Clinical trials
Preclinical Alzheimer's Disease clinical trials
Below are recruiting preclinical alzheimer's disease clinical trials, each written for real people, not researchers. We’re tracking 17 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07158905RecruitingPhase 1
Tau vaccine study for early Alzheimer's prevention
This study tests a vaccine that targets tau protein, which is linked to Alzheimer's disease. It is for older adults who have no memory problems yet but have biological signs of early Alzheimer's, to see if the vaccine can prevent or slow down the disease.
Boca Raton, FloridaAges 65–80 - NCT06416072Enrolling by invitation
Blood marker study for people not eligible for Alzheimer's prevention trials
This study looks at blood markers in people who were part of an early Alzheimer's prevention study but did not qualify for it because their amyloid levels were too low. It aims to understand brain changes and possibly find ways to detect Alzheimer's even earlier.
Birmingham, AlabamaAges 55–80 - NCT07167966Enrolling by invitationPhase 2
Alzheimer's tau vaccine study (AADvac1)
This trial tests a vaccine that targets tau tangles in the brain, which are linked to Alzheimer's. It is part of a larger platform study that combines different experimental treatments.
San Francisco, CaliforniaAges 50–80 - NCT06957418RecruitingPhase 2
Alzheimer's tau drug study for early stage patients
This trial tests a treatment targeting tau protein buildup in the brain for people with early Alzheimer's. You may join if you have memory or thinking changes but are still living independently, and brain scans show both amyloid and tau clumps.
San Francisco, CaliforniaAges 50–80 - NCT06827678Recruiting
Study of Alzheimer’s disease using brain scans in China
This study uses brain imaging to understand early changes in Alzheimer's disease. It may help people with or without memory problems learn more about their condition and support future treatments.
ShanghaiAges 45–90 - NCT06956300Recruiting
TMS to help with thinking and memory in aging
This study uses a noninvasive brain stimulation technique called TMS to see if it can slow cognitive decline in older adults who are healthy or have very early signs of Alzheimer's disease. It aims to improve memory and thinking.
Boston, MassachusettsAges 40–99 - NCT07031687Recruiting
A new brain stimulation study for early Alzheimer's
This study tests a non-invasive brain stimulation method (temporal interference stimulation) to see if it can improve memory in people with early signs of Alzheimer's disease. It aims to understand how the stimulation affects brain function.
Sanya, HainanAges 60–80 - NCT07571161RecruitingPhase 3
Donanemab for early Alzheimer's disease in Chinese participants
This trial tests a drug called donanemab in people who have early signs of Alzheimer's disease (amyloid buildup in the brain) but are still thinking clearly. The goal is to see if the drug can slow or prevent cognitive decline before memory problems start.
BeijingAges 55–80 - NCT07598617Recruiting
Testing a New Computer Memory Assessment for Early Cognitive Changes
This study evaluates a new computer-based test to detect early memory and thinking changes before they progress to dementia. Researchers are looking for adults 65+ who've noticed subtle cognitive changes in the last 5 years to help refine and test this assessment tool.
Plymouth, DevonAges 65 years+ - NCT06538311RecruitingEarly Phase 1
TMS treatment for early Alzheimer's disease
This study tests whether a non-invasive brain stimulation treatment called TMS (transcranial magnetic stimulation) can help people with early Alzheimer's disease or related memory problems. It's a safe, gentle way to stimulate brain cells using magnetic pulses.
Boston, MassachusettsAges 40–99 - NCT06215274Recruiting
Leisure activities and early Alzheimer's study
This trial looks at how engaging in mentally stimulating leisure activities (like puzzles, reading, or games) may affect brain health in people with early memory concerns. Researchers want to understand the brain changes that happen with these activities.
Fuzhou, FujianAges 60 years+ - NCT07298876Enrolling by invitation
Ultrasound for memory and sleep in early Alzheimer's
This study tests if a gentle ultrasound treatment to the brain can help improve memory and sleep quality in people with very early Alzheimer's disease. If you have mild memory issues and trouble sleeping, this low-intensity approach might be a safe option to explore.
Hong Kong, Tai Po DistrictAges 60–85 - NCT06121544Recruiting
Pre-Alzheimer's Study: Find Early Brain Changes
This study is looking for healthy volunteers to help detect the very earliest signs of Alzheimer's disease—before memory loss starts. You will have tests like memory checks, blood draws, brain scans, and a spinal tap to look for Alzheimer's-related changes.
MalmöAges 50–80 - NCT04134923Recruiting
Brain PET scan study using a blood-flow and plaque tracer
This study uses PET/CT/MRI imaging to look for brain “imaging biomarkers” in people across the Alzheimer’s disease range. It may help researchers better understand how Alzheimer’s changes the brain over time and improve future treatments.
St Louis, MissouriAges 18 years+ - NCT04701177Enrolling by invitation
Smartphone-based study of brain biomarkers in memory clinic patients
This observational study follows people with (or at risk for) Alzheimer’s-related brain changes and a comparison group without them. It uses clinic visits, cognitive testing, questionnaires, and possibly a spinal fluid test to better understand brain biomarkers and how they relate to thinking and daily life.
Corfu, CorfuAges 45 years+ - NCT03687710Enrolling by invitation
Alzheimer’s registry for people with memory concerns or risk
This is a research registry that helps doctors compare how different memory and Alzheimer’s risk groups change over time. It may help researchers learn which people are more likely to develop Alzheimer’s and how to better track early changes.
New York, New YorkAges 18–99 - NCT06561906Recruiting
Early Alzheimer's detection using scans, genetics and blood
This study uses brain scans, blood tests, and genetic information to find early signs of Alzheimer's disease before memory problems start. It aims to predict who might develop Alzheimer's in the future.
Nanjing, JiangsuAges 50–79
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Common questions
- Are there clinical trials for preclinical alzheimer's disease?
- Yes. Clin2 currently lists 17 recruiting preclinical alzheimer's disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a preclinical alzheimer's disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a preclinical alzheimer's disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.