Treatment
Metformin clinical trials
We’re tracking 152 recruiting studies that include Metformin, each written for real people, not researchers, below.
Recruiting studies
- NCT02969798Recruiting
Study of prediabetes with abnormal sugars and medicines
This study looks at adults with prediabetes—specifically abnormal fasting and/or 2-hour blood sugar tests—to see whether a treatment helps improve sugar control. You may also be compared with people who have normal blood sugar (the control group).
San Antonio, TexasAges 18–65 - NCT07588932RecruitingEarly Phase 1
Medication and Robot Training for Stroke Arm Recovery
This study tests whether three medications (Telmisartan, Cilostazol, and Metformin) combined with robotic arm training can help people improve arm movement and strength after a chronic stroke. You would participate in supervised training sessions using a robotic rehabilitation system.
Charlestown, MassachusettsAges 21–80 - NCT04114136RecruitingPhase 2
Study tests pembrolizumab or nivolumab plus a diabetes-like drug
This Phase 2 study tests whether adding a metabolic (diabetes-related) medicine to an immune therapy (pembrolizumab or nivolumab) can better control certain solid tumors. It may help people whose standard treatment would usually be pembrolizumab or nivolumab alone.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05041907RecruitingPhase 2
Testing an antiviral’s effects in early COVID-19
This trial looks at how well an antiviral works in the body when started early in people with COVID-19 symptoms. You may be able to join if you’re an otherwise healthy adult with confirmed infection and symptoms for less than 4 days.
Minas GeraisAges 18–60 - NCT05164263RecruitingPhase 4
Testing empagliflozin for adults with type 2 diabetes on tablets
This study looks at how well and how safely empagliflozin works in real-world care for adults with type 2 diabetes who are not controlled on current pill treatment. Some participants take it with metformin, and the study helps confirm what to expect in everyday patients.
Kabul, AfghanistanAges 18–65 - NCT05345327RecruitingPhase 3
First diabetes pill to protect kidneys
This Phase 3 trial tests whether starting a diabetes medicine called dapagliflozin can better slow kidney damage than starting metformin in adults with type 2 diabetes. It may help preserve kidney function over time and reduce future kidney decline.
Sydney, New South WalesAges 18 years+ - NCT05768139RecruitingPhase 1/Phase 2
Testing a new targeted drug for advanced solid tumors with PI3Kα mutation
This trial tests tersolisib, a new targeted medicine, in adults with advanced or hard-to-remove solid cancers. It focuses on tumors that have a specific genetic change (PI3Kα mutation) to see how well the treatment works and what side effects it causes.
Los Angeles, CaliforniaAges 18 years+ - NCT06096259RecruitingPhase 2
Preventing knee arthritis after ACL injury
This trial tests whether metformin, a common diabetes medicine, can prevent arthritis after an ACL injury. If you are planning to have ACL surgery soon, you may be able to join.
Atlanta, GeorgiaAges 18–45 - NCT06246799RecruitingPhase 3
Comparing two pill combinations for new diabetes
This study compares two different two-drug combinations for people recently diagnosed with type 2 diabetes. It aims to find which combination works better to control blood sugar and improve overall health.
San Antonio, TexasAges 18–75 - NCT06446531RecruitingPhase 1
Preventing diabetes progression in Hispanic adults
This trial tests if a medication can prevent or slow the progression from prediabetes to type 2 diabetes and reduce heart risk. It is for Hispanic adults who are overweight and have prediabetes.
San Antonio, TexasAges 18 years+ - NCT06515652Recruiting
Herbal vs standard medicines for metabolic syndrome
This study compares herbal medicines to standard medications for people with metabolic syndrome—a group of conditions like high blood pressure, high blood sugar, and excess belly fat. The goal is to see if herbs work as well as traditional drugs, with fewer side effects.
Karachi, SindhAges 35–65 - NCT06836128RecruitingPhase 3
N-Acetyl Cysteine and Metformin for PCOS
This trial tests whether adding N-acetyl cysteine (NAC) to metformin helps women with PCOS more than metformin alone. It might be a good fit if you have PCOS, are between 20 and 45, and don't have other health issues like diabetes or thyroid problems.
CairoAges 20–45 - NCT06846411RecruitingPhase 4
Empagliflozin in newly untreated type 2 diabetes
This trial tests a medication called empagliflozin (a type 2 diabetes pill) to see how well it works in people with type 2 diabetes who have not taken any diabetes drugs for at least 8 weeks. If you qualify, you may receive the study drug and help researchers learn more about managing blood sugar.
SeongnamAges 20 years+ - NCT06889454Recruiting
Heart and blood vessel changes in women with PCOS after treatment
This trial looks at how the heart's blood vessels and certain markers change in women with PCOS when they drink a sugary solution (OGTT). It checks these markers before treatment starts and again 6 and 12 months after, to help understand cardiovascular risk in PCOS.
ChaïdáriAges 18–45 - NCT06896981RecruitingPhase 2/Phase 3
Semaglutide for women with PCOS and obesity
This study tests if a weekly injection called semaglutide can help women with PCOS and obesity lose weight and improve their health. It is for women who do not have other serious medical conditions.
Dhaka, Dhaka DivisionAges 10–45 - NCT07001878RecruitingPhase 4
Cannabis Strength and Brain Health in Early Psychosis
This trial studies how different strengths of cannabis affect the brain's white matter in people with early psychosis. It may help doctors understand which cannabis potencies are less harmful for young adults with psychosis.
St. John's, Newfoundland and LabradorAges 18–25 - NCT07083388RecruitingPhase 1
Study of how different forms of BR3006 work in healthy adults
This trial tests how the body processes different forms of a drug called BR3006 in healthy volunteers. It compares a single tablet (BR3006) to a combination of three separate components (BR3006A, BR3006B, and BR3006C) given together. This helps researchers understand if the combination works the same as the single tablet.
Seoul, Gwanak-guAges 19 years+ - NCT07083401RecruitingPhase 1
Study of a New Drug Combination in Healthy Adults
This trial tests how a new combination of drugs (BR3006A, BR3006B, and BR3006C) is absorbed and processed by the body when taken together, compared to a single tablet (BR3006). It is for healthy adults to understand the safety and behavior of the medication.
Seoul, Gwanak-guAges 19 years+ - NCT07109700RecruitingPhase 2
New injectable study for type 2 diabetes
This study tests a new once-weekly injectable medication (HDM1005) for people with type 2 diabetes whose blood sugar is not well controlled by diet and exercise or metformin alone. It aims to help lower blood sugar and may also support weight loss.
Beijing, Beijing MunicipalityAges 18–65 - NCT07182526RecruitingPhase 2
Quercetin or alpha lipoic acid for PCOS symptoms
This trial tests adding quercetin or alpha lipoic acid to standard PCOS care to see if they improve symptoms and blood markers. It may help women who have irregular periods or signs of excess androgens like acne.
Baghdad, KarkhAges 18 years+ - NCT07244003RecruitingPhase 4
Testing metformin with two newer diabetes drugs
This trial is testing if adding a combination of SGLT-2 inhibitor and GLP-1 receptor agonist to metformin can improve blood sugar control in people with type 2 diabetes who are not meeting their goals on metformin alone or with one other pill.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07254572RecruitingPhase 4
Comparing diabetes drugs for heart health in prediabetes
This trial tests whether certain diabetes medications can help prevent worsening of heart disease in people who have prediabetes (higher than normal blood sugar, but not yet diabetes). It may be a good fit if you have known coronary artery disease and prediabetes.
WarsawAges 18–80 - NCT07300293Recruiting
Metformin and lactic acidosis in intensive care
This study looks at patients in intensive care who had lactic acidosis, to see if taking metformin before admission played a role. It may help understand how metformin affects recovery.
StrasbourgAges 18 years+ - NCT07379333RecruitingPhase 3
Testing a new drug for type 2 diabetes when metformin and dapagliflozin aren't enough
This study tests a new medicine (HM11260C) to see if it helps people with type 2 diabetes who are already taking metformin and dapagliflozin but still have high blood sugar. If you qualify, it could give you a new option to better control your diabetes.
Gyeonggi-doAges 19 years+
Common questions
- Are there clinical trials studying Metformin?
- Yes. Clin2 currently lists 152 recruiting studies that include Metformin, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Metformin trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Metformin an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Metformin or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.