Xenon to protect the brain after out-of-hospital cardiac arrest
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests whether xenon gas can help protect the brain in adults who are in a coma after an out-of-hospital heart arrest. It aims to improve recovery by reducing brain injury during the critical time right after resuscitation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 to 80 years old
- The cardiac arrest is believed to be from a heart-related cause, not an injury
- The person had a sustained return of circulation when arriving at the emergency department
- They are not responding to verbal commands (Glasgow Coma Scale score under 8)
- Doctors decide they are eligible for targeted temperature management (TTM)
- The trial treatment can start within 4 hours after arriving at the emergency department
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests a special way to cool the lungs quickly after a cardiac arrest, using a liquid ventilation method. The goal is to see if this can help protect the brain and other organs after the heart is restarted.
This study tests an inhaled gas called xenon to see if it can safely reduce brain inflammation. The study is for healthy volunteers aged 55-75 to check safety and early signs of benefit.
This study tests if giving magnesium soon after a cardiac arrest can protect the brain and improve recovery. It is for adults who have been brought back to life after a heart stoppage.
This Phase 2 study tests whether xenon gas can reduce brain injury after an aneurysmal subarachnoid hemorrhage (a bleeding caused by a brain aneurysm). It aims to help people who are very sick right after the bleeding by improving brain function outcomes.
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