Maintenance therapy after stem cell transplant for B-ALL
Part of Blood & lymphatic, Cancer, Immune system & allergy, Infections clinical trials.
This trial tests whether three targeted medicines (decitabine, venetoclax, and blinatumomab) can help prevent leukemia from coming back after a stem cell transplant. It is for people with B-cell ALL who have no detectable remaining leukemia cells and are at least 3 months past transplant.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia and have had a donor stem cell transplant.
- No leftover leukemia cells (MRD) can be found in your blood or bone marrow before joining.
- It must be at least 3 months since your transplant, and your blood counts should be recovering (white cells above 500, platelets above 20).
- Your liver and kidney function need to be reasonably good.
- You should not have active GVHD that requires steroids, uncontrolled infections, or serious heart problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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