De-escalating radiation after HPV head and neck cancer surgery
Part of Cancer, Ear, nose & throat, Mouth & dental clinical trials.
This study looks at whether some people with HPV-positive throat/oropharynx cancer can safely receive a less intense form of radiation (and sometimes chemo) after surgery. It aims to reduce treatment burden while keeping the cancer under control, based on how high-risk the pathology looks.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had surgery to remove an oropharynx squamous cell cancer, and the lymph nodes in the neck were surgically removed (neck dissection) on the tumor side.
- Your pathology and doctor’s tumor-board decision require extra treatment after surgery with radiation or radiation plus chemo (adjuvant therapy).
- Your overall health is good enough for study participation (ECOG 0–1).
- Your surgical/biopsy details must place you in the study’s intermediate- or high-risk group.
- You can start the planned radiation within 7 weeks after your last operation, and there is no distant spread (no metastasis).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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