Treatment
Opioid clinical trials
We’re tracking 443 recruiting studies that include Opioid, each written for real people, not researchers, below.
Recruiting studies
- NCT07294118RecruitingPhase 2
Lidocaine and steroids for pain after brain bleed
This trial tests whether giving a numbing medicine (lidocaine) and steroids into the artery that covers the brain can help reduce pain after a brain bleed. It may be an option for people with a specific type of bleeding who have not had certain brain surgeries or procedures.
Galveston, TexasAges 18–100 - NCT07325279RecruitingPhase 1
Nalmefene Implant Safety Study in Healthy Adults
This trial tests a new implant form of the medicine nalmefene to see if it is safe and well-tolerated in healthy adults. It is an early-phase study that helps researchers understand how the body reacts to the implant before testing it in people with opioid use problems.
Morrisville, North CarolinaAges 18 years+ - NCT07334288Recruiting
Numbing injection for pain relief after lower back surgery
This study tests a numbing injection near the spine (retrolaminar block) to reduce pain after lower back surgery with hardware. It could help you use less pain medicine and recover more comfortably.
Santiago, Santiago MetropolitanAges 18–80 - NCT07337629Recruiting
Painkiller Before Nose Surgery: Paracetamol vs. Ibuprofen
This study tests whether giving a single dose of paracetamol or ibuprofen before nose surgery can reduce the need for stronger painkillers during and after the procedure. It may help you recover with less opioid pain medicine.
SamsunAges 18 years+ - NCT07179614Recruiting
Kentucky women's overdose recovery program
This trial tests a support program for women in Kentucky jails who have opioid or stimulant use disorder. It aims to reduce overdose risk after release by connecting them with community support.
Harlan, KentuckyAges 18 years+ - NCT07354919RecruitingPhase 2
Testing axelopran for advanced cancer patients on opioids
This trial tests if axelopran can help people with advanced prostate, breast, pancreatic, or lung cancer who are taking opioid pain medicines. It aims to see if the drug is safe and helps with bowel function.
Saint Louis Park, MinnesotaAges 18 years+ - NCT07365293Recruiting
Support for Families Affected by Opioid or Meth Use
This study tests a program that helps parents who are using opioids or methamphetamines get support for themselves and their families. It may be a good fit if you have Medicaid, live in certain counties, and are open to working with a coach.
Eugene, OregonAges Any age - NCT07375121Recruiting
Comparing two pain pump settings for mixed surgeries
This study compares two ways of delivering pain medicine through an IV pump (called PCA) after surgery. One method gives a steady dose, and the other slowly reduces the dose. The goal is to see which works better and has fewer side effects.
BeijingAges 18–65 - NCT01730781Recruiting
PET scan study to image cannabinoid receptors in the brain
This study uses a special brain scan (PET) to measure cannabinoid receptors—areas in the brain that interact with cannabis-like chemicals. It may help researchers better understand how these receptors relate to conditions such as schizophrenia, PTSD, opioid use disorder, or early psychosis risk.
New Haven, ConnecticutAges 18–55 - NCT07402577Recruiting
Pain and opioid use in young sarcoma survivors
This study looks at pain and opioid use in adolescents and young adults who have had sarcoma. It uses a smartphone app to track symptoms over 3 months to better understand cancer-related pain.
Buffalo, New YorkAges 12–70 - NCT07423650RecruitingPhase 4
Continuous Nefopam infusion after pancreas surgery
This trial tests if giving a steady dose of a painkiller called nefopam through an IV can help manage pain after a Whipple procedure (pancreatoduodenectomy). It aims to see if this approach reduces the need for other pain medications and improves recovery.
Cluj-Napoca, ClujAges 18–80 - NCT07439549RecruitingPhase 4
Quick-start buprenorphine with naloxone for opioid use disorder
This study tests a faster way to start buprenorphine (a medication for opioid use disorder) by using naloxone to briefly trigger mild withdrawal. This could help people get started on treatment more comfortably and quickly.
Vancouver, British ColumbiaAges 19 years+ - NCT07447856RecruitingPhase 1
Herbal plasters for pain relief while using opioids
This trial tests a topical herbal plaster to see if it can help reduce pain in people with cancer who are already taking opioids. The plaster is placed on the most painful area and may allow you to use less opioid medication.
Basking Ridge, New JerseyAges 18 years+ - NCT07630428Enrolling by invitation
Support programs after sexual assault medical exam
This study tests two support programs—STAR and TextSTAR—designed to help people after a sexual assault medical exam. The goal is to see which approach better supports your recovery and connects you with resources.
Louisville, KentuckyAges 18 years+ - NCT07539623RecruitingPhase 3
Pain relief with suzetrigine after heart or weight-loss surgery
This study tests whether suzetrigine, a new pain medication, can reduce the need for opioids (strong painkillers) after cardiac or bariatric surgery. The goal is to help patients manage pain with fewer opioid-related side effects.
New York, New YorkAges 18–85 - NCT07541417Recruiting
Peer Support for Starting Medication Treatment for Opioid Use
This study tests whether peer coaches—people with lived experience of opioid addiction—can help newly enrolled patients stay engaged with medication-based treatment through a mobile app. The goal is to improve treatment success by combining peer support with digital health tools.
Greenville, South CarolinaAges 18 years+ - NCT07561411Recruiting
Nerve blocks to reduce pain after breast removal surgery
This trial tests two types of nerve-blocking injections given during breast removal surgery to see which one better prevents long-term pain afterward. Both are given alongside general anesthesia and may help you recover with less chronic pain.
BeirutAges 18–80 - NCT07578545Recruiting
Pain management after minimally invasive chest surgery
This study tests whether combining a specific type of chest surgery (using small cameras) with numbing injections around nerves reduces pain and the need for strong pain medications after surgery. Researchers want to see if this approach helps patients recover better with less opioid use.
Antalya, MuratpaşaAges 18–75 - NCT07590752RecruitingPhase 2/Phase 3
Pain Relief Comparison for Abdominal Surgery
This trial compares two medications added to a numbing injection around your abdominal muscles during belly surgery to help manage pain after surgery. The study aims to find which combination works better and lasts longer.
Sahiwal, Punjab ProvinceAges 25–65 - NCT07616648Recruiting
How Opioid Pain Drugs Affect Sleep and Mood in Cancer Patients
This study examines how opioid medications (strong pain relievers) impact sleep quality and emotional well-being in cancer patients with moderate to severe pain. Researchers will track your sleep patterns and mood to better understand these side effects.
HangzhouAges 18–75 - NCT07630337Recruiting
Cryotherapy to reduce pain medication after knee replacement
This study tests whether applying cold therapy (cryotherapy) after knee replacement surgery helps patients need fewer opioid pain medications than standard care alone. If cryotherapy works, it could help you manage pain more safely after surgery.
Buenos Aires, Buenos AiresAges 18 years+ - NCT07633444Recruiting
Ear Stimulation to Reduce Pain After Abdominal Surgery
This study tests whether mild electrical stimulation applied to your ear can reduce pain and the need for pain medication after abdominal or urologic surgery. Researchers will try different stimulation frequencies to find what works best.
Salvador, Estado de BahiaAges 18–59 - NCT07606638Enrolling by invitation
Pain Relief Options for Oral Cancer Patients
This study compares two different pain management approaches for people with oral cancer: opioid medication versus a combination of pregabalin (a nerve pain reliever) and naproxen sodium (an anti-inflammatory painkiller). The goal is to see which approach works better and is safer for controlling cancer-related pain.
Lahore, Punjab ProvinceAges 18 years+ - NCT07217197Enrolling by invitation
A monitor to detect breathing problems after surgery
This trial tests a new respiratory monitoring system to see if it can detect and predict opioid-induced respiratory depression (OIRD) — when pain medicines slow your breathing too much — in patients recovering from surgery. The monitor uses a face mask, nasal cannula, and small sensors to track breathing continuously, so that doctors can step in early if there is a problem.
Philadelphia, PennsylvaniaAges 18 years+
Common questions
- Are there clinical trials studying Opioid?
- Yes. Clin2 currently lists 443 recruiting studies that include Opioid, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Opioid trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Opioid an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Opioid or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.