow cells (BMAC) and the other using a steroid (cortisone)—to see which works better for long-term knee pain from osteoarthritis.
Chicago, IllinoisAges 18–70 - NCT05986292RecruitingPhase 2
Study of new treatments for chronic pain
This study tests new treatments for chronic pain that lasts at least 3 months. Participants must stop their regular pain medicines and use only a rescue painkiller if needed. The goal is to find better ways to manage long-term pain.
Birmingham, AlabamaAges 18 years+ - NCT06010979Recruiting
Knee replacement with digital help study
This study looks at knee replacement surgery done with digital tools like robots or computer guidance. It may help people with knee arthritis find better ways to have surgery and recover.
Beijing, Beijing MunicipalityAges Any age - NCT06040827Recruiting
Study of a knee implant extension for knee replacement
This trial is for adults having their first knee replacement surgery. It tests a special part (tibial extension) of a common knee implant system. Researchers will follow participants over time to see how well it works.
Fayetteville, ArkansasAges 18 years+ - NCT06073106Recruiting
Frailty prevention study for older Asian adults
This trial tests a program to prevent frailty in people aged 50 and older of Asian descent who have recently been diagnosed with a stroke, traumatic brain injury, knee osteoarthritis, or breast cancer. The goal is to help you stay strong and healthy as you recover.
Singapore, SingaporeAges 50 years+ - NCT06075004Recruiting
Hip pain relief study comparing two injection methods
This trial tests two ways to give pain medicine around the hip joint during surgery to see which provides better pain relief. It may help patients experience less pain after hip replacement.
Santiago, Santiago MetropolitanAges 18–80 - NCT06077942Recruiting
FX shoulder replacement study
This study looks at how well FX shoulder replacement devices work for people who received them between 2018 and 2023. It helps doctors learn more about the outcomes of these implants.
Gilbert, ArizonaAges Any age - NCT06078865Recruiting
FX Shoulder Replacement Study
This study follows people who receive an FX shoulder replacement device to see how it works over time. It may be a good fit if you are planning this specific surgery with your doctor.
Gilbert, ArizonaAges Any age - NCT06083480RecruitingPhase 4
Reducing stress to prevent long-term pain after knee replacement
This trial tests if lowering oxidative stress (damage from natural body processes) during knee replacement surgery can prevent chronic pain afterward. It may help people with osteoarthritis who have moderate to severe pain before surgery.
Nashville, TennesseeAges 50 years+ - NCT06088160Recruiting
Balance changes after hip replacement for arthritis
This study looks at how your balance changes after a hip replacement for arthritis. You will have your balance tested before and after surgery to help doctors understand recovery.
London, OntarioAges 60 years+ - NCT06090097Recruiting
Game therapy for knee osteoarthritis
This trial tests a game-based therapy that uses biofeedback to help strengthen your knee. It may help you move better and feel less pain.
Chapel Hill, North CarolinaAges 30–75 - NCT06108934Recruiting
Study of the Insignia Hip Stem for First Hip Replacement
This study tests a new cementless hip stem (Insignia) for people having their first total hip replacement. It aims to see how long the implant lasts and how well your hip works after surgery.
Subiaco, Western AustraliaAges 18 years+ - NCT06122727Recruiting
Custom vs standard knee replacement for better fit
This trial compares custom-made knee replacements (built to fit your unique knee shape) with standard, off-the-shelf knee replacements. It aims to see if a custom implant leads to better function and satisfaction after surgery.
BolognaAges 40–70 - NCT06127719Recruiting
Surgery wait time and knee replacement quality of life
This study looks at how waiting for knee replacement surgery affects your quality of life. It may help doctors understand how to improve care for people waiting for surgery.
Hoorn, North HollandAges 18–100 - NCT06129214Recruiting
Partial tendon cleaning to reduce knee clicking after replacement
This trial studies a partial cleaning procedure on the quadriceps tendon during knee replacement to reduce clicking or rubbing sensation (crepitus). It is only for people getting a specific type of knee implant (posterior-stabilized) and whose kneecap is not replaced.
Seoul, GangnamGuAges 19 years+ - NCT06136039Recruiting
Muscle loss and knee replacement recovery in older women
This study looks at how muscle loss (sarcopenia) affects recovery after total knee replacement in older women. If you join, you'll have some simple walking and strength tests to see how your muscles impact your surgical outcome.
SeoulAges 60 years+ - NCT06158646Recruiting
Comparing knee replacement alignment methods
This study compares two ways to align a total knee replacement (mechanically vs. kinematically) to see which leads to better function one year after surgery. If you've had a knee replacement a year ago and are generally healthy enough to walk without major issues from other leg joints or nervous system problems, you might be eligible.
MérignacAges 18 years+ - NCT06167928Recruiting
Developing new treatments from donated tissue
This study collects tissue from children having surgery for polydactyly or hip dislocation, so researchers can develop new treatments for muscle and bone problems.
Oswestry, ShropshrieAges Any age - NCT06173713Recruiting
Hip replacement study with precise X-ray tracking
This trial tests a new way of tracking how well hip replacements settle in over time using special X-ray images. It is for adults who need a first-time total hip replacement due to conditions like arthritis, injury, or hip deformity.
Winnipeg, ManitobaAges 21 years+
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Common questions
- Are there clinical trials for osteoarthritis?
- Yes. Clin2 currently lists 610 recruiting osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.