Methadone to improve recovery after planned heart surgery
Treatments studied
Part of Pain clinical trials.
This trial looks at whether giving methadone during planned heart surgery can improve how patients feel and recover afterward. It will mainly compare recovery quality using a patient questionnaire.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are scheduled for elective heart surgery using a heart-lung machine (CPB).
- Your kidneys are working well enough (not on dialysis, and creatinine is not very high).
- Your liver tests are not significantly elevated.
- You do not need oxygen at home due to lung disease.
- You are not dependent on strong heart-support medicines before surgery (inotropes) or an intraaortic balloon pump.
- You have no allergy to methadone or fentanyl, and you don’t currently need opioids for major pain or have recent opioid misuse.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether the pain medicines methadone and hydromorphone affect the heart’s electrical timing after general anesthesia and surgery. It may help doctors choose the safer option for patients who need strong pain control after an operation.
This trial tests whether a single dose of methadone given during heart surgery can improve pain control and recovery. It may be an option for people having planned (not emergency) heart surgery.
This trial tests if methadone given through a vein can control pain better after heart surgery done through a breastbone incision. It may be an option for adults having planned heart surgery who are expected to wake up and breathe on their own within 12 hours.
This trial tests whether methadone—a strong pain medication—helps manage pain better after intermediate-complexity surgery. If it works, it could reduce pain and the need for other opioids after your operation.
This Phase 3 trial tests whether giving methadone during hip or knee replacement surgery can reduce pain after surgery. It may help some people use less rescue pain medicine afterward, but it also has safety checks for kidney, liver, heart, and opioid-related risks.
This trial tests if giving a single dose of methadone right before and during spine surgery can help manage pain better. If it works, you might need fewer other pain medicines after surgery.
Hear when a new Quality of Recovery Scores trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.