Clinical trials
Phase 1 clinical trials
Below are recruiting phase 1 clinical trials, each written for real people, not researchers. We’re tracking 303 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07456046RecruitingPhase 1
Study of D3S-003 for advanced solid tumors with KRAS G12D mutation
This trial tests a new medicine called D3S-003 in people whose cancer has a specific change (mutation) known as KRAS G12D. The medicine aims to target and attack cancer cells with this mutation. It may be an option if standard treatments have stopped working or are not available.
New Haven, ConnecticutAges 18 years+ - NCT07462377RecruitingPhase 1
Testing EPI-326 for EGFR-mutant lung and head & neck cancers
This trial tests a new drug, EPI-326, in people with advanced lung or head & neck cancers that have certain EGFR changes. The goal is to see if it is safe and may help shrink the cancer.
Los Angeles, CaliforniaAges 18 years+ - NCT05447338Recruiting
Manual therapy for neck pain with limited neck motion
This trial tests whether hands-on/manual physical therapy helps people with neck pain and reduced neck movement. It may help improve motion and reduce symptoms if your neck pain fits the trial’s type and severity.
CórdobaAges 25–50 - NCT06800729RecruitingPhase 1
Testing safety of TIX100 in healthy volunteers
This phase 1 study tests an experimental drug called TIX100 in healthy volunteers to check its safety and how the body processes it. The results will help determine if the drug can be studied in future trials for conditions like obesity or metabolic disorders.
Chula Vista, CaliforniaAges 18–70 - NCT07419841RecruitingPhase 1
A study of CTX-10726 for certain advanced cancers
This trial tests a new drug called CTX-10726 in people with advanced kidney, liver, stomach, or uterine cancer that has not responded to standard treatments. The goal is to see if the drug is safe and tolerable.
Phoenix, ArizonaAges 18 years+ - NCT07423000RecruitingPhase 1
Testing PVT401 in healthy volunteers
This study tests a new investigational drug called PVT401 in healthy people. It is a first-in-human study to see how the drug is handled by the body and to check for any side effects.
Melbourne, VictoriaAges 18–65 - NCT05829629RecruitingPhase 1
Test of an HPV vaccine-like treatment for HPV16 in women
This Phase 1 study tests FluBHPVE6E7, a new treatment designed to help the immune system respond to HPV16. It mainly checks safety and the best dose, and may help your body clear or control HPV over time.
BratislavaAges 18–49 - NCT07382817RecruitingPhase 1
A study of CAR T cells for patients with certain T or NK cell cancers
This trial tests whether a new treatment, called CAR T cells that target CD94, can help people with specific types of T or NK cell lymphoma or leukemia that have not responded to other treatments or have come back. The goal is to see if it is safe and works against the cancer.
Houston, TexasAges 18 years+ - NCT07382726RecruitingPhase 1
Study of izalontamab brengitecan plus adagrasib for KRAS G12C lung cancer
This trial tests a combination of two targeted drugs for people with advanced non-small cell lung cancer that has a specific KRAS G12C mutation and has stopped responding to a previous KRAS G12C inhibitor. The goal is to see if the combination is safe and works better than the single drug alone.
Houston, TexasAges 18 years+ - NCT07376707RecruitingPhase 1
Study of TGI-5 alone or with nivolumab for advanced solid tumors
This trial tests a new drug called TGI-5, either by itself or combined with another drug (nivolumab), for people with advanced cancer that hasn't responded to standard treatments. It's looking for patients with certain types of solid tumors, especially colorectal, melanoma, lung, or others that have stopped responding to therapy.
ShanghaiAges 18 years+ - NCT07371338RecruitingPhase 1
Testing a new drug for advanced Parkinson's
This trial tests an investigational drug called IPS101A in people with advanced Parkinson's disease. It aims to see if the drug is safe and how well it works when standard treatments are no longer enough.
SeoulAges 50–80 - NCT07362888RecruitingPhase 1
Testing a new drug ADCE-B05 for advanced solid tumors
This trial tests a new investigational drug called ADCE-B05 in people with advanced solid tumors that have not responded to other treatments. The goal is to see if it is safe and effective.
Springdale, ArkansasAges 18 years+ - NCT07364877Enrolling by invitationPhase 1
Safety study of DW4421 and DW4421S in healthy adults
This trial tests two forms of a new drug, DW4421 and DW4421S, to see how safe they are and how the body processes them. It is for healthy volunteers aged 19 to 50.
Cheongju-siAges 19–50 - NCT07357870RecruitingPhase 1
Cream study for facial vitiligo
This trial tests a new cream for vitiligo on the face or neck. It aims to see if the cream can help bring color back to white patches.
Ankara, TurkeyAges 18–60 - NCT07347171RecruitingPhase 1
Testing CG009301 for blood cancers that returned or didn't respond
This trial tests a new drug called CG009301 for people with blood cancers that have come back or haven't responded to standard treatments. The goal is to see if the drug is safe and works against these cancers.
NanchangAges 18–75 - NCT07343245RecruitingPhase 1
Investigating DW4421 with common pain relievers in healthy adults
This trial tests a new drug, DW4421, when taken together with three different NSAID pain relievers to see if it's safe and how they interact. It is for healthy adults who want to help research a new treatment option.
Cheongju-siAges 19–50 - NCT07335913RecruitingPhase 1
Testing SBS-147 in healthy adults for safety
This study tests a new drug, SBS-147, in healthy adults to see if it's safe and how the body processes it. It may help find the right dose for future studies in people with certain conditions.
Cypress, CaliforniaAges 18–55 - NCT07330674RecruitingPhase 1
Safety study of ABF-101 in healthy people and AMD patients
This trial tests the safety of a new drug called ABF-101 in two groups: healthy volunteers (Part A and B) and people with age-related macular degeneration (AMD, Part C). If you join, you will help researchers understand how the drug affects the body and if it's safe enough to study further.
Dallas, TexasAges 18–50 - NCT07317505RecruitingPhase 1
Study of JMT108 for Advanced Solid Tumors
This trial tests a new drug called JMT108 in people with advanced solid tumors that have not responded to standard treatments or for which no standard treatment exists. The study aims to see if the drug is safe and how it affects the body.
Huntersville, North CarolinaAges 18 years+ - NCT06864884RecruitingEarly Phase 1
Study of ARC-001 for wisdom teeth removal
This trial tests a new medicine called ARC-001 in people who are scheduled to have their wisdom teeth taken out. The goal is to see if it's safe and how it affects pain and healing.
Salt Lake City, UtahAges 18–55 - NCT06828393RecruitingPhase 1
Study of S-1117 in healthy volunteers
This study tests a new medicine called S-1117 in healthy volunteers to see how safe it is and how it works in the body. It is a first-in-human trial that helps researchers learn about the medication before testing it in people with a condition.
Adelaide, South AustraliaAges 18–65 - NCT07311993RecruitingPhase 1
Study of CLR 125 for triple negative breast cancer
This trial tests an experimental drug called CLR 125 in people with triple negative breast cancer that has worsened after at least one prior treatment. It aims to see if the drug is safe and how it affects the cancer.
Jacksonville, FloridaAges 18 years+ - NCT07306754RecruitingPhase 1
A Safety Study of ABBV-243 in Healthy Adults
This study tests a new drug called ABBV-243 in healthy adults to see if it is safe and how the body processes it. Participation helps researchers understand the drug before studying it in people with a disease.
Grayslake, IllinoisAges 18–60 - NCT07304791RecruitingPhase 1
Testing beam-103 safety in healthy volunteers
This trial tests a new drug called BEAM-103 in healthy people to see if it's safe and how the body processes it. It's a single-blind study, meaning you won't know if you get the drug or a placebo.
LondonAges 18–55
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Common questions
- Are there clinical trials for phase 1?
- Yes. Clin2 currently lists 303 recruiting phase 1 studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a phase 1 trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a phase 1 trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.