Brain stimulation surgery for treatment-resistant depression
Part of Mental health clinical trials.
This trial studies whether deep brain stimulation (DBS)—a surgically placed brain device—can reduce severe, long-lasting depression that hasn’t responded to many treatments. It may help people whose depression has persisted despite trying multiple antidepressant and other evidence-based therapies.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 25 to 70, and you can sign consent papers
- Your main diagnosis is major depressive disorder without psychosis, and you are in a current depressive episode
- Your depression symptoms have lasted at least 2 years, or you’ve had more than 3 lifetime episodes
- Your depression severity scores must be high enough (Hamilton Depression Rating Scale), and daily functioning must be limited (score 50 or less)
- Your depression must be “treatment-resistant,” meaning you failed at least 4 adequate antidepressant or approved treatment trials during this episode
- You must be able to follow study and device care instructions
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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