Treatment
Metformin clinical trials
We’re tracking 152 recruiting studies that include Metformin, each written for real people, not researchers, below.
Recruiting studies
- NCT07297290RecruitingPhase 3
Testing Metformin for Weight Loss in Obesity
This trial tests whether metformin, a common diabetes medicine, can help people with obesity lose weight. It is for people who do not have diabetes and have not used weight loss treatments in the past year.
Enugu, Enugu StateAges 20–59 - NCT07331389RecruitingPhase 1
How HDM1002 interacts with common drugs and diabetes medications
This study tests how a new drug called HDM1002 interacts with common diabetes medications (metformin, empagliflozin) and other drugs like warfarin and valsartan. If you are a generally healthy adult (age 18-45) with a higher BMI, this trial helps ensure the new drug is safe when taken with other medicines.
HefeiAges 18–45 - NCT07387900RecruitingPhase 2
Metformin for preventing cancer in oral leukoplakia
This study tests if metformin — a medication commonly used for diabetes — can prevent oral leukoplakia from turning into cancer when applied as a mouth rinse and taken as a pill. It is for people with non-severe white patches in the mouth.
CairoAges 21 years+ - NCT01638676RecruitingPhase 1/Phase 2
Testing vemurafenib plus metformin for BRAF-mutated melanoma
This study tests whether adding metformin to vemurafenib can shrink advanced melanoma in people with a specific gene change (BRAF V600E). It’s an early-phase trial, so the main goal is to see if the combination is safe and whether it may work better than expected.
Louisville, KentuckyAges 18 years+ - NCT02647827RecruitingPhase 2
Acupuncture or metformin for insulin resistance in PCOS
This study tests whether acupuncture or the diabetes medicine metformin can improve insulin resistance in women with PCOS. It may help with hormone-related symptoms and metabolic health, comparing the two approaches against usual care for non-PCOS controls.
BeijingAges 18–40 - NCT02947503RecruitingPhase 3
Metformin for gestational diabetes in pregnancy outcomes
This study tests whether taking metformin during pregnancy improves outcomes for people with gestational diabetes. It may help with pregnancy health and baby outcomes compared with the study’s other diabetes care plan.
GroningenAges 18–45 - NCT07659444Recruiting
Metformin withdrawal study for metabolic syndrome
This study looks at what happens when people with metabolic syndrome temporarily stop taking metformin. It aims to understand how their bodies respond when the medication is paused for 14 days.
Toledo, ToledoAges 18 years+ - NCT07179042Enrolling by invitationEarly Phase 1
Metformin for hip fracture recovery in older adults
This study tests whether the diabetes drug metformin can help older adults recover better after hip fracture surgery. To join, you need to be 60+, have had a low-energy hip fracture fixed within 3 days, and be generally healthy without diabetes or kidney issues.
Salt Lake City, UtahAges 60–90 - NCT06846138Enrolling by invitation
Herbal supplement to help metformin work better and cause fewer side effects
This study tests a special herbal blend added to metformin to see if it helps reduce stomach problems and improves blood sugar control in people with type 2 diabetes. Researchers want to understand how the herbs affect the bacteria in your gut.
RigaAges 25–80 - NCT06429007Enrolling by invitationPhase 1
Metformin for infants after brain injury from HIE
This trial tests whether metformin, a common diabetes medicine, can help heal brain injury in infants who had HIE (lack of oxygen at birth) and were treated with cooling. It aims to see if the drug is safe and possible to give to babies between 3 and 6 months old.
Boston, MassachusettsAges 3 months–6 months - NCT07760883Recruiting
Metformin response based on genetic variation in type 2 diabetes
This study looks at how your genes might affect the way your body responds to metformin, a common diabetes medication. It aims to see if a specific genetic variation influences treatment outcomes.
Mexico City, Mexico CityAges 18–65 - NCT03424005RecruitingPhase 1/Phase 2
Testing new drug combinations for advanced breast cancer
This study tests how well and how safely different combinations of cancer drugs work for people with metastatic or inoperable locally advanced breast cancer. It may help by finding a better treatment option and collecting information to guide future care.
Duarte, CaliforniaAges 18 years+ - NCT03511118Recruiting
Drug safety study for breastfeeding mothers and babies
This study measures how common medicines move through a breastfeeding parent’s milk and checks safety in both the parent and breastfed baby. It may help doctors use these medicines more safely while you continue breastfeeding.
La Jolla, CaliforniaAges Any age - NCT06975111RecruitingPhase 2/Phase 3
Improving health during menopause
This trial studies ways to help women during the late menopausal transition. It uses a smartphone app and telehealth visits to track your health and help you feel better.
Aurora, ColoradoAges 45–55 - NCT06318442Recruiting
Preventing steroid-induced diabetes with a GLP-1 drug
This study tests whether a GLP-1 medication (a type of drug that helps control blood sugar) can prevent diabetes caused by steroid treatments. It is for people who have prediabetes or mild diabetes and are about to receive a short course of steroids.
LondonAges 18 years+ - NCT07092618RecruitingPhase 2/Phase 3
Trial for keeping weight off after stopping GLP-1 meds
This study tests if other medicines (naltrexone, metformin, or rapamycin) can help people keep off weight they lost while taking GLP-1 drugs like Wegovy or Ozempic, after they stop taking them. It is for AgelessRx patients aged 40 to 85 who have lost at least 15 pounds on GLP-1s.
Chicago, IllinoisAges 40–85 - NCT06044025RecruitingPhase 1
Maintenance therapy for prostate cancer with rising PSA
This trial tests two medications (metformin and a turmeric compound) as a maintenance therapy for men with prostate cancer whose PSA is rising slowly after prior treatment. The goal is to see if these drugs can keep the cancer from growing while you take a break from standard hormone therapy.
Little Rock, ArkansasAges 18–100 - NCT07293325Recruiting
Semaglutide and Tirzepatide for slowing aging in adults with obesity
This trial tests if two newer weight-loss medications, semaglutide and tirzepatide, can help slow the aging process in adults with obesity. It compares the drugs to each other and to a placebo to see which might offer anti-aging benefits beyond weight loss.
HangzhouAges 18–75 - NCT07244575Recruiting
Metformin and nausea after general anesthesia study
This study looks at whether the diabetes medicine metformin, taken before surgery, affects the risk of nausea and vomiting after general anesthesia. If you take metformin and are having planned surgery, this trial may help understand its effects.
Guangzhou, GuangdongAges 18 years+ - NCT03925714RecruitingPhase 3
Testing a gene-related approach in people with prediabetes
This trial studies how changes involving p53 and SIRT1 may affect health in people with prediabetes. It may help researchers find better ways to stop or slow progression to type 2 diabetes.
CairoAges 18 years+ - NCT07074379Recruiting
Treatments for painless chronic pancreatitis
This study tests whether a procedure using a scope (endotherapy) or shock waves to break up stones can help people with painless chronic pancreatitis who have not had these treatments before.
Shanghai, Shanghai MunicipalityAges 18–85 - NCT03925701RecruitingPhase 3
Vildagliptin, with or without metformin, for fatty liver and diabetes
This trial studies how vildagliptin compares to vildagliptin plus metformin in people who have fatty liver disease along with type 2 diabetes. It may help find the safest and most effective way to improve liver health and diabetes control.
TantaAges 18 years+ - NCT07724132RecruitingPhase 3
Treatments for sustained response in Alzheimer's disease
This study tests whether a treatment (atomoxetine or metformin) can help people with Alzheimer's disease maintain an improved state for at least 18 months. It may help you or a loved one stabilize symptoms and slow disease progression.
CambridgeAges 55 years+ - NCT07339722RecruitingPhase 1
Study of LY4515100 in healthy volunteers
This trial tests a new oral medication in healthy volunteers to see how it moves through the body and how safe it is. Taking part helps researchers understand how the drug works before it's studied in people with a certain condition.
Dallas, TexasAges 18–65
Common questions
- Are there clinical trials studying Metformin?
- Yes. Clin2 currently lists 152 recruiting studies that include Metformin, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Metformin trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Metformin an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Metformin or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.