Clinical trials
Periodontal Diseases clinical trials
Below are recruiting periodontal diseases clinical trials, each written for real people, not researchers. We’re tracking 108 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07069140Recruiting
Lactoferrin mouthwash for gum health during pregnancy
This study tests if a daily lactoferrin mouthwash can improve gum health in pregnant women with gum disease, without needing antibiotics or other treatments. Researchers want to see if this natural protein helps keep gums healthier during the second trimester.
Pavia, LombardyAges 18–45 - NCT07615361Enrolling by invitation
Tooth Graft and Laser Therapy for Dental Implants
This study tests whether material from extracted teeth, combined with low-level laser treatment, can help bone heal better before dental implants are placed. The goal is to improve implant success and reduce bone loss after tooth removal.
Istanbul, UskudarAges 18–65 - NCT04669717RecruitingPhase 4
Testing antibiotic dosing alongside periodontal treatment
This study tests how antibiotics should be added to standard gum (periodontal) treatment, including dosing and blood-level timing. It may help people whose gum disease is severe, by improving how antibiotics are used with routine dental care.
Geneva, Canton of GenevaAges 18–80 - NCT06110143Recruiting
Gum health and pregnancy complications study
This study looks at how gum disease (periodontitis) during pregnancy might affect pregnancy outcomes. It may help you if you have gum disease and want to learn more about its impact on your pregnancy.
Holbæk, HolbaekAges 16–48 - NCT06755372Recruiting
TLR-4 in gum disease patients with kidney failure
This study looks at a specific immune marker (TLR-4) in people with gum disease, comparing those who also have end-stage kidney disease (on dialysis) to those who are otherwise healthy. The goal is to understand how gum disease might be different when kidney failure is also present.
Al Fayyum, Faiyum GovernorateAges 30–60 - NCT07424846RecruitingPhase 2/Phase 3
Xylitol gum to prevent gum disease and early birth
This trial tests if chewing xylitol gum during pregnancy can reduce gum disease and preterm birth. You would chew gum after meals and attend dental visits and follow-ups.
LilongweAges Any age - NCT07296965Recruiting
Oral bacteria in carotid artery plaque study
This study looks at the bacteria living in your mouth and whether they are linked to plaque buildup in the carotid artery (the main artery in your neck). If you are already scheduled for surgery to remove that plaque, the researchers will take samples from your mouth and the plaque to compare them.
BudapestAges 18 years+ - NCT06373848Enrolling by invitation
Vitamin E and Coenzyme Q10 for early gum disease
This study tests whether adding vitamin E and coenzyme Q10 to standard gum treatment can help heal early-stage chronic gum disease. It is for otherwise healthy adults aged 28-35 with mild gum pockets on their lower molars.
TehranAges 28–40 - NCT07343804Recruiting
Dental root canal and heart disease risk study
This trial tests whether treating a tooth infection with a root canal can lower blood markers linked to heart risk in people with stable heart disease.
Rohtak, HaryanaAges 30 years+ - NCT06784817Recruiting
Gum health in smokers and heated tobacco users
This study compares gum health in three groups: daily cigarette smokers, exclusive users of heated tobacco products (like IQOS), and never-smokers. It aims to see if heated tobacco has different effects on gums compared to traditional smoking.
Budapest, Pest CountyAges 18 years+ - NCT07263113Recruiting
Gum disease and heart health study
This study looks at whether severe gum disease (periodontitis) is linked to stiffer arteries and higher heart risk. If you have advanced gum disease or healthy gums, you may be able to join to help researchers understand this connection.
NantesAges 40–69 - NCT06311253Enrolling by invitation
Gum treatment with lactoferrin toothpaste in pregnancy
This study tests whether special toothpaste and mouthwash with lactoferrin (a natural protein) can help treat gum problems in pregnant women. It may offer a safe way to care for your gums during pregnancy.
Pavia, LombardyAges 18–40 - NCT06308497Enrolling by invitation
Periodontal treatment with CoQ10 and probiotics for pregnant women
This study tests whether a combination of coenzyme Q10 and probiotics can improve gum health in pregnant women. It aims to find a safe, gentle treatment for gum problems during pregnancy.
Pavia, LombardyAges 18–40 - NCT07666126Recruiting
Uric acid and gum bone health study
This study looks at whether high uric acid levels affect the bone around your teeth. If you are between 18 and 65, have at least 20 natural teeth, and are either healthy or have high uric acid and gum disease, this trial may be for you.
RizeAges 18–65 - NCT07718061Recruiting
Bacteria in dental plaque with orthodontic retainers
This trial studies the types of bacteria found in dental plaque from people who have orthodontic retainers after braces. It aims to understand how retainers affect oral bacteria.
MurciaAges 18–40 - NCT06676826Recruiting
Comparing two gum-graft materials for bone defects
This study tests two types of gum-graft materials to see which works better for rebuilding bone next to deep pockets caused by gum disease. Both materials are used during a minor surgical procedure to help your gums and bone heal stronger.
BernAges 18 years+ - NCT07306026Recruiting
Testing a toothbrush's bristles on plaque and gums
This trial compares how well different toothbrush bristles remove plaque and affect gum health. It may help find the best toothbrush design for everyday oral care.
Buffalo, New YorkAges 18–70 - NCT07725913Recruiting
Gel for gum treatment after deep cleaning
This trial tests if a special gel placed in the gums after deep cleaning helps treat periodontitis (advanced gum disease). You may qualify if you have gum pockets of 5mm or deeper that bleed when probed.
Bologna, BOAges 18 years+ - NCT07688421Enrolling by invitation
Short 3D-printed implants for back jaw teeth: 3-year study
This trial tests shorter implants made with 3D-printing for replacing missing teeth in the back of the mouth. Researchers will check how well they work over 3 years using X-rays.
Guarulhos, São PauloAges 18 years+ - NCT04254861Recruiting
Platelet treatment for deep gum bone defects
This trial studies an “autologous platelet concentrate” (a gel made from your own blood) to help heal deep bone defects caused by periodontitis. It’s meant for adults with specific measurements in one or more gum pockets and bone areas after recent non-surgical gum treatment.
LondonAges 25–80 - NCT06315855Recruiting
Oral Health Program for Cancer Survivors
This study tests a program to help cancer survivors improve their oral health using a smartphone app. It's for survivors who are at least 6 months past treatment and have not had head, neck, or mouth cancer.
Washington D.C., District of ColumbiaAges 25–75 - NCT06555029Recruiting
Oral health help for older adults on Medicaid
This trial is testing an oral health program offered during routine primary care visits for older adults (55+) on Medicaid. It aims to see if adding dental care support to regular check-ups can improve health.
Cleveland, OhioAges 55 years+ - NCT06576622Recruiting
Periodontal disease, bacteria, and miscarriage
This study looks at whether gum disease and oral bacteria are linked to repeated pregnancy loss. If you have had multiple miscarriages, your gum health may play a role.
ToulouseAges Up to 18 years - NCT07619729Enrolling by invitationPhase 4
Oral Health Program for People With Type 2 Diabetes
This study tests whether a text-message and online program about caring for your teeth and gums can help people with type 2 diabetes. Researchers want to see if better oral health habits improve overall health outcomes.
Long Island City, New YorkAges 18 years+
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Common questions
- Are there clinical trials for periodontal diseases?
- Yes. Clin2 currently lists 108 recruiting periodontal diseases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontal diseases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontal diseases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.