Clinical trials
Smokers clinical trials
Below are recruiting smokers clinical trials, each written for real people, not researchers. We’re tracking 59 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05121051RecruitingPhase 2
Broccoli sprout extract to reduce tobacco cancer-causing chemicals
This Phase 2 study tests whether broccoli sprout extract (Avmacol ES) can reduce cancer-causing substances linked to heavy smoking. It’s for adults who smoke heavily and may help lower harmful tobacco-related chemical effects in the body.
Tucson, ArizonaAges 18 years+ - NCT04281979Recruiting
Testing a substance’s effects in adult cigarette and vape users
This study tests how a specific substance affects people who currently smoke cigarettes or e-cigarettes. You may be able to join if you’re within a certain age range and recently had specific smoking and drinking patterns, and if you meet health/safety requirements for study procedures like MRI.
Portland, OregonAges 21–40 - NCT06595459RecruitingPhase 4
Options 2 study: testing nicotine replacement or medicines to help smokers switch
This study compares different nicotine replacement options to help people who smoke switch away from cigarettes. It may be a good fit if you smoke at least 5 cigarettes a day, aren't ready to quit in the next month, and are willing to stop using other stop-smoking aids.
Madison, WisconsinAges 21 years+ - NCT06537479Recruiting
Breathing technique and chest exercises for smokers' lung health
This trial tests if combining a special breathing method (Buteyko) with chest exercises can improve lung function and quality of life in current or long-term smokers aged 40-55. It may help if your breathing tests show reduced lung capacity.
Lahore, Punjab ProvinceAges 40–55 - NCT06444971Recruiting
Muscle relaxation for better lung function in smokers
This study tests a simple muscle relaxation technique to see if it improves how well your lungs work and how easily you breathe. If you are a smoker, this may help you understand more about your lung health.
Rawalpindi, Punjab ProvinceAges 18–60 - NCT07520981Recruiting
How Smoking Affects Fitness, Breathing, and Energy in Young Adults
This study measures how smoking affects your ability to exercise, your shortness of breath, and tiredness. Researchers will ask you to do some physical tests and answer questions about how you feel—it may help us understand smoking's impact on young people's health.
IstanbulAges 18–30 - NCT06763536Recruiting
Comparing nicotine pouches vs. nicotine patches or gum to help smokers in rural Appalachia quit
This study tests if oral nicotine pouches work better than nicotine patches or gum to help you smoke less. You’ll use one of these products for a while and check in with the study team. This is for adults who live in rural Appalachian counties and smoke at least 5 cigarettes a day.
Columbus, OhioAges 21 years+ - NCT07710820Recruiting
Can a heated tobacco product help you stop smoking?
This study tests whether having access to a heated tobacco product (a device that heats tobacco, not burns it) helps current cigarette smokers quit smoking. You'll try four different flavors over a week and then continue using one you like.
Brandon, FloridaAges 21–65 - NCT06264154Recruiting
Can e-cigarette flavor help you quit smoking?
This study looks at whether the flavor of an e-cigarette can help people who keep smoking switch completely away from regular cigarettes. Participants will use e-cigarettes with different flavors for 6 weeks.
Philadelphia, PennsylvaniaAges 21 years+ - NCT07455513Recruiting
Smoking cessation help for people with lung cancer
This study tests a new resource to help smokers who have or may have lung cancer quit smoking. The goal is to see if this resource makes it easier to stop smoking.
Columbus, OhioAges 21 years+ - NCT06988644Recruiting
Smoking cessation support for health workers
This study offers counseling at work to help health professionals quit smoking. It tests whether talking with a counselor at your workplace makes it easier to stop smoking for good.
Grenoble, isereAges 18 years+ - NCT07390695Enrolling by invitation
Gamified exercise for hardcore smokers who are inactive
This trial tests if a fun, game-like exercise program can help heavy smokers who don't exercise much improve their heart and lung fitness and feel more ready to quit smoking.
Yogyakarta, Special Region of YogyakartaAges 17–45 - NCT06885970Recruiting
Cytisine for smoking cessation and heart health
This study tests whether a medicine called cytisine can help people quit smoking and how it might affect their heart health. If you are a smoker without serious heart, liver, kidney, or immune problems, you may be able to join.
Athens, HaidariAges 18–75 - NCT04616313Recruiting
MRI and breathing tests in people who vape
This study uses a special lung scan (MRI) and breathing tests to understand how vaping affects lung structure and function. It may help researchers learn what early lung changes happen after starting vaping, even if you don’t feel sick.
London, OntarioAges 16 years+ - NCT06582693Recruiting
Tobacco treatment for families through children's hospital
This study offers proactive, personalized help to stop smoking for adults who smoke and have a child who is a patient at Children's Hospital of Philadelphia. It aims to see if this approach works better than usual care.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07598136Recruiting
How e-cigarette flavors affect smoking habits
This study looks at whether different flavors in e-cigarettes help smokers quit or reduce regular cigarettes. You'll use e-cigarettes with different flavors while researchers track your smoking habits through a smartphone app.
Maitland, FloridaAges 21–65 - NCT06156527RecruitingPhase 2
Lazertinib alone vs lazertinib plus Avastin for EGFR+ lung cancer in smokers
This trial tests if adding bevacizumab (Avastin) to lazertinib works better than lazertinib alone for advanced non-small cell lung cancer with an EGFR mutation. It is for people who have smoked at least 100 cigarettes in their lifetime.
Suwon, Gyeonggi-doAges 19 years+ - NCT04163081Recruiting
Help to quit smoking started from the emergency department
This study tests a program to help people who smoke quit, beginning when they are seen in the emergency department. It aims to see if starting nicotine-cessation support right away improves quitting over the next year.
Ottawa, OntarioAges 18 years+ - NCT04252781Recruiting
Study for people with new or suspected COPD risk
This study follows people who currently smoke and people who may have newly found COPD (chronic obstructive lung disease) based on breathing test results. It aims to better understand lung disease in real life and what it means for health over time.
Créteil, Île-de-France RegionAges 35 years+ - NCT04595422Recruiting
Train quitline staff to reach smokers about lung screening
This trial tests an educational approach delivered through tobacco quitlines to encourage eligible smokers to learn about lung cancer screening. It may help people who have a heavy smoking history get the right information and next steps.
Houston, TexasAges 18 years+ - NCT04722835Recruiting
Study lung immune cells in people at risk for COPD
This study looks at different lung immune cell patterns and how they work in smokers who are not yet diagnosed with COPD or asthma. It may help researchers understand why some people are more likely to develop COPD, which could guide future prevention or early treatments.
San Francisco, CaliforniaAges 40–75 - NCT05456256RecruitingPhase 2
LP-300 plus chemo for lung cancer in never-smokers
This Phase 2 trial tests LP-300 with carboplatin and pemetrexed to treat advanced lung adenocarcinoma in people who have never smoked. It may help shrink tumors and slow the disease in a specific genetic group of lung cancer.
Beverly Hills, CaliforniaAges 18 years+ - NCT05643469Recruiting
Instant messaging support to help smokers quit during cancer treatment
This trial tests a quit-smoking support program using instant messages to help smokers stop smoking while they have cancer. It may help you reduce smoking cravings and stay engaged in quitting support.
Hong KongAges 18 years+ - NCT05722561RecruitingPhase 2
E-cigarettes to reduce smoking in opioid use disorder
This Phase 2 study tests whether e-cigarettes can help people who use opioids (and also smoke cigarettes) cut down on combustible cigarette smoking. It looks at whether switching to e-cigarettes for “harm reduction” is safe and helps you smoke fewer cigarettes without requiring you to quit completely.
New York, New YorkAges 21–75
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Common questions
- Are there clinical trials for smokers?
- Yes. Clin2 currently lists 59 recruiting smokers studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a smokers trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a smokers trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.