Clinical trials
Substance Abuse Disorder clinical trials
Below are recruiting substance abuse disorder clinical trials, each written for real people, not researchers. We’re tracking 53 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06548490RecruitingPhase 2
Semaglutide for Opioid Use Disorder
This study tests whether a once-weekly injection of semaglutide (a GLP-1 receptor agonist) can reduce opioid use in people who are already on buprenorphine or methadone but still using opioids. It lasts about 19 weeks.
Baltimore, MarylandAges 18–75 - NCT04141202Recruiting
Exercise program during short inpatient treatment for substance use
This trial tests a structured exercise program for people receiving short-term inpatient treatment for substance use. It may help improve health and recovery support during your stay.
TrondheimAges 18 years+ - NCT06880705Recruiting
Trans-Led Care Study for alcohol and drug support
This study is testing a program designed by and for transgender adults to help with alcohol or drug use problems. It looks at whether a supportive, community-based approach can improve health and well-being.
Chicago, IllinoisAges 18 years+ - NCT07692984Recruiting
Alcohol and drug use in people with schizophrenia or bipolar disorder
This study looks at how alcohol and substance use affects people with schizophrenia or bipolar disorder. It aims to understand if having these conditions together changes treatment or outcomes.
Bolu, BoluAges 18–65 - NCT06065553Recruiting
Prevalence of mental health issues in homeless or precarious people in Cayenne
This study looks at how common mental health and substance use problems are among people in difficult living situations in Cayenne. Understanding this can help create better support services.
CayenneAges 18–99 - NCT06262958Recruiting
Early help for teen alcohol and substance issues
This study looks at early help for alcohol and substance use in teenagers. The goal is to see if early support can improve outcomes for young people who have been treated at a psychiatric clinic.
KuopioAges 14–19 - NCT06413979Recruiting
Family support program for teens with substance use and mood or anxiety issues
This trial offers a family support program for teens with both substance use and internalizing problems like depression or anxiety. The goal is to help you and your caregiver work together to manage symptoms and improve well-being.
Jacksonville, FloridaAges 13–21 - NCT06788587RecruitingPhase 2
Long-term stimulant for methamphetamine recovery
This study tests whether a high dose of a stimulant medication (lisdexamfetamine, an ADHD medicine) taken over many weeks can help people who have already completed a methamphetamine treatment program to stay off meth, reduce use, or avoid relapse.
Montreal, QuebecAges 18–55 - NCT06856148Recruiting
Improving substance misuse prevention research use in state policy
This study aims to better share research on preventing substance misuse with state policymakers. It is for state-level public officials who help make or influence policy.
University Park, PennsylvaniaAges Any age - NCT06961838Recruiting
Breathing muscle training for substance use recovery
This study tests whether a breathing exercise device can help people recovering from substance use disorder. It may improve how well your breathing muscles work and support your overall treatment.
Istanbul, TurkeyAges 18 years+ - NCT07281261Recruiting
Nerve stimulation for alcohol use disorder
This study tests whether a mild nerve stimulation device (tAN) can help reduce alcohol cravings and withdrawal. It's for people with moderate to severe alcohol use disorder who are going through withdrawal and do not use tobacco.
Houston, TexasAges 18–64 - NCT07340554Recruiting
Brain imaging study for teens who use cannabis
This study looks at the brains of teenagers who use cannabis using an MRI scanner. It aims to understand how cannabis affects the developing brain, which might help improve treatment options.
Indianapolis, IndianaAges 14–17 - NCT06743282Enrolling by invitation
Study on mobile support for substance use in primary care
This trial tests a program called Senyo Health that provides support through text messages and video calls for people with substance use concerns. It aims to help you manage your substance use while working with your primary care doctor.
Scottsdale, ArizonaAges 18 years+ - NCT06837662Recruiting
Counseling and peer support for opioid use disorder in primary care
This study tests whether adding counseling and peer support helps people with opioid use disorder and other medical problems stay in treatment. It is for patients seen at Central City Concern in Portland who are starting or restarting medication for opioid use disorder, or who are not yet on medication but want help.
Portland, OregonAges 18 years+ - NCT06899308Recruiting
Health check for university students
This study checks the health of students at two universities in Germany. It uses online surveys and interviews to monitor well-being over time.
BremenAges 18 years+ - NCT07417280Recruiting
Focused ultrasound for neurological disorders
This trial tests a gentle ultrasound treatment (LIFUS) for people with various brain conditions like epilepsy, tumours, or movement disorders. It aims to see if this non-invasive approach can help where other treatments are being used.
Toronto, OntarioAges 18–85 - NCT03906435Recruiting
Cognitive therapy to prevent problems for very premature NICU babies
This study offers a counseling approach to help prevent “Vulnerable Child Syndrome” in babies born very early and cared for in the NICU. It focuses on support during the early months after birth and compares outcomes for families getting the therapy versus usual support.
Dallas, TexasAges Any age - NCT07652645Recruiting
DBT therapy for veterans with war-related PTSD
This trial tests a special type of therapy (Dialectical Behavior Therapy, or DBT) adapted for veterans with PTSD from war. It uses a mix of online sessions and homework to help you control emotions and reduce trauma symptoms.
Amstelveen, North HollandAges 18 years+ - NCT05538910Recruiting
Study brain links between depression and substance use
This study uses brain imaging and questionnaires to understand how substance use and depression are connected in the brain. It may help researchers identify biological patterns that could guide better treatments in the future.
Baltimore, MarylandAges 18–60 - NCT06852170Recruiting
Data-driven decisions for substance use services
This trial helps decision-makers use data to improve substance use services and prevent overdoses. It is for professionals who shape policy or run programs in behavioral health, public health, law enforcement, or advocacy.
Eugene, OregonAges 18 years+ - NCT06552741Recruiting
Screening for substance and alcohol use studies
This study screens people with or without past or current substance or alcohol use problems. It helps the researchers see if you might qualify for other studies at the NIDA research center.
Baltimore, MarylandAges 18–99 - NCT04294134Enrolling by invitation
Support program for mothers in residential substance treatment
This trial tests a support program for mothers (pregnant or with young children) who are in residential substance use treatment. It aims to improve well-being, family stability, and child safety—especially when children are at risk or in out-of-home placement.
Philadelphia, PennsylvaniaAges Any age - NCT07665502Enrolling by invitation
Smartphone app to boost opioid treatment for women facing violence
This study tests a smartphone app (WINGS+++) to help women who have experienced intimate partner violence and trauma improve their engagement with medication for opioid use disorder (MOUD). The goal is to see if the app makes it easier to start and stay on treatment.
New York, New YorkAges 18 years+ - NCT04927143Recruiting
Using phone incentives to support substance abstinence
This study tests a smartphone app that gives changing rewards to help people avoid drug use. It targets adults in substance treatment and tries to see if incentives can improve abstinence during treatment.
Oconomowoc, WisconsinAges 18 years+
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Common questions
- Are there clinical trials for substance abuse disorder?
- Yes. Clin2 currently lists 53 recruiting substance abuse disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a substance abuse disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a substance abuse disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.