Clinical trials
Smokers clinical trials
Below are recruiting smokers clinical trials, each written for real people, not researchers. We’re tracking 54 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07707063RecruitingPhase 4
Gum disease treatment with I-PRF, iodine, or laser in smokers and non-smokers
This trial tests whether adding I-PRF (a concentrate from your own blood), povidone-iodine, or laser treatment to standard deep-cleaning helps smokers and non-smokers with gum disease. You may qualify if you have moderate to severe gum disease with at least one bleeding pocket in each area of your mouth.
Tunis, Mont FleuryAges 18 years+ - NCT07282756Recruiting
Lovastatin gel for gum disease treatment
This study tests whether a lovastatin gel applied to the gums (after a deep cleaning) helps treat gum disease better than cleaning alone. Participants must not have had previous gum treatment or antibiotics recently, and can be a smoker or non-smoker.
Bielsko-Biala, Silesian VoivodeshipAges 18–59 - NCT03862924Recruiting
Study tests standardized e-cigarette effects in people with HIV who smoke
This study looks at how a specific e-cigarette affects health in people who have HIV and smoke cigarettes regularly. You might be able to join if you meet smoking, HIV care, and safety requirements and are not planning to quit right away.
Providence, Rhode IslandAges 18 years+ - NCT07547202Recruiting
Gum Disease Treatment Effects on Saliva in Smokers and Non-Smokers
This study tests whether a non-surgical cleaning procedure for gum disease changes markers in your saliva differently depending on whether you smoke. Researchers want to understand how smoking affects how your mouth heals.
Baghdad, Baghdad GovernorateAges 18 years+ - NCT07367737Enrolling by invitation
Comparing histatin-1 levels in smokers and non-smokers with gum disease
This study looks at a protein called histatin-1 in your saliva to see how it changes with gum disease treatment. Researchers want to compare levels between smokers and non-smokers before and after deep cleaning (a non-surgical treatment for periodontitis). It may help understand how smoking affects gum healing.
Baghdad, Medical CityAges Any age - NCT07285122RecruitingPhase 1
Inhaled study drug for healthy smokers and people with COPD
This study tests an inhaled medication called RB042 in healthy adults, healthy smokers, and people with COPD. It aims to see how the drug works in the body and whether it is safe, which could help in developing a new treatment for COPD.
Nedlands, Western AustraliaAges 18–80 - NCT07134426Recruiting
Vaped phenanthrene study for healthy adults
This study is testing a chemical called phenanthrene that is found in e-cigarette vapor. Researchers want to see how the body processes it, so they are looking for healthy people who have tried vaping.
Minneapolis, MinnesotaAges 21 years+ - NCT07118332RecruitingEarly Phase 1
Psilocybin for chronic pain in veterans who smoke
This trial tests if psilocybin can help veterans with chronic pain who also smoke cigarettes. You will take psilocybin in a controlled setting to see if it reduces pain and helps with smoking.
West Haven, ConnecticutAges 21–65 - NCT07027956Recruiting
Smoking and lung function study
This study measures how well your lungs work and how much oxygen is in your blood. It compares smokers and non-smokers to see if smoking affects breathing.
KırşehirAges 18–65 - NCT03199651Recruiting
Study for people with stage IV lung cancer
This study focuses on improving outcomes for people with stage IV non-small cell lung cancer by gathering health, treatment, and lifestyle information. It may help researchers understand what supports survival and care planning, especially for people who are current smokers or recent quitters.
Columbus, OhioAges 18 years+ - NCT05486455Recruiting
Lung cancer screening CT for eligible former and current smokers
This study looks at how well a chest CT scan can detect lung cancer early in people with a significant smoking history. If you qualify, your CT results may help improve future screening for people like you.
MarseilleAges 50–80 - NCT06156527RecruitingPhase 2
Lazertinib alone vs lazertinib plus Avastin for EGFR+ lung cancer in smokers
This trial tests if adding bevacizumab (Avastin) to lazertinib works better than lazertinib alone for advanced non-small cell lung cancer with an EGFR mutation. It is for people who have smoked at least 100 cigarettes in their lifetime.
Suwon, Gyeonggi-doAges 19 years+ - NCT07871656Recruiting
Detecting lung cancer in non-smokers through urine
This study uses a simple urine test to help detect lung cancer in people who have never smoked but have a lung spot (nodule) on their CT scan. It may lead to a new, non-invasive way to check for cancer without needing a biopsy.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07710820Recruiting
Can a heated tobacco product help you stop smoking?
This study tests whether having access to a heated tobacco product (a device that heats tobacco, not burns it) helps current cigarette smokers quit smoking. You'll try four different flavors over a week and then continue using one you like.
Brandon, FloridaAges 21–65 - NCT07673185Recruiting
Omega-3 and low-dose aspirin for gum disease in smokers
This trial tests whether taking omega-3 supplements with low-dose aspirin can improve gum health in smokers with advanced gum disease (stage III periodontitis). It aims to see if this combination safely reduces gum pocket depth and tissue damage.
CairoAges 30–50 - NCT07598136Recruiting
How e-cigarette flavors affect smoking habits
This study looks at whether different flavors in e-cigarettes help smokers quit or reduce regular cigarettes. You'll use e-cigarettes with different flavors while researchers track your smoking habits through a smartphone app.
Maitland, FloridaAges 21–65 - NCT07597213Recruiting
Hyaluronic acid to help gum disease treatment in smokers
This study tests whether adding hyaluronic acid (a natural substance) to standard gum disease treatment helps smokers recover better. Gum disease is serious in smokers, and this treatment might improve healing.
IstanbulAges 18–65 - NCT06575439Recruiting
Study of lung cancer in people who have never smoked
This study looks at why some people who have never smoked develop lung cancer. Researchers will follow participants to learn about predictors and outcomes, with the goal of improving care for non-smokers with lung cancer.
LondonAges 18 years+ - NCT04252781Recruiting
Study for people with new or suspected COPD risk
This study follows people who currently smoke and people who may have newly found COPD (chronic obstructive lung disease) based on breathing test results. It aims to better understand lung disease in real life and what it means for health over time.
Créteil, Île-de-France RegionAges 35 years+ - NCT07390695Enrolling by invitation
Gamified exercise for hardcore smokers who are inactive
This trial tests if a fun, game-like exercise program can help heavy smokers who don't exercise much improve their heart and lung fitness and feel more ready to quit smoking.
Yogyakarta, Special Region of YogyakartaAges 17–45 - NCT07301489Recruiting
Heart study for lung screening participants
This trial adds a heart health check to an existing lung cancer screening study. It looks at old chest CT scans to assess heart disease risk and asks you to return for a follow-up visit one year later.
Lørenskog, AkershusAges 60–79 - NCT07250230Recruiting
Nicotine patch for pain after lung surgery in male smokers
This study tests if a high-dose nicotine patch worn before and after lung surgery can reduce pain in men who smoke but are quitting for the procedure. It aims to help manage pain during recovery.
Zhengzhou, HenanAges 18–75 - NCT06885970Recruiting
Cytisine for smoking cessation and heart health
This study tests whether a medicine called cytisine can help people quit smoking and how it might affect their heart health. If you are a smoker without serious heart, liver, kidney, or immune problems, you may be able to join.
Athens, HaidariAges 18–75 - NCT07215923RecruitingPhase 1
Study of ATI-1013 in healthy smokers who want to quit
This trial tests a new drug called ATI-1013 in healthy smokers. It aims to see how safe the drug is and how it works in the body. If you smoke at least 10 cigarettes a day and are in good health, you might be able to join.
Overland Park, KansasAges 23–59
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Common questions
- Are there clinical trials for smokers?
- Yes. Clin2 currently lists 54 recruiting smokers studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a smokers trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a smokers trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.