Clinical trials
Perioperative clinical trials
Below are recruiting perioperative clinical trials, each written for real people, not researchers. We’re tracking 332 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05912257Recruiting
Nutrition program before and after surgery to protect function
This study tests whether an “optimizing nutrition” plan before and after cancer surgery can help older adults maintain physical strength and daily functioning. You may be randomly assigned to the nutrition program or another study group, and you’ll be asked about diet and physical function.
Durham, North CarolinaAges 55 years+ - NCT05935358RecruitingPhase 4
Nuwiq added around surgery for people with hemophilia A
This Phase 4 study looks at how well Nuwiq works to manage bleeding risk around the time of major elective surgery in people with severe hemophilia A who already take emicizumab to prevent bleeds. It may help your surgical team plan safer blood-clotting support during and after surgery.
Dallas, TexasAges 12 years+ - NCT05855200RecruitingPhase 3
Dostarlimab around surgery for certain untreated colon cancers
This trial studies dostarlimab given around the time of colon cancer surgery for people with untreated, resectable (operable) stage T4N0 or stage III colon cancer that has specific tumor markers. It may help shrink or eliminate the cancer before or after surgery by boosting the immune response.
Tucson, ArizonaAges 18 years+ - NCT05812755RecruitingPhase 4
Study drug effects on blood vessels and organs in heart surgery
This Phase 4 trial studies vericiguat-like stimulation (a type of medicine that affects blood-vessel signaling) around the time of planned open-heart surgery. It aims to see whether this can change blood-vessel “reactivity” and reduce injury to organs during and after surgery.
Nashville, TennesseeAges 18 years+ - NCT05782829Recruiting
L-tyrosine to reduce stress during outpatient hernia surgery
This trial studies whether an L-tyrosine supplement before surgery can reduce stress or anxiety around the time of anesthesia and recovery. It is for adults having outpatient surgery for an inguinal hernia under general anesthesia.
MonacoAges 18–75 - NCT05774717RecruitingPhase 1
Tranexamic acid for bleeding after open nose surgery
This Phase 1 study tests whether tranexamic acid (a medicine that helps reduce bleeding) can lessen bleeding, swelling, and bruising after open rhinoplasty. You may be asked to take it around the time of surgery if you meet safety and lab criteria.
Nashville, TennesseeAges 18 years+ - NCT05429970Recruiting
Reducing stress before ovarian cancer surgery with two medicines
This study tests whether giving two commonly used medicines before surgery—one that can lower stress on the body (a beta-blocker) and one that reduces inflammation (a COX-2 inhibitor)—can improve outcomes compared with standard care. It’s for people with advanced ovarian, fallopian tube, or primary peritoneal cancer who are having open surgery.
Basking Ridge, New JerseyAges 18 years+ - NCT05380531Recruiting
Personalized pain plan for planned C-section using opioid options
This trial tests a personalized approach to pain control during and after a scheduled C-section. It may help by matching pain medicine choices to each person’s needs, including the use of in-hospital opioids for relief.
Indianapolis, IndianaAges 18 years+ - NCT05367609Recruiting
Personalized pain plan for kids getting spine fusion surgery
This trial tests a personalized plan to manage pain around the time of pediatric posterior-lateral spinal fusion surgery. It aims to improve comfort and reduce the chance of pain or opioid problems after surgery by tailoring pain medicines to the child.
San Francisco, CaliforniaAges 10–21 - NCT05257746Recruiting
Testing bladder and rectal function after rectal surgery
This study follows people after rectal surgery to check how well the rectum and urinary (bladder) functions work over time. It may help doctors better understand recovery and what can improve quality of life after surgery.
Dresden, SaxonyAges 18 years+ - NCT05199025Recruiting
Study of blood and lab markers around major surgeries
This study checks blood and other lab “biomarkers” during the time before and after major surgeries to see if they can help guide perioperative care. You might be eligible if you are having certain planned heart, lung, GI, or blood-vessel surgeries and can give informed consent.
Breda, North BrabantAges 18 years+ - NCT05015296Recruiting
Immune cells and recovery in colorectal cancer surgery
This trial looks at how your immune cells change before and after surgery for colorectal cancer, and whether those changes affect your long-term recovery. It may help doctors predict outcomes and improve care.
Beijing, Beijing MunicipalityAges 18–85 - NCT04911816RecruitingPhase 1/Phase 2
Pre-surgery chemo plus oral hydroxychloroquine for pancreatic cancer
This trial studies giving chemo and hydroxychloroquine before surgery for resectable pancreatic cancer. The goal is to shrink the tumor and improve the chances of successful removal.
Morgantown, West VirginiaAges 18 years+ - NCT04880265Recruiting
Study heart rhythm changes after open-heart surgery
This study looks at how often and how long an irregular heartbeat (atrial fibrillation) happens after planned open-heart surgery. It aims to better understand the “burden” of this rhythm problem, which could help improve care for future patients.
Boston, MassachusettsAges 20–90 - NCT02124499Recruiting
Study links genes to complications after scheduled surgery
This study looks at how certain genetic differences may affect the risk of complications and recovery outcomes after surgery. It may help doctors understand who is more likely to have problems around the time of an operation.
BernAges 18 years+ - NCT04832568Recruiting
EEG monitoring to predict and prevent postoperative delirium
This study checks brain-wave signals during heart surgery (using EEG monitoring) to understand who is at risk for confusion after surgery. If you qualify, your team will track your thinking after the operation to help reduce or better manage postoperative delirium.
Wuhan, HubeiAges 18 years+ - NCT04091724Recruiting
EEG monitoring during surgery to reduce delirium in children
This study checks whether using an EEG machine (small sensors that record brain electrical activity) during elective surgery can help prevent or lessen emergence delirium—confusion and agitation right after waking up. It focuses on children under 16 and compares their experience around the time they come out of anesthesia.
Wuhan, HubeiAges Up to 16 years - NCT03954678Recruiting
Exercise program during hospital care for urologic surgery
This study looks at whether doing an exercise routine around the time of urologic (urinary tract) surgery is safe and helpful for recovery. It asks you to do daily steps, answer questionnaires, and allow routine bloodwork.
Atlanta, GeorgiaAges 18 years+ - NCT03415620Recruiting
Music listening during surgery to reduce anxiety and pain
This study tests whether listening to music around the time of surgery can lower anxiety and pain, reduce how much pain medicine you need, and improve satisfaction. You may be asked to fill out brief questionnaires before and after your procedure.
SingaporeAges 21–70 - NCT00493688Recruiting
Tracking energy changes during surgery in esophageal or lung cancer
This study looks at how your body uses energy during surgery and whether those patterns relate to how well you do after surgery. It may help doctors better predict outcomes for people with newly diagnosed esophageal or lung cancer who are preparing for treatment.
Houston, TexasAges 18 years+
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Common questions
- Are there clinical trials for perioperative?
- Yes. Clin2 currently lists 332 recruiting perioperative studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a perioperative trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a perioperative trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.