Treatment
Treatment as Usual clinical trials
We’re tracking 315 recruiting studies that include Treatment as Usual, each written for real people, not researchers, below.
Recruiting studies
- NCT06288711Recruiting
Video therapy for PTSD in people taking opioid medication
This trial tests a therapy called prolonged exposure (a type of talk therapy) delivered via video calls to help people with both opioid use disorder and PTSD. It aims to see if this approach can reduce PTSD symptoms.
Burlington, VermontAges 18 years+ - NCT06281184Enrolling by invitation
Long-term follow-up of methotrexate for hand osteoarthritis
This study follows up on people who took part in the MERINO trial to see if methotrexate has lasting benefits for hand osteoarthritis. It aims to understand how the drug affects pain and joint health over 30 months.
OsloAges 18 years+ - NCT06278922Recruiting
A therapy toolkit for Deaf people with alcohol and trauma issues
This study tests a therapy toolkit designed for Deaf or hard-of-hearing people who struggle with alcohol use and have experienced trauma. The therapy is provided in ASL via video sessions, and the goal is to see if it helps reduce drinking and PTSD symptoms.
Worcester, MassachusettsAges 18 years+ - NCT06236347Enrolling by invitation
Rural COPD study using e-visits for smokers
This study tests whether online e-visits can help rural smokers without COPD quit smoking. It uses smartphone tools and mailed devices to track progress remotely.
Charleston, South CarolinaAges 40 years+ - NCT06239285Recruiting
Virtual reality to prevent gun violence after injury
This trial tests whether a virtual reality program can help people who have been violently injured avoid future violence, especially gun violence. It's designed for adults treated at VCU's trauma center.
Richmond, VirginiaAges 18 years+ - NCT06210711Recruiting
Prolonged exposure therapy for trauma injury patients
This study tests if prolonged exposure therapy can help people who were injured in a trauma and admitted to a Level I trauma center. It aims to reduce the psychological impact of the traumatic event, such as PTSD symptoms.
Dallas, TexasAges 18–75 - NCT06226155Recruiting
HIV prevention support for pregnant women in Zimbabwe
This study in Zimbabwe tests a program to help pregnant women start and stay on PrEP (medication that prevents HIV). It aims to make PrEP easier to use during pregnancy for women who are at risk of HIV.
HarareAges 15–55 - NCT06102902RecruitingPhase 1
New drug added to chemotherapy for BRAF-mutated colorectal cancer
This trial combines a new drug called ZEN003694 with two standard chemotherapy drugs (cetuximab and encorafenib) to see if it can help people with a specific type of colorectal cancer that has the BRAF V600E mutation. This mutation makes the cancer grow, and the new drug targets it, potentially making the treatment more effective.
Costa Mesa, CaliforniaAges 18 years+ - NCT06097221Recruiting
Advancing sleep timing to improve depression
This trial tests whether advancing your sleep timing (going to bed and waking up earlier) can improve depression symptoms. It is for people recently discharged from a psychiatric hospital who have a delayed sleep schedule.
Copenhagen, FrederiksbergAges 18 years+ - NCT06058377RecruitingPhase 3
Adding immunotherapy to chemo for stage II-III breast cancer
This trial tests whether adding the immunotherapy drug durvalumab to standard chemotherapy works better than chemo alone for people with hormone receptor positive, HER2 negative breast cancer that is stage II or III and has a high-risk genetic score (MammaPrint High Risk 2).
Birmingham, AlabamaAges 18 years+ - NCT05078970Recruiting
Teen suicide intervention study for high-risk times
This study tests a suicide intervention approach for teens who are having suicidal thoughts or behaviors and are currently in an emergency or hospital setting. It may help you and your care team better support teens during the most risky period.
Columbus, OhioAges 11–17 - NCT05287711Recruiting
Motivational alcohol support to help prevent partner violence
This study tests an extra (adjunct) counseling approach to reduce harmful alcohol use in Veterans enrolled in the Strength at Home program. The goal is to help prevent intimate partner violence (IPV), especially when alcohol is involved.
Boston, MassachusettsAges 18 years+ - NCT05962437Recruiting
Smartphone app for fibromyalgia pain management
This trial tests a smartphone app that teaches you skills to cope with fibromyalgia pain and improve your quality of life. It's based on a type of therapy called Acceptance and Commitment Therapy (ACT) that helps you accept pain and live a fuller life.
Barcelona, BarcelonaAges 18–70 - NCT05920252Recruiting
Phone-based suicide risk support for teens in DBT
This trial tests whether a smartphone tool can help reduce suicide risk for teens who are already in an intensive therapy program (DBT). It may help you or your family recognize risk earlier and use skills more consistently between sessions.
New York, New YorkAges 13–18 - NCT05884476Recruiting
Re-checking suicidal thoughts in Veterans during a study
This study looks at a way to re-evaluate and respond to suicidal thoughts in Veterans. It may help improve how support is offered when someone has had thoughts of suicide recently.
New Orleans, LouisianaAges 18 years+ - NCT05861752Recruiting
Study of sexual risk behaviors and mental health patterns
This case-control study looks at people with specific sexual behavior-related conditions (like certain paraphilias, compulsive sexual behavior, or sex during sleep) to understand factors linked with risk for sexual violence. The goal is to learn what patterns may be involved so better help and prevention strategies can be developed.
Stockholm, Stockholm CountyAges 18 years+ - NCT05859204Enrolling by invitation
Exercise groups to improve mental health in hospital
This study tests whether joining structured exercise groups while you’re an inpatient in a psychiatric unit can improve mood, mental wellbeing, and overall comfort. It’s designed to be adjustable for different mobility needs and to be safe for participating patients.
Baltimore, MarylandAges 18 years+ - NCT05823220Enrolling by invitation
Homelessness support added to hospital discharge planning
This trial tests whether adding homelessness “diversion” services to emergency department discharge plans can help people avoid becoming homeless. It may be helpful if you’ve just left the hospital and you’re at high risk of housing instability.
Houston, TexasAges 18 years+ - NCT05842161Recruiting
Smoking cessation program for people with HIV and TB in South Africa
This study is testing a program to help people who are living with HIV and TB to stop smoking. It aims to see if quitting smoking improves their engagement with HIV and TB care.
RondeboschAges 18 years+ - NCT05803382RecruitingPhase 1
Adding a new drug to capecitabine for metastatic colorectal cancer
This Phase 1 study tests a new anti-cancer drug (ZEN003694) added to the usual chemotherapy capecitabine. It is for adults with colorectal cancer (and possibly other cancers) that has spread or cannot be removed and has continued despite prior standard treatment.
Irvine, CaliforniaAges 18 years+ - NCT05796401RecruitingPhase 3
Personalized care program for early psychosis outcomes
This trial tests whether a personalized care plan improves day-to-day functioning for people in the early stages of psychosis. It aims to see if adding structured support after a recent diagnosis can help you function better.
BrestAges 15–30 - NCT05793151Recruiting
Guided care to start cancer treatment on time after surgery
This trial tests a navigation program (help from a care coordinator) versus usual care to help people start the recommended “next-step” treatments (like radiation, sometimes with chemo) on time after surgery. It’s for certain stages of squamous cell cancer in the head and neck area where late treatment could matter.
St Louis, MissouriAges 18 years+ - NCT05770479Enrolling by invitation
Testing long-lasting cognitive training for older veterans
This study looks at whether a cognitive training program you’ve already completed can keep helping over time, and whether it can be improved with “booster” sessions. It may help older veterans maintain thinking and daily functioning skills after earlier training.
San Diego, CaliforniaAges 55 years+ - NCT05764759Recruiting
Help with quitting smoking using phone and primary care support
This study tests a new way to help people quit smoking in rural primary care settings using regular phone check-ins and air/smoke measurements. If you’re trying to stop, it may offer structured support and monitoring to help you quit.
Charleston, South CarolinaAges 18 years+
Common questions
- Are there clinical trials studying Treatment as Usual?
- Yes. Clin2 currently lists 315 recruiting studies that include Treatment as Usual, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Treatment as Usual trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Treatment as Usual an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Treatment as Usual or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.