Clinical trials
Overdose clinical trials
Below are recruiting overdose clinical trials, each written for real people, not researchers. We’re tracking 31 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07079241Recruiting
Volunteer naloxone responders for opioid overdose emergencies
This trial trains volunteers to give naloxone, a medication that reverses opioid overdoses, using a smartphone app to alert nearby responders. It could help save lives by getting antidote treatment to overdose victims faster.
Malmö, Skåne CountyAges 18 years+ - NCT07179614Recruiting
Kentucky women's overdose recovery program
This trial tests a support program for women in Kentucky jails who have opioid or stimulant use disorder. It aims to reduce overdose risk after release by connecting them with community support.
Barbourville, KentuckyAges 18 years+ - NCT06327061Recruiting
Opioid overdose prevention with friends and family
This trial tests a program where people who use opioids learn to educate their friends and family about overdose prevention. It may help build a safer support network in Baltimore.
Baltimore, MarylandAges 18 years+ - NCT05320835Recruiting
Talk-based overdose prevention for people using opioids
This trial tests an overdose prevention approach for people who have used opioids recently. It aims to help reduce the risk of overdose by offering a structured prevention intervention.
Baltimore, MarylandAges 18 years+ - NCT07485335RecruitingPhase 4
Overdose prevention support after emergency department care
This study tests a package of support services to help people who have had an opioid overdose and are starting buprenorphine in the emergency department. The goal is to keep them safe and reduce the chance of another overdose.
Birmingham, AlabamaAges 19 years+ - NCT07219082Recruiting
Fentanyl safety education for people who use stimulants
This study is testing a program called BSAFE that teaches people who use stimulants like cocaine or methamphetamine how to stay safer around fentanyl. It aims to prevent accidental fentanyl exposure and its harms.
San Francisco, CaliforniaAges 18 years+ - NCT07193069Recruiting
Metformin overdose in the ICU – signs and dapagliflozin effects
This study looks at patients who are in the ICU after taking too much metformin (a diabetes drug), sometimes along with another drug called dapagliflozin (Farxiga). The goal is to understand how overdose affects the body and what signs doctors should watch for.
Saint-Denis, FranceAges 18 years+ - NCT06823453Recruiting
Training friends and family to support people who use opioids
This study trains friends and family members of people who use opioids, so they can provide better support and reduce stigma. It also includes people who use opioids to see if this training improves their relationship and well-being.
Chicago, IllinoisAges 18 years+ - NCT06633900RecruitingPhase 2/Phase 3
Testing naltrexone to prevent overdose in stimulant users
This trial tests whether naltrexone, a medication that blocks the effects of opioids, can help prevent overdose in people who use stimulants like cocaine or methamphetamine. It may be a good fit if you are at risk for HIV or living with HIV, and have a stimulant use disorder or use stimulants at least 10 days per month.
San Francisco, CaliforniaAges 18 years+ - NCT06466005Recruiting
Phone app to help reverse overdoses in Philadelphia
This trial tests a smartphone app that helps people quickly reverse an opioid overdose. If you live or work in certain Philadelphia neighborhoods, the app may help you save a life.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06084221Enrolling by invitation
Studying overdose review teams to improve surveillance
This study looks at how local overdose fatality review (OFR) teams work and how they can help track and prevent overdoses better. Researchers will also use anonymous administrative data to understand overdose patterns in Indiana. The goal is to make our surveillance systems stronger and save lives.
Indianapolis, IndianaAges Any age - NCT07649278Recruiting
ENHANCE project toolkit for safer drug use
This study is building a toolkit to improve harm reduction services for people who use drugs. You may be able to join if you've used certain drugs recently and feel you need more support.
Madison, WisconsinAges 18 years+ - NCT05557448RecruitingPhase 2
N-Acetylcysteine treatment for serious acetaminophen overdose
This Phase 2 trial studies whether TYNADOTE® can treat people who have taken a harmful acetaminophen (Tylenol) overdose while checking safety. It may be considered if your overdose is high enough to put you at risk for liver injury and you can follow the treatment and follow-up visits.
Taipei, Beitou DistrictAges 20 years+ - NCT05599438Recruiting
Fitness and drug use study in recreational athletes
This study follows recreational athletes to understand how past and current anabolic-androgenic steroid (AAS) use relates to fitness changes over time. If you have used these substances in the past (and stopped more than 3 months ago), or you have never used them, you may be able to join.
CopenhagenAges 18 years+ - NCT07631598Recruiting
Buprenorphine at Needle Exchange Programs to Prevent Overdoses
This study tests whether offering buprenorphine (a medication that reduces cravings and withdrawal) directly at syringe service programs (places where people get clean needles) can help people with opioid addiction stay safe and reduce overdose risk. If you use opioids and visit a syringe service program, this may be an option to explore.
Los Angeles, CaliforniaAges 18 years+ - NCT05665179Recruiting
Community program for people receiving addiction treatment
This trial is focused on people who are currently getting treatment for substance use disorder. It aims to test community partnership approaches that reduce barriers and improve support during recovery.
Ann Arbor, MichiganAges 18 years+ - NCT07527871Enrolling by invitation
Emergency care screening and counseling for substance use prevention
This study tests whether screening patients in the emergency department for substance use, followed by a brief counseling session, can help prevent substance use problems and overdoses. You would be asked about your substance use and receive supportive counseling by phone or video.
Columbus, OhioAges 18 years+ - NCT07524972RecruitingPhase 3
Magnesium sulphate to protect babies born very early
This study tests whether giving magnesium sulphate (a mineral treatment) to pregnant women at risk of delivering very early (32–35 weeks) can protect the baby's brain and nervous system. The treatment is given before labor starts.
Ismailia, Ismailia GovernorateAges 18–45 - NCT07459166RecruitingPhase 2
Testing a new drug for fentanyl overdose
This study tests a new drug, CS-1103, to see if it can safely help reverse the effects of fentanyl (a strong opioid) even after a naloxone block. Healthy volunteers who have used opioids before will be given fentanyl and then the study drug, while researchers monitor safety and how the drug works.
Glendale, CaliforniaAges 18–55 - NCT05981573Recruiting
Measuring methadone doses for chronic pain
This trial is for people with chronic pain who take daily methadone. It aims to measure how much methadone is in your body to help doctors find the right dose.
Lemon Grove, CaliforniaAges 18–70 - NCT07170072Recruiting
Shelter Harm Reduction Program Study
This study looks at a program called the Shelter Harm Reduction Program (HRSP) in New York City shelters. It aims to see if the program helps people who use drugs and stay in shelters. Researchers will interview people who have stayed in these shelters to learn about their experiences.
New York, New YorkAges 18 years+ - NCT06852170Recruiting
Data-driven decisions for substance use services
This trial helps decision-makers use data to improve substance use services and prevent overdoses. It is for professionals who shape policy or run programs in behavioral health, public health, law enforcement, or advocacy.
Eugene, OregonAges 18 years+ - NCT06854757Recruiting
Support after losing a loved one to overdose
This study is for people who lost a loved one to an unintentional drug overdose in the past year. It looks at how families are doing after such a loss and what kind of support might help.
Birmingham, AlabamaAges 18 years+ - NCT06768814Recruiting
Overdose recovery and care access study
This study looks at how people recover from an overdose and get connected to care. It interviews people who have had an overdose to understand their experience and improve access to follow-up services.
Seattle, WashingtonAges 18 years+
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Overdose trials by city
Studies with a site in or near these metro areas.
Overdose trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for overdose?
- Yes. Clin2 currently lists 31 recruiting overdose studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a overdose trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a overdose trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.