Clinical trials
Supplementation clinical trials
Below are recruiting supplementation clinical trials, each written for real people, not researchers. We’re tracking 697 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04677816RecruitingPhase 2
Vitamin D supplements for triple-negative breast cancer before surgery
This trial tests whether taking high-dose vitamin D during pre-surgery (neoadjuvant) chemotherapy can increase the chance of having no remaining cancer found at surgery. It focuses on people with vitamin D deficiency and triple-negative breast cancer.
Winston-Salem, North CarolinaAges 18 years+ - NCT04700527RecruitingPhase 1/Phase 2
SCFA supplements during belly/pelvis radiation for cancer
This early-phase study tests whether an SCFA (fatty-acid) supplement can improve how patients tolerate radiation to the abdomen or pelvis. Participants are randomly assigned to receive the supplement or a comparison treatment, while they receive their planned radiation.
Chapel Hill, North CarolinaAges 18 years+ - NCT04732962Recruiting
Special shoes to help knee osteoarthritis symptoms without surgery
This study tests whether custom biomechanical footwear can reduce pain and improve function in people with knee osteoarthritis. It may help as a non-surgical option to ease symptoms while you’re considering or preparing for care.
Danville, PennsylvaniaAges 45–80 - NCT04775381RecruitingPhase 3
Vitamin D before thyroid surgery to prevent low calcium
This study tests whether taking vitamin D (cholecalciferol) before a total thyroid removal can reduce the risk of developing low blood calcium afterward. If you’re having your thyroid removed, the results may help prevent symptoms like tingling, cramps, or spasms caused by low calcium.
AuxerreAges 18 years+ - NCT04858412Recruiting
Amino acid supplement to help people with COVID-19 and alcohol liver disease
This study tests whether an HMB-enriched amino acid supplement can improve outcomes in adults who have COVID-19 pneumonia, especially those with alcohol-related liver disease. The trial compares results in people with alcohol liver disease versus those without, to see if the supplement helps during recovery.
Cleveland, OhioAges 21 years+ - NCT04868578Recruiting
Vitamin PPI supplements for ectopic calcification in PXE
This trial studies whether taking PPI-type supplements can slow or reduce unwanted calcification in people with PXE. It’s meant to help manage disease changes caused by abnormal calcium deposits, based on your medical testing.
AngersAges 18–65 - NCT04926597Recruiting
Extra nutrition after hospital discharge for higher-risk patients
This study looks at whether continuing nutritional support after you leave the hospital can reduce death risk and help you recover better—like improving strength, frailty, and daily functioning. It targets people who are at higher risk of poor nutrition during/after their hospital stay.
BarcelonaAges 18 years+ - NCT04944836RecruitingPhase 2
Testosterone supplement with rotator cuff repair
This study tests whether taking a sex hormone (testosterone) around the time of rotator cuff surgery improves healing after repair. It may help some men recover better, but it only fits people with specific tear features and health conditions.
Salt Lake City, UtahAges 40–80 - NCT04949451Recruiting
Testing time-restricted eating for muscle and metabolism
This study looks at whether eating only during certain hours can improve muscle and metabolism in adults with higher body weight. You may be asked to follow a specific eating schedule and avoid things that could affect the results.
Fayetteville, ArkansasAges 25–50 - NCT04959864Recruiting
Food supplement study for sperm DNA damage in men
This trial tests whether a daily food supplement (with myo-inositol, N-acetyl-cysteine, zinc, and vitamins) can reduce sperm DNA damage. It enrolls men with higher-than-normal sperm DNA fragmentation, and it checks semen health during the study.
ParisAges 20–45 - NCT05031364Recruiting
CBT skills coaching for youth with autism and emotional needs
This study tests a therapy program (called CBT) that helps children with autism who also struggle with emotional or behavioral regulation. It aims to reduce emotional outbursts and improve coping while receiving care through community providers.
Culver City, CaliforniaAges 6–14 - NCT05040204RecruitingPhase 1
Test supplements to change how sugars attach to blood proteins
This early (Phase 1) study tests how adding specific dietary supplements affects “protein glycosylation,” which means how sugar molecules attach to proteins in your blood. It’s meant to see how the supplements change these blood measurements and whether the approach is tolerable in generally healthy adults.
Sacramento, CaliforniaAges 18–45 - NCT05043116RecruitingPhase 2
Vitamin D for preventing asthma-like flare-ups in young children
This study tests whether a high-dose vitamin D supplement can help preschool children have fewer acute asthma-like symptoms (coughing, wheezing, or trouble breathing) that require hospital care. It may help by supporting the immune and airway system, but you can only join if the child meets several safety and treatment criteria.
Gentofte Municipality, GentofteAges 1 year–5.9 years - NCT05067998Recruiting
Natural medicine and vitamin IV study for overall health
This study looks at whether natural medicine, vitamin IV fluids, and supplements can help people maintain good health. There don’t appear to be specific eligibility limits listed, so many people may be able to join, but you’d still need screening by the study team.
Dover, DelawareAges 21–80 - NCT05095571Recruiting
Extension study of vitamin supplements for ALS
This study looks at continuing a nicotinamide/pterostilbene supplement in people with ALS who already finished an earlier related NO-ALS study. It may help researchers learn whether the supplement can be continued safely and potentially benefit longer-term outcomes.
BergenAges 35 years+ - NCT05112328Recruiting
Pancreatic enzyme added to feeding for ICU adults
This study tests whether adding pancreatic digestive enzymes to tube feeding can improve digestion and outcomes in critically ill adults who have higher risk of not producing enough digestive enzymes. If you qualify, you may receive the enzyme supplement or a comparison treatment while you’re in the ICU.
Seoul, Jongno-guAges 18 years+ - NCT05178069RecruitingPhase 2
Probiotic supplement study for alcohol use disorder and liver injury
This Phase 2 trial studies whether a probiotic (LGG) can improve health in people with alcohol use disorder and alcohol-related liver injury. It’s not an alcohol treatment study, so participants are mainly joining to see how the supplement affects the body and liver-related outcomes.
Louisville, KentuckyAges 21–65 - NCT05194397RecruitingPhase 2
Exercise plus NR supplement to boost fitness after stem-cell transplant
This trial tests whether a supervised exercise program, plus an NR supplement, can improve fitness in young people who have had an allogeneic (donor) stem-cell transplant for certain blood cancers or bone marrow conditions. It’s meant to help with energy and physical ability while monitoring safety.
Duarte, CaliforniaAges 10–30 - NCT05196763Recruiting
Nutrition lessons for Indiana families on SNAP-Ed timing
This study tests nutrition education for families with children who receive SNAP (food assistance). It aims to see how to better support food security and healthy eating by planning SNAP-Ed lessons and participation over about one year.
West Lafayette, IndianaAges 5 years+ - NCT05212454RecruitingPhase 3
Capecitabine added after surgery for high-risk ER-positive breast cancer
This Phase 3 study tests whether adding capecitabine (a chemotherapy pill) after breast cancer surgery can lower the chance the cancer comes back. It targets people with hormone-receptor–positive and HER2-negative breast cancer who are considered “high risk.”
Hanzhou, ZhejiangAges 18–70 - NCT05228860Recruiting
Nutrition support program for adults with type 2 diabetes
This trial tests whether improving access to healthy food can help adults with type 2 diabetes—especially people dealing with food insecurity. It also includes a family member who helps support healthy eating at home.
Concord, CaliforniaAges 18 years+ - NCT05259904RecruitingPhase 2
L-citrulline supplement for deployment-related asthma symptoms
This trial studies whether an L-citrulline supplement can improve asthma control in people who developed persistent asthma symptoms after military deployment. If you qualify, you may be asked to track symptoms and breathing test results to see if the supplement helps.
Denver, ColoradoAges 18–70 - NCT05294367RecruitingEarly Phase 1
Magnesium by diet or skin lotion for people with lymphoma
This early study tests whether replacing magnesium—either by diet or a topical (skin) supplement—can improve safety or other health measures in people with lymphoma. It focuses on people who have a slightly low magnesium level and checks blood magnesium repeatedly during the study.
Rochester, MinnesotaAges 18 years+ - NCT05306925Recruiting
Arginine supplement study for newborns after major gut surgery
This study looks at whether giving an amino-acid supplement called arginine to newborns after major bowel surgery can improve the baby’s immune response. It may help doctors understand how to support recovery after conditions like necrotizing enterocolitis or certain birth defects.
Liverpool, MerseysideAges 5 months–10 months
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Common questions
- Are there clinical trials for supplementation?
- Yes. Clin2 currently lists 697 recruiting supplementation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a supplementation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a supplementation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.