Clinical trials
Ovarian Cancer Stage IV clinical trials
Below are recruiting ovarian cancer stage iv clinical trials, each written for real people, not researchers. We’re tracking 168 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT01000259Recruiting
Using stored tumor tissue after surgery for advanced ovarian cancer
This study looks at archived tumor tissue samples from people with advanced (stage III or IV) ovarian epithelial cancer who had surgery and standard “platinum/taxol” chemotherapy trials. It may help researchers understand the cancer better and improve future treatments.
Philadelphia, PennsylvaniaAges Any age - NCT03025477RecruitingPhase 2
Testing two first-treatment options for advanced ovarian cancer
This Phase 2 trial compares two different treatment strategies as the first chemotherapy after surgery for advanced epithelial ovarian, peritoneal, or fallopian-tube cancer. It may help doctors find a more effective or better-tolerated approach for people in your situation.
DijonAges 18–75 - NCT03787056Recruiting
Blood test marker study in many cancer types
This study measures a blood marker called progastrin (at diagnosis and during treatment) to see how well it predicts response or outcomes. It may help doctors choose or monitor treatment more precisely for several cancer types.
BronAges 18 years+ - NCT05733000RecruitingPhase 2
CPI-613 plus hydroxychloroquine with chemo for advanced solid tumors
This trial tests a drug called CPI-613 (devimistat) combined with hydroxychloroquine along with either 5-fluorouracil or gemcitabine chemo. It’s for people with advanced cancers that have stopped responding to standard treatments, aiming to shrink tumors and slow cancer growth.
Chicago, IllinoisAges 18 years+ - NCT03275194RecruitingPhase 2
HIPEC during interval surgery for advanced ovarian cancer
This trial looks at whether a heated chemotherapy treatment given in the abdomen during a planned second surgery (HIPEC) can improve outcomes for certain advanced ovarian cancers. It is for people who have already had initial chemotherapy and partially responded, with enough health to safely undergo surgery.
Mexico CityAges 18–70 - NCT05862740Recruiting
Surgery study for advanced ovarian cancer after chemotherapy
This study looks at how well a minimally invasive surgery (laparoscopic debulking) can remove tumor in people with advanced epithelial ovarian cancer. It may help doctors compare whether this approach is safe and effective for patients who need either upfront surgery or surgery after chemotherapy.
Padova, Padova, VenetoAges 18 years+ - NCT06028724Recruiting
Looking for cancer mutations using a blood test
This study uses a blood test (liquid biopsy) to find genetic changes in advanced solid tumors. It may help doctors choose the right treatment and monitor how well it works over time.
Aviano, PordononeAges 18 years+ - NCT06032975Recruiting
Fighting fatigue with a patient-reported tool in ovarian cancer
This trial tests whether using a patient-reported outcomes tool can help manage fatigue during treatment for ovarian cancer. It aims to improve how you feel during therapy.
NaplesAges Any age - NCT05961124RecruitingPhase 2
Lower-dose niraparib to reduce interruptions in ovarian maintenance
This trial tests whether a different starting dose (and adjustments) of niraparib can help people with advanced ovarian (or related) cancer stay on treatment without as many dose interruptions. It’s designed for people who have already finished first-line chemotherapy and whose cancer responded.
Toronto, OntarioAges 18 years+ - NCT06215950RecruitingPhase 1
CAR-T cell therapy for advanced gynecologic cancer with CD70 protein
This trial tests a new treatment called CAR-T cells that target a protein called CD70 found on some gynecologic cancer cells. It is for people whose cancer has advanced or spread and has not responded to or stopped responding to standard treatments.
Wuhu, AnhuiAges 18 years+ - NCT05652283RecruitingPhase 2
Combination treatment before surgery for advanced ovarian cancer
This trial tests two oral medications, pamiparib and surufatinib, given before surgery to shrink advanced ovarian cancer. The goal is to make surgery more successful and potentially improve outcomes for patients who cannot have surgery right away.
Hefei, AnhuiAges 18 years+ - NCT06272240Recruiting
Tumor environment study in advanced ovarian cancer
This study looks at the environment around ovarian cancer tumors to better understand the disease. It might help researchers find new ways to treat patients with advanced ovarian cancer.
Udine, UDAges 18–80 - NCT06307249RecruitingPhase 1
Precision therapy for solid tumors targeting CDK4/6 and VEGF
This trial tests a combination of two targeted drugs for advanced solid tumors like colorectal, lung, breast, and genitourinary cancers. The goal is to see if blocking certain proteins and a long RNA molecule can slow tumor growth.
Tripoli, North LebanonAges 18 years+ - NCT06395844RecruitingPhase 1/Phase 2
NK cell therapy for advanced ovarian cancer
This trial tests a new therapy that uses your own natural killer (NK) cells, modified to better fight cancer and injected directly into your abdomen. It's for people with advanced ovarian cancer who cannot have surgery or whose tumor cannot be fully removed.
Hefei, AnhuiAges 18–70 - NCT05410717RecruitingPhase 1
CAR-NK cell therapy for certain solid tumors
This early-phase trial tests a lab-made immune cell treatment for advanced solid tumors that show specific targets (including Claudin 6, GPC3, Mesothelin, or AXL). It may help the immune system better recognize and kill tumor cells, but eligibility depends on test results and your overall health.
Guangzhou, GuangdongAges 18–75 - NCT07776691RecruitingPhase 3
Study of Raludotatug Deruxtecan for Advanced Ovarian Cancer
This study tests a new drug (raludotatug deruxtecan) with or without another drug (bevacizumab) as maintenance therapy after initial chemotherapy for advanced ovarian cancer. It aims to see if this combination can help keep the cancer from coming back.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07741968Recruiting
Online program to ease fear of cancer returning
This study tests an online program designed to help women with advanced or certain types of breast or gynecologic cancer manage their fear of the disease progressing or returning. The program aims to reduce anxiety and improve quality of life.
Arcadia, CaliforniaAges 18 years+ - NCT07733505RecruitingPhase 1
Heated chemotherapy for older women with advanced ovarian cancer
This trial tests a new way to give heated chemotherapy directly into the abdomen during surgery for women aged 70 and older with advanced ovarian cancer. It aims to find a gentler treatment option that may still be effective for those who are more frail.
OdenseAges 70 years+ - NCT07665515RecruitingPhase 1
Testing a cancer vaccine in maintenance for advanced ovarian cancer
This trial tests a vaccine called CryptiVax-1001 for people with advanced ovarian cancer who have finished first-line chemotherapy and are in remission, as maintenance therapy. The goal is to see if the vaccine can help keep the cancer from coming back.
CambridgeAges 18 years+ - NCT07636200Recruiting
Managing Fear and Worry in Advanced Cancer
This study tests a new approach to help people with advanced cancer who feel significant fear about their cancer getting worse or coming back. The program uses writing and therapeutic techniques to help reduce this fear and related stress.
Aurora, ColoradoAges 18 years+ - NCT05927818Recruiting
Test a sentinel lymph node biopsy in early ovarian cancer
This trial studies whether taking a sample from the sentinel lymph node during surgery can help with staging early ovarian cancer. It may help doctors find spread to lymph nodes more accurately while limiting unnecessary lymph node removal in some cases.
Istanbul, TurkeyAges 18–90 - NCT07612891RecruitingPhase 1/Phase 2
Testing INV-6452 for advanced breast cancer and solid tumors
This study tests a new drug called INV-6452 to see if it is safe and can help control advanced cancers that have grown despite prior treatment. The drug targets specific cancer cell weaknesses, particularly in hormone-sensitive breast cancers without HER2 mutations.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06437353RecruitingPhase 2
Surufatinib combo for first-line and maintenance in high-risk ovarian cancer
This trial tests a combination of drugs (Surufatinib with carboplatin/paclitaxel) as first treatment for high-risk ovarian cancer, followed by a different combination (Surufatinib with olaparib) to keep the cancer from coming back. It aims to see if these targeted therapies work better than the standard approach.
Hefei, AnhuiAges 18–75 - NCT06735326RecruitingPhase 2
Fluzoparib and Bevacizumab Before Surgery for Advanced Ovarian Cancer
This trial tests whether combining fluzoparib (a PARP inhibitor) with or without bevacizumab (a blood vessel growth blocker) before surgery can shrink advanced ovarian cancer. It is for women with a BRCA gene mutation whose cancer cannot be fully removed with surgery right now.
Jinan, ShandongAges 18 years+
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Ovarian Cancer Stage IV trials by city
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Ovarian Cancer Stage IV trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for ovarian cancer stage iv?
- Yes. Clin2 currently lists 168 recruiting ovarian cancer stage iv studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a ovarian cancer stage iv trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a ovarian cancer stage iv trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.