Treatment
Xenon clinical trials
We’re tracking 33 recruiting studies that include Xenon, each written for real people, not researchers, below.
Recruiting studies
- NCT03331302RecruitingPhase 1/Phase 2
Tested lung imaging scans in stable COPD patients
This study compares two ways of seeing how well your lungs work: a special MRI scan and another scan that uses a different gas. It may help researchers find which imaging test best reflects lung function in people with COPD.
Charlottesville, VirginiaAges 18 years+ - NCT06080100RecruitingEarly Phase 1
Xenon sedation for stress relief before eye surgery
This study tests whether a calming gas called xenon can help reduce stress and anxiety before a specific type of laser eye surgery (SMILE). It may help people who feel very nervous or anxious before their procedure.
KrasnodarAges 18–45 - NCT03909477Recruiting
Study of MRI brain scans in cannabis smokers over time
This study follows people who currently or used to smoke cannabis to see how cannabis use may change certain MRI scan signals in the brain over time. You may help researchers understand the effects of cannabis smoking and how brain imaging changes can be measured safely.
London, OntarioAges 18–85 - NCT04662658RecruitingPhase 1/Phase 2
Testing a special MRI gas scan of healthy lungs
This study tests a special MRI scan that uses a “hyperpolarized” gas to look at how well the lungs are working. It’s likely looking for safe imaging results and clear lung measurements in people without lung disease.
Charlottesville, VirginiaAges 18 years+ - NCT04696523RecruitingPhase 2
Xenon gas for brain injury after a ruptured brain aneurysm
This Phase 2 study tests whether xenon gas can reduce brain injury after an aneurysmal subarachnoid hemorrhage (a bleeding caused by a brain aneurysm). It aims to help people who are very sick right after the bleeding by improving brain function outcomes.
Helsinki, HelsinkiAges 18 years+ - NCT06945614RecruitingPhase 1
Xenon gas for brain inflammation safety study
This study tests an inhaled gas called xenon to see if it can safely reduce brain inflammation. The study is for healthy volunteers aged 55-75 to check safety and early signs of benefit.
Boston, MassachusettsAges 55–75 - NCT02740868RecruitingPhase 2
Breathing MRI using xenon gas to study lungs
This trial uses a special breathing MRI (you breathe a gas mixture) to measure how well your lungs work. It studies healthy kids and people with lung conditions like cystic fibrosis or asthma, and it may help researchers better understand lung function and flare-ups.
Toronto, OntarioAges 8 years+ - NCT02272049RecruitingPhase 1/Phase 2
Hyperpolarized gas MRI scan for lung imaging in people 6+
This trial tests a special MRI scan that uses an inhaled, tracer gas to create clearer pictures of how your lungs work. It may help doctors see lung function more precisely in children and adults who can safely complete the scan.
Cincinnati, OhioAges 6 years+ - NCT02484885Recruiting
Breath-hold MRI study to test imaging reliability
This study uses a special MRI gas (xenon-129) and scanner software to check how reliably images can be repeated. You may be able to help researchers improve MRI technology, as long as you can safely do the breathing and MRI scanning steps.
London, OntarioAges 18–85 - NCT02723500Recruiting
Xenon MRI scan for people with chronic lung disease
This study tests whether a special MRI scan using xenon gas can be done safely and provide useful information in people with chronic lung conditions. You may be able to take part if your breathing tests and oxygen levels are adequate and you can complete the MRI safely.
London, OntarioAges 18–85 - NCT04991454RecruitingPhase 2
Xenon mri to image lung blood flow in pulmonary hypertension
This trial uses a special MRI scan with xenon gas to take detailed images of how blood moves through your lungs. It aims to see if this imaging can help doctors better understand and manage pulmonary hypertension, which is high blood pressure in the lungs.
Durham, North CarolinaAges 18–75 - NCT04761393Recruiting
Testing a lung protein in COPD sputum samples
This study looks at a lung protein called MMP12 in sputum (mucus) to better understand COPD. It may help researchers learn which COPD changes are linked to disease severity and lung damage.
Hamilton, OntarioAges 40–85 - NCT06856525RecruitingPhase 2/Phase 3
MRI scan to study lung health in e-cigarette users
This study tests a new type of MRI scan to see how e-cigarettes affect your lungs. It's for young adults who vape nicotine regularly. The results may help doctors understand vaping-related lung damage.
Durham, North CarolinaAges 18–35 - NCT04616313Recruiting
MRI and breathing tests in people who vape
This study uses a special lung scan (MRI) and breathing tests to understand how vaping affects lung structure and function. It may help researchers learn what early lung changes happen after starting vaping, even if you don’t feel sick.
London, OntarioAges 16 years+ - NCT06775379RecruitingPhase 3
Azetukalner vs. placebo for major depression
This trial tests an investigational medication called Azetukalner against a placebo to see if it helps reduce symptoms of major depressive disorder. You may qualify if you are currently in a depressive episode that started in adulthood and have not tried or failed only a few antidepressants.
Phoenix, ArizonaAges 18–74 - NCT07076407RecruitingPhase 3
Testing a new antidepressant pill for depression
This study tests an experimental oral pill called azetukalner against a placebo to see if it safely reduces symptoms of major depressive disorder. It is for adults who are currently in a depressive episode lasting 6 weeks to 2 years and have not already tried multiple antidepressants that failed.
Dothan, AlabamaAges 18–74 - NCT06922110Enrolling by invitationPhase 3
Long-term study of azetukalner for depression
This study is for people who already completed a previous trial of azetukalner for major depressive disorder. It tests the long-term safety and effects of continuing the medication.
Phoenix, ArizonaAges 18 years+ - NCT04793867Recruiting
MRI study of lung differences in cystic fibrosis and bronchiectasis
This study uses MRI scanning to better understand how the lungs differ in people with cystic fibrosis (CF) and in people with non-CF bronchiectasis. The results may help doctors understand disease changes over time and guide future care, especially for children and teens.
Cincinnati, OhioAges 5–100 - NCT05041140Recruiting
Xenon MRI test for lung problems after stem cell transplant
This study uses a special MRI test with xenon gas to look at lung function in adults who had a stem cell transplant and now have breathing-related complications. It may help doctors measure lung impairment more clearly and track changes over time.
Houston, TexasAges 18 years+ - NCT05667142RecruitingPhase 3
Testing an add-on drug for hard-to-control generalized convulsive seizures
This Phase 3 trial tests XEN1101 added to your current seizure medicines for people with primary generalized tonic-clonic seizures. It’s for seizures that have not fully stopped even after trying at least two appropriate medicines.
Mobile, AlabamaAges 12 years+ - NCT05716100RecruitingPhase 3
Study drug for focal epilepsy that isn’t controlled on current meds
This trial tests XEN1101 compared with a placebo (inactive pill) in people with focal-onset seizures that haven’t been fully controlled despite trying at least two anti-seizure medicines. If you qualify, you may help researchers see whether the study drug reduces seizure frequency and improves control.
Little Rock, ArkansasAges 18 years+ - NCT06104228RecruitingPhase 2
Xenon MRI to detect and track pulmonary hypertension
This trial uses a special MRI scan (using xenon gas) to see how well the lungs are working in people with pulmonary arterial hypertension (PAH). It aims to improve diagnosis and monitoring of PAH from connective tissue disease or unknown cause.
Durham, North CarolinaAges 18–75 - NCT06351345RecruitingPhase 2
Xenon imaging study for pulmonary hypertension patients on sotatercept
This trial uses a special imaging technique (xenon MRI) to see how well the lungs are functioning in people with pulmonary arterial hypertension (PAH) who are being treated with the drug sotatercept. It aims to understand if the drug improves lung function.
Durham, North CarolinaAges 18–75 - NCT05718817Enrolling by invitationPhase 3
Long-term study of XEN1101 for people with epilepsy
This study gives XEN1101 in an open-label way (everyone knows they’re getting the drug) to people who finished earlier epilepsy studies. It aims to see how the treatment continues to work and whether it’s safe over the long term.
Phoenix, ArizonaAges 12 years+
What Xenon is being studied for
Conditions with recruiting Xenon studies.
Common questions
- Are there clinical trials studying Xenon?
- Yes. Clin2 currently lists 33 recruiting studies that include Xenon, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Xenon trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Xenon an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Xenon or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.