Clinical trials
Psychotherapy clinical trials
Below are recruiting psychotherapy clinical trials, each written for real people, not researchers. We’re tracking 145 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05585229RecruitingPhase 2
Psilocybin therapy to help you taper opioid pain medicine
This Phase 2 study tests a structured, therapist-led treatment using standardized natural psilocybin to help people reduce or stop long-term opioid use for chronic (non-cancer) pain. It’s mainly for those who have tried tapering before but couldn’t, and who are motivated to try again.
Kelowna, British ColumbiaAges 19–75 - NCT05925322Recruiting
Social reward therapy for depression-related suicidal thoughts
This study looks at whether “social reward” psychotherapy can change brain activity and reduce suicidal thoughts in adults ages 50–80 who also have major depression. You may be offered psychotherapy along with brain scans to see how your brain responds over time.
New York, New YorkAges 50–80 - NCT05929911Recruiting
Talk therapy for PTSD in people living with HIV
This trial tests whether trauma-focused psychodynamic talk therapy can reduce symptoms of post-traumatic stress disorder (PTSD) in people who also live with HIV. It may help by offering structured therapy alongside stable medication.
The Bronx, New YorkAges 18–65 - NCT06044675RecruitingPhase 2
MDMA plus therapy for PTSD – a study with a partner
This study tests whether MDMA, combined with a type of talk therapy called CBCT (cognitive behavioral conjoint therapy), is more effective than CBCT alone for treating PTSD. You and a close partner will both participate in therapy sessions and take MDMA together.
Toronto, OntarioAges 18–80 - NCT06200155RecruitingPhase 2
Psilocybin therapy for advanced cancer patients with anxiety or depression
This trial tests whether a drug called psilocybin, given with therapy, can help people with advanced cancer who are feeling anxious or depressed. You must have a stable cancer and be willing to travel to Houston for treatment.
Houston, TexasAges 25 years+ - NCT06439043Recruiting
Testing adapted EMDR for depression online vs in person
This study looks at a talking therapy called EMDR adapted for depression. It compares doing the sessions online versus face-to-face to see which works better.
KohatAges 20–50 - NCT06443125Recruiting
Natural psychotherapy for obsessive-compulsive disorder
This study tests a natural psychotherapy approach for people with obsessive-compulsive disorder or compulsive behavior. It aims to understand how this therapy works and may help manage symptoms.
Hefei, AnhuiAges 15–60 - NCT06473155Recruiting
Teens' talents and life projects study
This study explores how discovering your talents and planning for your future affects life satisfaction. It aims to help teenagers build a positive outlook and find meaning in their lives.
Barcelona, CataloniaAges 14–18 - NCT06501261Recruiting
CALM therapy for advanced cancer patients in Chile
This study tests a type of talk therapy called CALM (Managing Cancer and Living Meaningfully) for people with advanced or metastatic cancer in Chile. The goal is to see if it helps with emotional well-being and coping.
Providencia, Santiago MetropolitanAges 18 years+ - NCT06559826RecruitingPhase 2
Ketamine therapy with or without talk for depression
This study compares ketamine alone to ketamine combined with psychotherapy for treating depression. It may help if you have moderate to severe depression and want to see if adding talk therapy improves results.
New York, New YorkAges 18–90 - NCT06991166Recruiting
A therapy study for new mothers with depression whose baby is in the NICU
This study tests a new talk therapy program to help new mothers with depression whose babies are in the neonatal intensive care unit (NICU). You may join if you gave birth in the last year and have signs of depression, like a diagnosis or certain feelings.
Hackensack, New JerseyAges 18 years+ - NCT07129070Recruiting
Just-in-Time Training for Youth Mentors
This trial tests a new training program for mentors working with middle and high school students. It aims to help mentors better support youth who may be experiencing depression.
Minneapolis, MinnesotaAges 12 years+ - NCT07290491RecruitingPhase 3
Spiritual care or therapy for advanced cancer patients
This trial compares the effects of adding spiritual care or psychotherapy to standard palliative care for patients with advanced cancer that cannot be cured. It aims to see if these extra supports improve quality of life and emotional well-being.
Houston, TexasAges 18 years+ - NCT07312760Recruiting
Talking therapy for existential distress in advanced cancer
This trial compares a short-term psychodynamic therapy (ORPHYS) with usual care for people with advanced cancer who are struggling with existential distress, such as loss of hope, fear of death, or loneliness. It aims to see if this therapy can help improve emotional well-being.
DüsseldorfAges 18 years+ - NCT06954025Enrolling by invitationPhase 2
MDMA therapy for PTSD inpatients
This trial tests whether high-dose MDMA, given during intensive inpatient therapy, can help people with PTSD that hasn't improved with other treatments. It takes place at a specialized trauma center and involves several therapy sessions with the drug.
OegstgeestAges 18 years+ - NCT06538675Enrolling by invitation
Comparing different talk therapies for adults
This study compares different types of talk therapy to see which works best. It is for adults who need psychotherapy and can complete questionnaires in German.
Salzburg, State of SalzburgAges 18–80 - NCT04763720Enrolling by invitation
Therapy for kids with attachment and trauma difficulties
This trial studies a special type of parent-and-child therapy called Dyadic Developmental Psychotherapy (DDP) for children who struggle with relationships or attachment after trauma, including neglect or emotional abuse. It may help families improve safety, closeness, and communication through guided sessions.
Skien, Vestfold Og TelemarkAges 5–99 - NCT06630351Enrolling by invitation
Meaning-centered group therapy for caregiver wellbeing
This study tests whether group therapy focused on meaning and purpose can improve the wellbeing of people caring for someone with advanced cancer or another serious illness. Caregivers will join virtual group sessions and complete questionnaires about their feelings and stress.
Jacksonville, FloridaAges 18 years+ - NCT06824532Recruiting
Veterans' views on ketamine therapy for depression and end-of-life
This study surveys older veterans to understand their perceptions of ketamine-assisted psychotherapy as a treatment for depression and end-of-life distress. Your responses may help improve care for veterans facing similar challenges.
Albany, New YorkAges 65 years+ - NCT06623981Recruiting
Treating maternal depression in an urban asthma clinic
This study tests whether treating depression in Black mothers of children with asthma can improve both the mother's mood and the child's asthma. It offers support for mothers who are feeling down and may help their child's asthma get better.
Washington D.C., District of ColumbiaAges Any age - NCT06369532Recruiting
Brain stimulation and therapy to stop worrying
This trial combines a gentle brain stimulation technique called tDCS with cognitive-behavioral therapy (a type of talk therapy) to help people with generalized anxiety disorder or depression stop worrying.
Ghent, East-FlandersAges 18–70 - NCT06273137Recruiting
Positive affect treatment for teens with early adversity
This trial tests a treatment designed to improve positive emotions in adolescents who have experienced stressful early life events. It may help your teen build resilience and emotional wellbeing.
Irvine, CaliforniaAges 12–16 - NCT05974553Recruiting
Dialectical behavior therapy for justice-involved veterans
This study tests whether dialectical behavior therapy (DBT, a structured therapy skills program) can help veterans with stress or behavior challenges related to justice system involvement. It may help by teaching practical coping skills in a group setting.
Aurora, ColoradoAges 18 years+ - NCT05766592RecruitingPhase 3
Therapy for sexual or gender-minority adults and a rejecting parent
This study tests a therapy program tailored for sexual and gender-minority adults who are dealing with strong rejection from a parent. It also involves that parent in sessions to help improve support and reduce anxiety or depression.
New York, New YorkAges 20 years+
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Common questions
- Are there clinical trials for psychotherapy?
- Yes. Clin2 currently lists 145 recruiting psychotherapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a psychotherapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a psychotherapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.