Treatment
Metformin clinical trials
We’re tracking 148 recruiting studies that include Metformin, each written for real people, not researchers, below.
Recruiting studies
- NCT07293325Recruiting
Semaglutide and Tirzepatide for slowing aging in adults with obesity
This trial tests if two newer weight-loss medications, semaglutide and tirzepatide, can help slow the aging process in adults with obesity. It compares the drugs to each other and to a placebo to see which might offer anti-aging benefits beyond weight loss.
HangzhouAges 18–75 - NCT07280572Enrolling by invitationPhase 3
Platform trial of treatments for long COVID
This trial tests different treatments for long COVID (PCC) symptoms like fatigue and brain fog that started after a COVID infection. It aims to find which treatments help people recover.
UtrechtAges 18 years+ - NCT07254572RecruitingPhase 4
Comparing diabetes drugs for heart health in prediabetes
This trial tests whether certain diabetes medications can help prevent worsening of heart disease in people who have prediabetes (higher than normal blood sugar, but not yet diabetes). It may be a good fit if you have known coronary artery disease and prediabetes.
WarsawAges 18–80 - NCT07244003RecruitingPhase 4
Testing metformin with two newer diabetes drugs
This trial is testing if adding a combination of SGLT-2 inhibitor and GLP-1 receptor agonist to metformin can improve blood sugar control in people with type 2 diabetes who are not meeting their goals on metformin alone or with one other pill.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07244575Recruiting
Metformin and nausea after general anesthesia study
This study looks at whether the diabetes medicine metformin, taken before surgery, affects the risk of nausea and vomiting after general anesthesia. If you take metformin and are having planned surgery, this trial may help understand its effects.
Guangzhou, GuangdongAges 18 years+ - NCT07182526RecruitingPhase 2
Quercetin or alpha lipoic acid for PCOS symptoms
This trial tests adding quercetin or alpha lipoic acid to standard PCOS care to see if they improve symptoms and blood markers. It may help women who have irregular periods or signs of excess androgens like acne.
Baghdad, KarkhAges 18 years+ - NCT07109700RecruitingPhase 2
New injectable study for type 2 diabetes
This study tests a new once-weekly injectable medication (HDM1005) for people with type 2 diabetes whose blood sugar is not well controlled by diet and exercise or metformin alone. It aims to help lower blood sugar and may also support weight loss.
Beijing, Beijing MunicipalityAges 18–65 - NCT07092618RecruitingPhase 2/Phase 3
Trial for keeping weight off after stopping GLP-1 meds
This study tests if other medicines (naltrexone, metformin, or rapamycin) can help people keep off weight they lost while taking GLP-1 drugs like Wegovy or Ozempic, after they stop taking them. It is for AgelessRx patients aged 40 to 85 who have lost at least 15 pounds on GLP-1s.
Chicago, IllinoisAges 40–85 - NCT07083388RecruitingPhase 1
Study of how different forms of BR3006 work in healthy adults
This trial tests how the body processes different forms of a drug called BR3006 in healthy volunteers. It compares a single tablet (BR3006) to a combination of three separate components (BR3006A, BR3006B, and BR3006C) given together. This helps researchers understand if the combination works the same as the single tablet.
Seoul, Gwanak-guAges 19 years+ - NCT07083401RecruitingPhase 1
Study of a New Drug Combination in Healthy Adults
This trial tests how a new combination of drugs (BR3006A, BR3006B, and BR3006C) is absorbed and processed by the body when taken together, compared to a single tablet (BR3006). It is for healthy adults to understand the safety and behavior of the medication.
Seoul, Gwanak-guAges 19 years+ - NCT07065591RecruitingEarly Phase 1
Metformin, Exercise, and Diet for Knee Osteoarthritis
This trial tests whether a common diabetes drug (metformin) combined with exercise and a healthy diet can help people with knee osteoarthritis who are overweight.
Hong Kong, Sandy BayAges 40–80 - NCT07001878RecruitingPhase 4
Cannabis Strength and Brain Health in Early Psychosis
This trial studies how different strengths of cannabis affect the brain's white matter in people with early psychosis. It may help doctors understand which cannabis potencies are less harmful for young adults with psychosis.
St. John's, Newfoundland and LabradorAges 18–25 - NCT06975111RecruitingPhase 2/Phase 3
Improving health during menopause
This trial studies ways to help women during the late menopausal transition. It uses a smartphone app and telehealth visits to track your health and help you feel better.
Aurora, ColoradoAges 45–55 - NCT06959784Enrolling by invitationPhase 4
A study on new diabetes drugs for heart health and remission
This trial tests if newer diabetes medications can reduce heart risk and help achieve diabetes remission in people newly diagnosed with type 2 diabetes. It may be an option if you have not taken diabetes drugs before or stopped them over three months ago, and your blood sugar and weight are in certain ranges.
BeijingAges 30–70 - NCT06889454Recruiting
Heart and blood vessel changes in women with PCOS after treatment
This trial looks at how the heart's blood vessels and certain markers change in women with PCOS when they drink a sugary solution (OGTT). It checks these markers before treatment starts and again 6 and 12 months after, to help understand cardiovascular risk in PCOS.
ChaïdáriAges 18–45 - NCT06836128RecruitingPhase 3
N-Acetyl Cysteine and Metformin for PCOS
This trial tests whether adding N-acetyl cysteine (NAC) to metformin helps women with PCOS more than metformin alone. It might be a good fit if you have PCOS, are between 20 and 45, and don't have other health issues like diabetes or thyroid problems.
CairoAges 20–45 - NCT06666933Enrolling by invitation
Time-restricted eating for PCOS with glucose issues during IVF
This study tests whether a time-restricted eating plan (eating only during certain hours of the day) can improve pregnancy rates in women with PCOS and glucose metabolism problems who are undergoing IVF. The goal is to see if this eating pattern helps your body respond better to treatment.
Shanghai, Shanghai MunicipalityAges 20–38 - NCT06446531RecruitingPhase 1
Preventing diabetes progression in Hispanic adults
This trial tests if a medication can prevent or slow the progression from prediabetes to type 2 diabetes and reduce heart risk. It is for Hispanic adults who are overweight and have prediabetes.
San Antonio, TexasAges 18 years+ - NCT06246799RecruitingPhase 3
Comparing two pill combinations for new diabetes
This study compares two different two-drug combinations for people recently diagnosed with type 2 diabetes. It aims to find which combination works better to control blood sugar and improve overall health.
San Antonio, TexasAges 18–75 - NCT06044025RecruitingPhase 1
Maintenance therapy for prostate cancer with rising PSA
This trial tests two medications (metformin and a turmeric compound) as a maintenance therapy for men with prostate cancer whose PSA is rising slowly after prior treatment. The goal is to see if these drugs can keep the cancer from growing while you take a break from standard hormone therapy.
Little Rock, ArkansasAges 18–100 - NCT05768139RecruitingPhase 1/Phase 2
Testing a new targeted drug for advanced solid tumors with PI3Kα mutation
This trial tests tersolisib, a new targeted medicine, in adults with advanced or hard-to-remove solid cancers. It focuses on tumors that have a specific genetic change (PI3Kα mutation) to see how well the treatment works and what side effects it causes.
Los Angeles, CaliforniaAges 18 years+ - NCT05164263RecruitingPhase 4
Testing empagliflozin for adults with type 2 diabetes on tablets
This study looks at how well and how safely empagliflozin works in real-world care for adults with type 2 diabetes who are not controlled on current pill treatment. Some participants take it with metformin, and the study helps confirm what to expect in everyday patients.
Kabul, AfghanistanAges 18–65 - NCT05041907RecruitingPhase 2
Testing an antiviral’s effects in early COVID-19
This trial looks at how well an antiviral works in the body when started early in people with COVID-19 symptoms. You may be able to join if you’re an otherwise healthy adult with confirmed infection and symptoms for less than 4 days.
Minas GeraisAges 18–60 - NCT04114136RecruitingPhase 2
Study tests pembrolizumab or nivolumab plus a diabetes-like drug
This Phase 2 study tests whether adding a metabolic (diabetes-related) medicine to an immune therapy (pembrolizumab or nivolumab) can better control certain solid tumors. It may help people whose standard treatment would usually be pembrolizumab or nivolumab alone.
Pittsburgh, PennsylvaniaAges 18 years+
Common questions
- Are there clinical trials studying Metformin?
- Yes. Clin2 currently lists 148 recruiting studies that include Metformin, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Metformin trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Metformin an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Metformin or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.