Treatment
Opioid clinical trials
We’re tracking 442 recruiting studies that include Opioid, each written for real people, not researchers, below.
Recruiting studies
- NCT06507345Recruiting
Non-opioid pain relief after breast surgery
This trial tests whether non-opioid pain medicines can effectively control pain after mastectomy or lumpectomy, allowing you to go home the same day without needing strong opioids.
Montreal, QuebecAges 18 years+ - NCT06651333Recruiting
Brain scans during opioid addiction treatment
This study uses brain scans to understand how methadone or buprenorphine treatment affects the brain, with the goal of helping people stay in treatment and avoid relapse. You would need to be recently started on one of these medications and be able to undergo MRI scans.
Hartford, ConnecticutAges 18–50 - NCT07750639Enrolling by invitationPhase 4
Reducing painkiller use after hand surgery
This study tests a new approach to prescribing fewer opioid pain pills after hand, wrist, or elbow surgery. It aims to help reduce the risk of opioid misuse while still controlling pain after surgery.
Orlando, FloridaAges 18 years+ - NCT05854303Recruiting
Stopping opioids’ effects on swallowing in esophagus problems
This study looks at how stopping opioid pain medicines affects esophagus function (the tube that carries food to the stomach), including in people with or without symptoms. It may help researchers understand what changes to expect after opioid cessation in a pain rehabilitation program.
Rochester, MinnesotaAges 18 years+ - NCT07405398Recruiting
Smartwatch study to detect opioid use and withdrawal
This study uses a smartwatch to track wrist data and help detect when someone is using opioids or experiencing withdrawal. It's designed for people with opioid use disorder who are starting or already on treatment with methadone or buprenorphine.
Wilmington, North CarolinaAges 22 years+ - NCT04811014RecruitingPhase 4
Helping young adults stop opioids after an emergency visit
This study offers an engagement program for young people who tested positive for opioids and meet criteria for opioid dependence. The goal is to help participants stop opioid use safely and learn whether this approach works well in the real-world emergency setting.
Houston, TexasAges 13–17 - NCT07221786Recruiting
Opioid reduction before spine surgery
This trial tests whether slowly reducing opioid pain medications before spine surgery can lead to a better recovery afterward. It is for adults already taking daily opioids who have major spine surgery planned at least a month away.
Philadephia, PennsylvaniaAges 18 years+ - NCT07427043RecruitingPhase 3
Opioid-free pain plan for robotic prostate surgery
This trial tests a pain management strategy that avoids opioids during and after robotic prostate surgery. It aims to reduce opioid use and side effects while keeping you comfortable.
Boston, MassachusettsAges 45 years+ - NCT05511909RecruitingPhase 2
Buspirone study for opioid withdrawal symptoms
This Phase 2 study tests whether buspirone can help reduce symptoms during opioid detox (withdrawal). You may be able to take part if you have opioid withdrawal and are planning medically supervised detox.
Baltimore, MarylandAges 18–75 - NCT07780097Recruiting
Starting opioid addiction medication after a hospital stay
This study helps people who are in the hospital for opioid use disorder start a medication like methadone or buprenorphine after they leave the hospital. It aims to make starting treatment easier and improve recovery.
Cincinnati, OhioAges 18 years+ - NCT06651177RecruitingPhase 2
Tirzepatide with buprenorphine for opioid use disorder
This study tests whether adding tirzepatide, a medication used for weight and blood sugar, to buprenorphine treatment helps people with opioid use disorder. It aims to see if the combination improves outcomes compared to buprenorphine alone.
Jacksonville, FloridaAges 18 years+ - NCT06731348Enrolling by invitationPhase 4
Pain pill options after pelvic surgery
This trial compares two different amounts of opioid pain pills after surgery for women with pelvic floor problems. The goal is to see if a lower dose still provides good pain relief and keeps patients satisfied.
Bethesda, MarylandAges 18 years+ - NCT06823453Recruiting
Training friends and family to support people who use opioids
This study trains friends and family members of people who use opioids, so they can provide better support and reduce stigma. It also includes people who use opioids to see if this training improves their relationship and well-being.
Chicago, IllinoisAges 18 years+ - NCT06548490RecruitingPhase 2
Semaglutide for Opioid Use Disorder
This study tests whether a once-weekly injection of semaglutide (a GLP-1 receptor agonist) can reduce opioid use in people who are already on buprenorphine or methadone but still using opioids. It lasts about 19 weeks.
Baltimore, MarylandAges 18–75 - NCT07693270Recruiting
Study looking for markers of pain and opioid response after injury or surgery
This study is looking for biological markers (like blood tests) that can predict how people will respond to pain and opioids after a traumatic injury or surgery. The goal is to help doctors tailor pain treatment to each person.
La Jolla, CaliforniaAges 18 years+ - NCT04894864RecruitingPhase 4
Opioid-free anesthesia for elective abdominal aortic aneurysm surgery
This trial studies an “opioid-free” anesthesia and pain plan during planned open surgery for an abdominal aortic aneurysm. The goal is to see whether this approach reduces surgical stress and pain compared with usual care.
Heraklion, CreteAges 40–85 - NCT05027919RecruitingPhase 2
Testing ways to predict opioid withdrawal during a taper
This Phase 2 study looks at what opioid withdrawal looks like in the body and whether they can measure it in a meaningful way. You may join if you have an opioid use disorder, can show physical dependence, and are interested in tapering (gradually reducing) opioids under study care.
Baltimore, MarylandAges 18–65 - NCT05172739RecruitingPhase 4
Opioid-free anesthesia during lung surgery for early lung cancer
This study tests whether an opioid-free pain/anesthesia plan during elective lung surgery can reduce surgical “stress” on the body and affect the immune system. You may be eligible if you have early-stage non-small cell lung cancer and are scheduled for a specific type of surgery (VATS lobectomy).
Heraklion, CreteAges 18–80 - NCT06358040Recruiting
Opioid dispenser after back surgery trial
This trial tests a special device that gives you pain medication (opioids) after back surgery, instead of a prescription. It may help you use just the right amount of pain medicine, and you'll use your smartphone for follow-up visits.
New York, New YorkAges 18 years+ - NCT06487533Recruiting
Sensing opioid withdrawal and cravings with wearable sensors
This study uses wearable sensors to track physical signs of opioid withdrawal and cravings over 14 days. It aims to better understand these symptoms in people currently taking or planning to start medication for opioid use disorder.
Center City, MinnesotaAges 18–50 - NCT06806163Recruiting
Preventing Opioid Overdoses with Smart Reminders
This study tests whether a computer program can help doctors and patients have a conversation about safe opioid use. It uses information from your medical records to send reminders to your doctor, aiming to prevent overdoses.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06872190Recruiting
CDS tool for opioid use disorder in the ED
This trial tests a clinical decision support tool for emergency department providers at UCSF. It helps doctors give better care that considers social needs alongside opioid use treatment. The study will ask providers and patients about how well this tool works.
San Francisco, CaliforniaAges 18 years+ - NCT06915558Recruiting
Reducing inflammation in weight loss surgery
This trial tests a method to control inflammation during bariatric surgery. It may help patients recover better and have fewer complications.
Barcelona, BarcelonaAges 18–65 - NCT06949826RecruitingPhase 4
Buprenorphine for pain after ankle fracture surgery
This trial tests if buprenorphine, a non-opioid pain medicine, works well for people who have not used opioids before. After ankle fracture surgery, you would get buprenorphine instead of stronger opioids to see if it controls pain just as well with fewer side effects.
St Louis, MissouriAges 18 years+
What Opioid is being studied for
Conditions with recruiting Opioid studies.
Common questions
- Are there clinical trials studying Opioid?
- Yes. Clin2 currently lists 442 recruiting studies that include Opioid, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Opioid trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Opioid an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Opioid or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.