Clinical trials
Periodontal Diseases clinical trials
Below are recruiting periodontal diseases clinical trials, each written for real people, not researchers. We’re tracking 105 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07535177Recruiting
Gas6 and MerTK Protein Markers in Gum Disease
This study measures two proteins (Gas6 and MerTK) in the blood and gum tissue of people with and without gum disease to better understand how these proteins relate to periodontal health. Results may help doctors identify new ways to diagnose or treat gum disease in the future.
Bolu, BoluAges 18 years+ - NCT06149585Recruiting
Bacteria changes in gum disease patients getting all dental implants
This study looks at how bacteria in your mouth change when all your teeth are removed and replaced with dental implants. If you have severe gum disease and need all your teeth extracted, joining this trial could help researchers understand your healing process.
Cleveland, OhioAges 21 years+ - NCT07274189Recruiting
Gum health and sodium bicarbonate toothpaste study
This trial tests whether a sodium bicarbonate (baking soda) toothpaste can improve gum health compared to a standard toothpaste. If you have some gum problems (but not too severe), it might help.
PlymouthAges 18 years+ - NCT07257887Recruiting
Testing OROXID oral solution for gum disease
This trial tests a mouth rinse (OROXID) to see if it helps treat advanced gum disease (periodontitis). You may qualify if you have at least three deep gum pockets and have not had dental cleanings or used antibiotics recently.
LjubljanaAges 18 years+ - NCT07873697Recruiting
Gum disease and dry eye study
This study looks at whether people who have gum disease (periodontitis) are more likely to have dry eye disease. If you have both conditions, taking part could help doctors understand how they might be connected and improve care.
Sulaymaniyah, As Sulaymaniyah GovernorateAges 30–65 - NCT07707063RecruitingPhase 4
Gum disease treatment with I-PRF, iodine, or laser in smokers and non-smokers
This trial tests whether adding I-PRF (a concentrate from your own blood), povidone-iodine, or laser treatment to standard deep-cleaning helps smokers and non-smokers with gum disease. You may qualify if you have moderate to severe gum disease with at least one bleeding pocket in each area of your mouth.
Tunis, Mont FleuryAges 18 years+ - NCT07397884Recruiting
Bone loss and stress markers in implant gum disease
This study looks at markers of bone damage and stress in people with gum disease around dental implants (peri-implantitis). It aims to understand how the body responds, which could help improve treatment.
Keçiören, AnkaraAges 18–65 - NCT07377344Recruiting
Gum health care during pregnancy
This trial tests ways to improve gum health during pregnancy. If you have gum disease or are at risk, the study may provide dental care that could help both you and your baby.
San Francisco, CaliforniaAges 18 years+ - NCT07054008Recruiting
Gum Flap Surgery and Healing
This study looks at how gum surgery (flap surgery) affects healing. It aims to improve recovery for people with gum disease who need surgery.
San Antonio, TexasAges 18–18 - NCT05384132Recruiting
Dental gel trial with deep cleaning for gum disease
This study tests whether a new dental gel used along with deep gum cleaning (scaling and root planing) can improve periodontitis. If you qualify, you would receive standard gum treatment plus the study gel, then be followed over time.
Birmingham, AlabamaAges 18–85 - NCT06262035Recruiting
Gum and implant disease tissue profile study
This study looks at the genetic and bacterial profiles in gum disease and implant infections. It might help find new ways to diagnose or treat these conditions.
StockholmAges 18 years+ - NCT07167771Recruiting
Saliva markers for gum disease: a follow-up study
This study follows up with people who already took part in a previous saliva and gum health study. Researchers want to see if certain substances in saliva can predict gum disease progression over time.
MadridAges 18 years+ - NCT05077618Recruiting
Teeth bacteria study in seniors with and without Alzheimer’s
This study looks at the bacteria in the mouth (periodontal microbiota) to see whether they differ between seniors with Alzheimer’s disease and seniors without it. You may be asked for a sample from your gums/teeth and background health information.
Nice, CHU de NICEAges 18–90 - NCT07604493Recruiting
Italian Doctors' Survey on Oral Health and General Wellness
This study asks Italian general practitioners (family doctors) about their views on how oral health—like teeth and gum health—affects overall body health. Your answers help researchers understand what doctors know and think about the connection between mouth and systemic diseases.
Roma, RMAges 18 years+ - NCT05339178Recruiting
Study of quality of life in gum disease patients on maintenance care
This study asks people with periodontitis (gum disease) who are in ongoing maintenance visits after their active treatment. It looks at how supportive periodontal therapy affects quality of life.
ViennaAges 18–130 - NCT05439330Recruiting
Dental MRI to help diagnose jaw, gum, and tooth problems
This study tests whether a special dental MRI can give useful pictures to diagnose jaw joint problems, tooth-related tissue changes, and gum/inflammation issues, and to help plan some dental implant treatments. If you need imaging for these reasons, the trial may help doctors choose the best next treatment by using clearer, dedicated scans.
AarhusAges 18 years+ - NCT07166224Recruiting
Home treatments for gum disease in older adults with memory issues
This trial tests two simple ways to improve gum health at home: using a special light-activated antibacterial rinse or using a powered toothbrush. It's for older adults who have gum disease and mild memory problems, and aims to see if these easy routines can help keep gums healthier.
Karlskrona, Blekinge CountyAges 60 years+ - NCT07069140Recruiting
Lactoferrin mouthwash for gum health during pregnancy
This study tests if a daily lactoferrin mouthwash can improve gum health in pregnant women with gum disease, without needing antibiotics or other treatments. Researchers want to see if this natural protein helps keep gums healthier during the second trimester.
Pavia, LombardyAges 18–45 - NCT07029360Recruiting
Coenzyme Q10 and Probiotics for Gum Health in Pregnancy
This trial tests whether adding coenzyme Q10 and probiotics to standard gum treatment can improve gum health and reduce inflammation in pregnant women. If you are in your second or third trimester and have gum concerns, this treatment may help both you and your baby.
Pavia, LombardyAges 18 years+ - NCT07824518Recruiting
Comparing two bone graft materials after wisdom tooth removal
This study compares two types of bone graft material used to help healing after removing impacted lower wisdom teeth. It tests whether a graft made from your own tooth works as well as one from a cow (bovine xenograft).
Madrid, MadridAges 18 years+ - NCT07615361Enrolling by invitation
Tooth Graft and Laser Therapy for Dental Implants
This study tests whether material from extracted teeth, combined with low-level laser treatment, can help bone heal better before dental implants are placed. The goal is to improve implant success and reduce bone loss after tooth removal.
Istanbul, UskudarAges 18–65 - NCT04669717RecruitingPhase 4
Testing antibiotic dosing alongside periodontal treatment
This study tests how antibiotics should be added to standard gum (periodontal) treatment, including dosing and blood-level timing. It may help people whose gum disease is severe, by improving how antibiotics are used with routine dental care.
Geneva, Canton of GenevaAges 18–80 - NCT06110143Recruiting
Gum health and pregnancy complications study
This study looks at how gum disease (periodontitis) during pregnancy might affect pregnancy outcomes. It may help you if you have gum disease and want to learn more about its impact on your pregnancy.
Holbæk, HolbaekAges 16–48 - NCT06755372Recruiting
TLR-4 in gum disease patients with kidney failure
This study looks at a specific immune marker (TLR-4) in people with gum disease, comparing those who also have end-stage kidney disease (on dialysis) to those who are otherwise healthy. The goal is to understand how gum disease might be different when kidney failure is also present.
Al Fayyum, Faiyum GovernorateAges 30–60
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Common questions
- Are there clinical trials for periodontal diseases?
- Yes. Clin2 currently lists 105 recruiting periodontal diseases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontal diseases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontal diseases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.