Brain stimulation for severe depression that hasn't improved with other treatments
Part of Mental health clinical trials.
This trial tests if deep brain stimulation (a device that sends tiny electrical pulses to mood-related brain areas) can help people with tough-to-treat depression. It uses brain-signal monitoring to see which patterns predict improvement.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 16 to 30 years old.
- Diagnosed with major depression that has lasted at least 2 years, or you've had 4 or more separate episodes (the current episode lasting at least 1 year).
- You've tried at least 3 different depression medications from at least 2 different drug types, and they didn't work well enough.
- You've either refused, couldn't tolerate, or didn't benefit from electroconvulsive therapy (ECT).
- Your current depression symptoms are moderate to severe (score of 20 or higher on a standard rating scale).
- No other major mental health conditions like bipolar disorder, schizophrenia, or severe personality disorders.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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