Reduce recurrent stroke with a PFO closure device and antiplatelet pills
Part of Brain & nervous system, Genetic & congenital, Heart & circulation clinical trials.
This study looks at whether closing a heart opening called a patent foramen ovale (PFO) with a special septal occluder, along with antiplatelet medications, can lower the risk of another stroke. It is for people who recently had a stroke thought to be caused by a clot that traveled from the heart but without another clear source.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had an ischemic stroke (from a blocked blood vessel) within the past 12 months, and your neurologist believes it was an “unexplained embolic” type.
- Tests show you have a PFO, seen on a bubble test of the heart (through the esophagus or a brain blood-flow test).
- You can safely take antiplatelet medicine (blood-thinning to prevent clots) as directed.
- You do not have atrial fibrillation or atrial flutter (an irregular heart rhythm).
- You do not have certain heart or stroke-related problems that raise risk or could interfere with accurate results (for example prior brain bleeding, significant valve or vessel disease, or other types of heart holes).
- You are not pregnant or planning pregnancy for about 2 years after enrollment, and you are not dealing with an untreated serious infection.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a new device to close a PFO (a small hole between the upper chambers of the heart) in people who have had a stroke caused by a blood clot. The goal is to prevent future strokes by blocking the hole.
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This trial compares two devices used to close a hole in the heart (called a PFO) in adults who have had a stroke or mini-stroke (TIA) within the last year. The goal is to see which device works better to prevent future strokes.
This trial studies ways to close a patent foramen ovale (PFO) to help prevent another stroke in people whose prior stroke had an unknown cause. If you qualify, you may receive one of the PFO closure approaches the study is comparing.
This trial looks at the safety and results of closing a PFO (a small hole in the heart) in people who have had a stroke or embolism with no other clear cause. If you qualify, doctors will close your PFO using a small tube inserted through a blood vessel and then follow your health over time.
This trial tests whether closing a hole in the heart (a PFO) with a special device can help prevent another stroke after an unexplained stroke. You may be a candidate if your stroke likely happened because blood can pass through this PFO.
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