VNS for long-term depression that hasn’t improved with treatment
Part of Mental health clinical trials.
This trial studies how well and how efficiently VNS therapy works for people with long-lasting or repeated major depression that hasn’t responded to enough antidepressant treatments. It may help patients who are already receiving depression treatment but are still struggling.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old
- You have major depression for over 2 years or you’ve had at least 2 past episodes
- Your depression has not improved enough after trying enough standard treatments (checked by your local doctor, and confirmed with an interview called MINI)
- You are currently on at least one depression treatment (medicine, maintenance ECT, or therapy) or a mood-stabilizing treatment if you have bipolar disorder
- You can come to clinic visits and complete study questionnaires/check-ins reliably
- You do not have severe substance/alcohol abuse or a current psychotic disorder (like schizophrenia or related disorders), and you don’t have severe personality disorder that would make study participation hard
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
This study looks at how vagus nerve stimulation (VNS) affects brain activity using EEG and MRI, in people already in the REVEAL study with a VNS device for depression. It aims to better understand how VNS helps treat depression.
This trial tests if deep brain stimulation (a device that sends tiny electrical pulses to mood-related brain areas) can help people with tough-to-treat depression. It uses brain-signal monitoring to see which patterns predict improvement.
This study looks at an EEG brain test (with light flashing and breathing tasks) to predict whether vagus nerve stimulation (VNS) will help control seizures in adults with drug-resistant epilepsy. It may help doctors choose the best people for VNS and better plan treatment.
This trial studies whether a device that stimulates the vagus nerve (VNS) can help people with treatment-resistant depression or related mood disorders that have not improved despite multiple therapies. It may help by targeting mood symptoms when other treatments haven’t worked well.
This study tests whether taVNS, TMS, or both can improve depression symptoms. It may help people whose depression has not improved enough with usual treatments like antidepressant pills or talking therapy.
Hear when a new Treatment Resistant Depression trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.