Clinical trials
Pathogenesis clinical trials
Below are recruiting pathogenesis clinical trials, each written for real people, not researchers. We’re tracking 46 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06093204Recruiting
Ultra-processed foods and eosinophilic esophagitis study
This study looks at how certain chemicals from ultra-processed foods (like packaged snacks and sodas) might trigger eosinophilic esophagitis, a food allergy condition. It will compare people with the disease to healthy volunteers of the same age and sex.
Naples, NaplesAges 3–65 - NCT05851209Recruiting
Study biomarkers in people with moderate aortic valve narrowing
This study looks at blood and/or body signals (called biomarkers) to understand why aortic valve narrowing may worsen and what outcomes people have. You may be able to help researchers by undergoing regular heart care plus additional testing like MRI or CT if you qualify.
BonnAges 18 years+ - NCT05703386Recruiting
Study MRI changes in small-vessel stroke disease
This study looks at how “small-vessel” changes in the brain develop after an ischemic stroke, using repeated MRI scans. It may help researchers better understand what causes these changes and how to track them over time.
Baltimore, MarylandAges 18 years+ - NCT05636748Recruiting
Study how blood clots affect stroke, using special scans
This study looks at how blood clots form and contribute to an acute ischemic (clot-related) stroke. It uses PET-CT scanning to better understand the process and may help improve how future stroke treatments are targeted.
EdinburghAges 18 years+ - NCT05550194RecruitingPhase 4
Study of an antiviral to treat achalasia-related nerve inflammation
This trial looks at whether the antiviral medicine valacyclovir, plus Shingrix vaccine, can change disease affecting the gut’s nerve system in people with achalasia. If you’re eligible, you would complete specific swallow and pressure tests and then take the medicines for about two months.
Nashville, TennesseeAges 18–75 - NCT05284006Recruiting
Non-invasive tests for Morquio A
This trial studies Morquio A (MPS IVA) using non-invasive ways to measure how the body is working, and to better understand why the condition happens. If you have Morquio A, this may help researchers learn more and improve care.
Wilmington, DelawareAges Any age - NCT05072483Recruiting
Study of CADASIL’s natural course using blood tests and MRI
This study follows people with CADASIL (a genetic brain blood-vessel condition) to learn how it progresses over time. It uses blood and possibly tissue samples and brain MRI scans to better understand changes in the brain.
Bethesda, MarylandAges 18–100 - NCT05026138Recruiting
Study of severe HPV disease and why it keeps coming back
This study follows people with severe or hard-to-treat HPV-related conditions (and some closely related partners/household contacts) to learn how the virus causes illness and how the immune system responds. It may help doctors better predict who will develop severe disease and guide future treatments.
Bethesda, MarylandAges 3–100 - NCT04634643Recruiting
Studies what causes fatty liver in teens
This study looks at why “nonalcoholic fatty liver disease” happens in teenagers and how it develops. It may help doctors better predict and prevent liver problems in children, even if there isn’t a new drug for you to take.
New Haven, ConnecticutAges 12–18 - NCT02821767Recruiting
Eye disease natural history study
This study observes people with various eye conditions to understand how they progress and to help improve future treatments. It may help you learn more about your condition and contribute to medical knowledge.
Bethesda, MarylandAges 2–100 - NCT02974595Recruiting
Study of rare inflammatory conditions to learn what causes them
This study follows people with rare “autoinflammatory” conditions and sometimes their blood relatives to understand why symptoms happen and how they change over time. It may help by improving diagnosis and care for these conditions, using stored samples and genetic testing.
Bethesda, MarylandAges Up to 99 years - NCT02257866Recruiting
Study of blood vessel inflammation over time
This study looks at different types of blood vessel inflammation (vasculitis) to learn more about why they happen and how they progress. By joining, you may help doctors better understand these conditions and improve future treatments.
Bethesda, MarylandAges 3 years+ - NCT02504879Recruiting
Study of melorheostosis progression and genetic causes
This study follows adults with suspected or confirmed melorheostosis to understand how the condition develops and what outcomes to expect. It may help researchers better understand the disease and its genetic factors.
Bethesda, MarylandAges 18–90 - NCT02190266Recruiting
Study genetics and cause of hard-to-treat Valley fever
This study looks at why “Valley fever” is difficult to treat or has spread beyond the lungs, and how a person’s genetics may be involved. You may be asked for blood or other samples for genetic testing and for storing samples for future research.
Bethesda, MarylandAges 2–100 - NCT01778543Recruiting
Study genes behind small eyes and eye coloboma
This study looks at how genes may cause certain eye conditions called microphthalmia, anophthalmia, and uveal coloboma. You may qualify if you have one of these conditions or are a close, unaffected relative who could also carry the gene.
Bethesda, MarylandAges 1–100 - NCT01728402Enrolling by invitation
Study of the causes of certain blood cancers
This study looks at what leads to specific blood cancers and related blood disorders. If you have one of the listed conditions (or are being evaluated for it), you may be asked to join research that helps doctors understand why these illnesses happen.
Portland, OregonAges 1 year+ - NCT00807482Recruiting
Study of lung disease causes in primary ciliary dyskinesia
This study looks at how primary ciliary dyskinesia (PCD—a lifelong problem with tiny lung “sweepers”) affects the lungs. You may be able to join if you strongly seem to have PCD based on symptoms, or if you’re a healthy person with a close family member who has confirmed PCD.
Chapel Hill, North CarolinaAges Any age - NCT01161199Recruiting
Leukapheresis study in people living with HIV
This trial uses a special blood-filtering procedure (leukapheresis) along with blood tests to better understand how HIV affects the body. It may help researchers learn more about HIV “pathogenesis,” which means what drives disease in different people.
San Francisco, CaliforniaAges 18 years+ - NCT00669266Recruiting
Study of adrenal tumors—causes and possible treatments
This study looks at adrenal tumors found on imaging (scans) to better understand what causes them and how they might be treated. If you have an adrenal tumor on a scan, this trial may be looking to enroll you for that purpose.
WürzburgAges Up to 100 years - NCT01202305Recruiting
Lymph node biopsies to study HIV in different patients
This study uses a small tissue sample from an often-accessible lymph node to learn how HIV affects the body. It may help researchers understand why some people control HIV better than others.
San Francisco, CaliforniaAges 18–70 - NCT00867269Recruiting
Study of causes and progression of low CD4 blood cells
This study looks for what causes and how idiopathic low CD4 cells happen over time, using blood and tissue samples. It may help doctors learn why this occurs and how to better track people with it.
Bethesda, MarylandAges 18 years+ - NCT00001281Recruiting
Understanding how HIV affects blood cells and body fluids
This research study examines how HIV works in the blood and body fluids of people with and without HIV. By studying blood samples, researchers hope to better understand HIV infection and develop better treatments.
Washington D.C., District of ColumbiaAges 18–120
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Common questions
- Are there clinical trials for pathogenesis?
- Yes. Clin2 currently lists 46 recruiting pathogenesis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pathogenesis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pathogenesis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.