Treatment
Opioid clinical trials
We’re tracking 443 recruiting studies that include Opioid, each written for real people, not researchers, below.
Recruiting studies
- NCT05790252RecruitingPhase 3
Buprenorphine patch for starting opioid treatment during pregnancy
This Phase 3 study tests whether a skin patch can help pregnant people start buprenorphine treatment for opioid use disorder safely and effectively. It may help with easier “induction” (starting the medication) while you’re pregnant.
St Louis, MissouriAges 18–110 - NCT05804591RecruitingPhase 4
Pregabalin during weight-loss surgery to reduce pain
This trial tests whether pregabalin can help with pain control for people having laparoscopic sleeve gastrectomy (a weight-loss surgery). It may help reduce the discomfort around surgery and improve the overall recovery experience.
Warsaw, WarsawAges 18 years+ - NCT05817825Recruiting
Remote program to support recovery after opioid use
This study tests a new intensive outpatient program delivered by video or phone to help people with opioid use disorder (and other substance use disorders) stay on track after leaving the hospital. It may help by offering structured support while you are at home.
Boston, MassachusettsAges 18 years+ - NCT05877118Recruiting
Helping people get naloxone education at ED discharge
This trial tests ways to improve how people receive naloxone (an emergency overdose-reversal medicine) education when they leave the emergency department with a prescription kit. It may help patients and caregivers feel more confident using naloxone during an overdose emergency.
Hartford, ConnecticutAges 21–65 - NCT05888038Recruiting
Virtual reality to reduce pain after scoliosis surgery
This trial looks at whether virtual reality can lower pain for children and teens after scoliosis repair surgery, which may also reduce how much opioid pain medicine they need. If you join, you would use a virtual reality experience during the post-operative period.
Staten Island, New YorkAges 7–21 - NCT05940324RecruitingPhase 2
Ketamine study for OCD after prior treatment failed
This Phase 2 study tests how ketamine may work quickly in people with obsessive-compulsive disorder (OCD), especially after at least one standard treatment didn’t help. If you join, you’ll need to follow study procedures like fasting before the experimental visit and not enrolling in other medication trials during the study.
Stanford, CaliforniaAges 18–65 - NCT05957159RecruitingEarly Phase 1
Testing an alcohol brain imaging study based on opioid receptor balance
This early-phase study looks at how the brain’s opioid receptor balance may be different in people with alcohol use disorder (AUD), using brain scans and blood testing. It may help researchers understand why some people respond differently to alcohol and related treatments.
New Haven, ConnecticutAges 21–70 - NCT05973838Recruiting
Telemedicine support plus recovery coaching for multiple drug use
This study tests whether adding peer recovery support to a phone/video treatment program helps people stay in treatment longer and reduce polysubstance use. It focuses on adults in opioid use disorder care who have used other non-prescribed substances in the last three months.
Washington D.C., District of ColumbiaAges 18 years+ - NCT05981105Recruiting
Recovery and Chronic Pain After Knee Replacement
This study tests a special recovery program after knee replacement surgery to see if it helps reduce long-term pain. You may be eligible if you are having a first-time knee replacement for osteoarthritis, are between 18 and 65, and live near the hospital.
New York, New YorkAges 18–75 - NCT05985629RecruitingPhase 4
Numbing shot behind the knee for ACL surgery pain
This study tests whether an extra numbing shot (called IPACK) behind the knee helps reduce pain and the need for strong pain medicine after ACL reconstruction surgery. It's for patients who are having their first ACL surgery and are not using a donor graft.
Maywood, IllinoisAges 16 years+ - NCT05985811Recruiting
Ketamine for chronic pain and mood in adults
This trial tests if ketamine injections can improve both pain and mood in adults with chronic pain who also have a mood disorder and trouble sleeping. It may help if you already get regular ketamine treatments.
Surrey, British ColumbiaAges 20–99 - NCT05988710RecruitingPhase 4
Low-dose buprenorphine for pain in opioid-naive adults
This study tests a low-dose form of buprenorphine (a medicine for pain) placed inside the cheek. It is designed for people who have never taken opioids before, to see how well it works for pain and how likely it is to be misused.
Nashville, TennesseeAges 18–65 - NCT06032559RecruitingPhase 3
Mindfulness and methadone for chronic pain
This study tests if adding a mindfulness program (MORE) to regular methadone treatment helps people with long-term pain. It may improve pain and support recovery.
New Brunswick, New JerseyAges 18 years+ - NCT06051890RecruitingPhase 4
Assessing switching to long-acting buprenorphine injection in jail
This study tests whether switching from daily buprenorphine/naloxone (Suboxone) to a long-acting injectable buprenorphine (XRB) is safe and effective for men who are unsentenced and in jail for at least 4 days. It aims to see if the injection can help continue treatment without needing daily medication.
Boston, MassachusettsAges Any age - NCT06100172Recruiting
Ear Stimulation After Back Surgery
This study tests whether a gentle electrical stimulation placed on the ear (tAuricular Neurostimulation) can help reduce pain and improve recovery after lumbar spine surgery. It is for people who are already scheduled for a lumbar fusion or laminectomy and want to see if this non-invasive approach can ease their post-surgery discomfort.
Dallas, TexasAges 18–85 - NCT06103370Recruiting
HIV prevention via telemedicine and peer networks
This study tests how well a program combining telemedicine (virtual doctor visits) and peer support can help prevent HIV among people who inject drugs. You'd get trained, attend weekly group sessions, and invite a friend or partner to also take part.
Baltimore, MarylandAges 18 years+ - NCT06113211RecruitingPhase 4
Non-opioid pain control after fracture surgery
This trial tests a combination of non-opioid medications to manage pain after surgery for a broken bone, aiming to reduce or avoid the use of opioids. It may help you control pain without the risks of strong painkillers.
Detroit, MichiganAges 18–80 - NCT06136247Recruiting
Brain & thinking tests in opioid use disorder
This study tests whether brain scans and thinking tests can help understand opioid use disorder. It is for people on stable buprenorphine or methadone treatment.
Philadelphia, PennsylvaniaAges 18–60 - NCT06157840Recruiting
Sleep program for people on buprenorphine treatment
This trial tests a mobile health sleep program for people who are on buprenorphine for opioid use disorder and have trouble sleeping. It aims to help improve sleep and support your recovery journey.
Charleston, South CarolinaAges 18 years+ - NCT06206252Recruiting
Can Medical Cannabis Help Reduce Opioid Use?
This study tests whether medical cannabis can help people who take opioids for long-term pain reduce their opioid use. Participants will either use medical cannabis or continue without it for 3 months.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06223503Recruiting
Pain support service study for veterans after surgery
This study tests a telehealth pain support program for veterans having orthopedic surgery. It aims to help manage pain after surgery and reduce the need for long-term opioid use.
Salt Lake City, UtahAges 18 years+ - NCT06234631RecruitingPhase 2
CBD to reduce opioids after knee replacement
This study tests if a daily CBD capsule can help reduce the need for opioid pain pills after a first-time total knee replacement. It is for people with osteoarthritis who are having surgery and are willing to avoid cannabis for a short time before and after.
Ann Arbor, MichiganAges 18–80 - NCT06270147RecruitingPhase 2
Timing of nerve blocks for weight loss surgery pain
This trial tests whether giving a nerve block before or after bariatric surgery works better for pain control. It could help you have less pain and use fewer painkillers after your procedure.
Hamilton, OntarioAges 18 years+ - NCT06288711Recruiting
Video therapy for PTSD in people taking opioid medication
This trial tests a therapy called prolonged exposure (a type of talk therapy) delivered via video calls to help people with both opioid use disorder and PTSD. It aims to see if this approach can reduce PTSD symptoms.
Burlington, VermontAges 18 years+
Common questions
- Are there clinical trials studying Opioid?
- Yes. Clin2 currently lists 443 recruiting studies that include Opioid, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Opioid trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Opioid an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Opioid or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.