Clinical trials · California
Rheumatoid arthritis clinical trials in California
We’re tracking 26 recruiting rheumatoid arthritis studies with a site in California — including Phase 1, Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07412704RecruitingPhase 1/Phase 2
Study of BMS-986528 for hard-to-treat rheumatoid arthritis
This trial tests a new drug called BMS-986528 for people with rheumatoid arthritis that is difficult to treat. It aims to see if the drug can help when other treatments haven't worked well.
La Jolla, CaliforniaAges 18–65 - NCT04748809Recruiting
Diet trial for rheumatoid arthritis inflammation
This study tests whether an anti-inflammatory diet can help people with rheumatoid arthritis by lowering inflammation and disease activity. You may join if your symptoms are currently mild to moderate and you haven’t recently changed medications or your treatment plan.
La Jolla, CaliforniaAges 18 years+ - NCT05961592RecruitingPhase 1
Study drug R-2487 for people with active rheumatoid arthritis
This Phase 1 study tests how the drug R-2487 behaves in the body and looks at early safety in adults with active rheumatoid arthritis. If you have ongoing joint inflammation despite standard treatments, this trial may offer a chance to try an investigational therapy under close monitoring.
San Diego, CaliforniaAges 18–75 - NCT06972446RecruitingPhase 2
Study of targeted therapies for rheumatoid arthritis
This trial tests different targeted treatments for people with rheumatoid arthritis who have tried one or two biologic or targeted synthetic drugs but still have symptoms. You need to be taking a stable dose of methotrexate.
Beverly Hills, CaliforniaAges 18 years+ - NCT06902519RecruitingPhase 1
Study of a new drug for rheumatoid arthritis
This trial tests an experimental drug for people with rheumatoid arthritis who have not had success with other treatments. It aims to see if the drug can help reduce joint pain and swelling.
Tujunga, CaliforniaAges 18–75 - NCT07276581RecruitingPhase 2
Testing AZD1163 for active rheumatoid arthritis
This study tests a new medication called AZD1163 for people with rheumatoid arthritis (RA) that hasn't responded well enough to standard treatments. It aims to see if the drug can safely reduce joint swelling and pain.
San Leandro, CaliforniaAges 18 years+ - NCT06201416RecruitingPhase 1
Single dose of SBT777101 for rheumatoid arthritis
This study tests a single dose of an experimental drug called SBT777101 for people with moderate to severe rheumatoid arthritis who have already tried and failed at least two advanced treatments. The goal is to see if it is safe and how the body handles it.
San Francisco, CaliforniaAges 18–70 - NCT07607964RecruitingPhase 1
ABBV-519 Study for Lupus or Rheumatoid Arthritis
This early-stage trial tests a new drug called ABBV-519 given as infusions or injections to treat systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA) in adults whose disease hasn't responded well to other treatments. Researchers will measure how safe the drug is, how it moves through your body, and whether it helps reduce symptoms.
Los Angeles, CaliforniaAges 18–75 - NCT06916806RecruitingPhase 1
Study of AZD5492 for lupus, myositis, or rheumatoid arthritis
This trial tests an investigational drug called AZD5492 for people with active lupus, inflammatory myositis, or rheumatoid arthritis who haven't responded well to other treatments. It aims to see if the drug is safe and how it works in the body.
La Jolla, CaliforniaAges 18–70 - NCT07163221Recruiting
At-home ultrasound therapy for rheumatoid arthritis
This trial tests if a device that uses ultrasound waves, used at home, can help treat rheumatoid arthritis (RA). It is for people with moderate to severe RA who still have symptoms despite taking standard medications.
Covina, CaliforniaAges 18 years+ - NCT06991114RecruitingPhase 2
AlloNK and rituximab for relapsing rheumatologic diseases
This trial tests a new natural killer (NK) cell therapy called AlloNK given with rituximab for people with certain autoimmune diseases (rheumatoid arthritis, Sjögren's disease, inflammatory myopathies, or systemic sclerosis) that have not responded well to standard treatments. The goal is to see if this combination can better control the disease.
Chula Vista, CaliforniaAges 18 years+ - NCT07409103RecruitingPhase 2
Testing ELV001 for active rheumatoid arthritis
This study tests a new medication, ELV001, for people with active rheumatoid arthritis who haven't improved enough with methotrexate and a TNF inhibitor. The goal is to see if different doses of ELV001 are safe and can help reduce joint pain and swelling.
Tustin, CaliforniaAges 18–75 - NCT07137598RecruitingPhase 2
A study of RO7790121 for moderate to severe rheumatoid arthritis
This study tests a new drug, RO7790121, for people with rheumatoid arthritis (RA) who have not gotten better with or could not tolerate common treatments like TNF inhibitors or JAK inhibitors. It aims to see if the drug is safe and can help reduce joint pain and swelling.
La Jolla, CaliforniaAges 18 years+ - NCT03816345RecruitingPhase 1
Nivolumab for advanced cancer with autoimmune conditions
This Phase 1 study tests nivolumab, an immunotherapy “anti-cancer accelerator,” in people with advanced cancer who also have an autoimmune disorder. It aims to see if nivolumab can be given safely and whether it may help shrink or control cancer.
Palo Alto, CaliforniaAges 18 years+ - NCT03048201Recruiting
Total Knee Replacement Registry Study for a Specific Knee Implant
This study tracks outcomes for people getting a total knee replacement using a specific knee implant system. It may help doctors understand which patients do best and how the implant performs over time.
Rancho Mirage, CaliforniaAges 22 years+ - NCT05603728Recruiting
Follow-up study for Exactech shoulder implants after surgery
This study follows people who get (or already had) a shoulder replacement to see how the implant is doing over time. It may help improve future care by tracking long-term performance and safety.
Stockton, CaliforniaAges 21 years+ - NCT06733935RecruitingPhase 1/Phase 2
Study of NKX019 for immune diseases
This trial tests an investigational cell therapy called NKX019 for people with certain autoimmune diseases like scleroderma, myositis, vasculitis, or rheumatoid arthritis. It aims to see if NKX019 can help control the disease when standard treatments have not worked well enough.
Orange, CaliforniaAges 18–75 - NCT07201558RecruitingPhase 1
Surovatamig safety study for rheumatoid arthritis or lupus
This trial tests surovatamig, a new experimental treatment, to see if it's safe and how the body processes it in adults with moderate-to-severe rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). It may be an option if you've tried other biologic or targeted therapies without success.
Fullerton, CaliforniaAges 18–65 - NCT07295847RecruitingPhase 1
Study of AZD0120 for autoimmune diseases
This trial tests if a new medication, AZD0120, is safe for people with autoimmune diseases. It aims to help patients by targeting the immune system.
Stanford, CaliforniaAges 18–75 - NCT07237659RecruitingPhase 1
Testing safety of NTR-1011 in lupus and rheumatoid arthritis
This trial is testing a new medicine called NTR-1011 to see if it is safe and tolerable for people with lupus or rheumatoid arthritis. If you have active lupus or RA and are on a stable treatment plan, you may be able to join.
Apple Valley, CaliforniaAges 18–75 - NCT04692493RecruitingPhase 3
Testing two treatment paths for active rheumatoid arthritis
This Phase 3 study compares two ways to treat active rheumatoid arthritis: a TNF-blocking biologic versus a targeted pill treatment. It may help people who are not doing well on (or cannot tolerate) certain biologic therapies to find a better, more practical option.
Los Angeles, CaliforniaAges 18 years+ - NCT05003310Recruiting
Splenic stimulation study for active rheumatoid arthritis
This study tests a treatment that stimulates the spleen to help calm symptoms of active rheumatoid arthritis (RA). It’s mainly for people whose RA has not improved enough after several newer arthritis medicines.
Whittier, CaliforniaAges 22–75 - NCT06397677Recruiting
Study of Progressive RA Interstitial Lung Disease
This study is looking at people with rheumatoid arthritis (RA) who also have interstitial lung disease (ILD), a condition that causes scarring in the lungs. It aims to understand how the disease changes over time by using imaging and blood tests, without providing any new treatments right now.
San Francisco, CaliforniaAges 18–90 - NCT07123038Recruiting
Long-term safety study for gene-modified Treg therapy recipients
This study follows people who previously received a gene-modified Treg (regulatory T cell) therapy from Sonoma Biotherapeutics. It checks for long-term safety and does not involve any new treatment.
San Francisco, CaliforniaAges 18–71
Rheumatoid arthritis trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting rheumatoid arthritis studies listed above.
- Research Site · 4 studies
- Medvin Clinical Research · 3 studies
- University of California, San Francisco · 3 studies
- Solace Clinical Research · 2 studies
- Southland Arthritis & Osteoporosis Medical Center · 2 studies
- Stanford Medical Center · 2 studies
- Stanford University · 2 studies
- University of California San Diego Health · 2 studies
What taking part in a rheumatoid arthritis study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Rheumatoid arthritis trials in other states
Common questions
- Are there rheumatoid arthritis clinical trials in California?
- Yes. We're currently tracking 26 recruiting rheumatoid arthritis studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a rheumatoid arthritis study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a rheumatoid arthritis trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New rheumatoid arthritis studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.