Clinical trials
Osteonecrosis clinical trials
Below are recruiting osteonecrosis clinical trials, each written for real people, not researchers. We’re tracking 18 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06457776Recruiting
Jaw bone health in people taking bone-strengthening drugs
This study looks at how a specific jaw problem (osteonecrosis) may happen in people taking bone-strengthening medications. It aims to better understand and manage this side effect.
RomaAges 18 years+ - NCT07177378Enrolling by invitation
Double flap closure for jaw bone damage from medication
This trial tests a surgical technique using a double tissue flap to close the jawbone in patients with medication-related osteonecrosis of the jaw (MRONJ). The goal is to improve healing and reduce complications.
TantaAges Any age - NCT05664815RecruitingPhase 2
Amniotic membrane treatment for advanced jaw bone loss
This Phase 2 trial studies whether a human amniotic membrane dressing can help heal stage II maxillomandibular osteonecrosis of the jaw (MRONJ). It focuses on people who developed MRONJ after certain cancer-related bone treatments and who may need surgery and antibiotics.
BesançonAges 18 years+ - NCT05795647RecruitingPhase 2
Testing pentoxifylline and vitamin E for jaw bone damage
This trial tests a combination of medicines (pentoxifylline and tocopherol, a form of vitamin E) to treat damage to the jaw bone caused by bone-strengthening drugs. If you have Stage 2 MRONJ and meet other criteria, this treatment may help heal the bone.
LimogesAges 18 years+ - NCT05329558Enrolling by invitation
Testing changes in jawbone problems in adults
This study looks at what changes happen in the jawbone in people with osteonecrosis of the jaw (a damaged jawbone area), whether or not they take certain cancer/bone medicines. It may help doctors better understand the condition and how it behaves over time.
GrazAges 18 years+ - NCT06016634RecruitingPhase 2
Alendronate for bone damage in adults with sickle cell disease
This trial tests if the drug alendronate can help heal bone damage caused by sickle cell disease. It may be an option if you have this bone problem and are between 18 and 80 years old.
Sacramento, CaliforniaAges 18–80 - NCT06123481Recruiting
Bone marrow treatment for early hip bone loss
This trial tests whether injecting your own bone marrow into the hip can help heal early-stage osteonecrosis (bone death) before the bone collapses. It is for people who have not had prior hip surgery and do not have certain conditions like sickle cell disease.
Los Angeles, CaliforniaAges 18–90 - NCT07545616Recruiting
Finding biomarkers for femoral head bone death
This study looks for biological signs (biomarkers) that can help identify and understand osteonecrosis of the femoral head—a condition where bone in the hip dies. Researchers hope these signs will improve how doctors diagnose and treat the condition.
Xinxiang, HenanAges 18–70 - NCT07435259Recruiting
Treating jaw bone problems around dental implants: keep or remove?
This study compares two ways to treat a jaw bone problem caused by medications (called MRONJ) when it happens around a dental implant. One option is to keep the implant and treat the bone, the other is to remove the implant. The goal is to see which approach leads to better healing.
Seoul, SeoulAges 20 years+ - NCT04098146Recruiting
Registry for jawbone reconstruction after jaw cancer and jaw bone death
This study collects real-world information from people undergoing jaw reconstruction after their jaw bone was damaged (from cancer and certain medicines). It may help improve future treatment planning by tracking surgical choices and outcomes.
Jacksonville, FloridaAges 18 years+ - NCT04007783Recruiting
Test of a new plan for jaw reconstruction and implants
This study checks whether the “O-bridge protocol” helps people who need jaw surgery—either for osteonecrosis of the jaw or for oral/jaw tumors—followed by dental implant placement to support fixed teeth (not removable dentures). The goal is to improve your ability to eat, speak, and get a stable tooth replacement plan after surgery.
AntwerpAges 18 years+ - NCT06430762Recruiting
Study of risk factors for jaw bone damage from certain drugs
This study looks at people who have jaw bone damage (osteonecrosis) caused by medications. Researchers want to understand what treatments and risk factors are linked to this condition to help improve care.
IstanbulAges 18–110 - NCT05603728Recruiting
Follow-up study for Exactech shoulder implants after surgery
This study follows people who get (or already had) a shoulder replacement to see how the implant is doing over time. It may help improve future care by tracking long-term performance and safety.
Laguna Woods, CaliforniaAges 21 years+ - NCT05734651Recruiting
Study of PROMIS stem in hip replacement patients
This study looks at people who had a hip replacement (total hip arthroplasty) using the PROMIS stem. The goal is to evaluate how this specific hip part performs in real-world use.
Sankt Johann in Tirol, TyrolAges 18 years+ - NCT06129214Recruiting
Partial tendon cleaning to reduce knee clicking after replacement
This trial studies a partial cleaning procedure on the quadriceps tendon during knee replacement to reduce clicking or rubbing sensation (crepitus). It is only for people getting a specific type of knee implant (posterior-stabilized) and whose kneecap is not replaced.
Seoul, GangnamGuAges 19 years+ - NCT06823089Recruiting
Study of a new hip implant for cartilage repair
This trial tests a new implant called ReNew Hip Implant to repair damaged cartilage in the hip joint. It may be an option if you have hip pain that hasn't improved with other treatments like physical therapy or injections.
St Louis, MissouriAges 14–64 - NCT02661139Recruiting
Registry of jaw reconstruction for cancer patients who need implants
This study is a “real-world” registry that follows people with jaw problems related to cancer or cancer treatment. It looks at how well jaw reconstruction with dental implants and fixed teeth works when removable dentures are not suitable.
BrugesAges Any age - NCT07255768Enrolling by invitation
Pain relief blocks for hip surgery: comparing two methods
This study compares two types of nerve blocks to see which provides better pain relief after hip surgery. One block targets the capsule around the hip joint, while the other adds blocks for nearby nerves. The goal is to find a more effective way to manage pain.
ErzurumAges 18–80
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Common questions
- Are there clinical trials for osteonecrosis?
- Yes. Clin2 currently lists 18 recruiting osteonecrosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteonecrosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteonecrosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.