Testing breathing support needs in COPD with high CO2
Part of Lungs & breathing clinical trials.
This trial studies how different breathing support strategies affect people with COPD who have high carbon dioxide (CO2) in their blood. It may help care teams choose safer respiratory support after a breathing machine is stopped.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have COPD that has been graded as GOLD C or D
- Your lung test shows poor airflow (FEV1 under 65%)
- Your blood gases show high CO2: pH is low (below 7.35) and CO2 is high (PaCO2 at least 45 mmHg), and you were on a breathing ventilator for over 24 hours
- After stopping the breathing machine, your blood gases stay with pH above 7.35 and CO2 above 45 mmHg for 48 hours to 2 weeks while resting during the day
- You are able to follow the trial plan and give informed consent (or have someone able to consent for you)
- You are not currently on long-term breathing support like home NIV or CPAP
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares two breathing devices (CPAP and NIV) for people with both COPD and sleep apnea who recently needed breathing help in the hospital. The goal is to see which device works better at preventing future breathing emergencies.
This trial compares different breathing strategies for people with COPD who still have high carbon dioxide levels in their blood a few weeks after a severe flare-up. The goal is to find the best way to help you breathe easier and improve your oxygen levels.
This trial tests whether home telemonitoring combined with a breathing machine (non-invasive ventilation) can help people with advanced COPD and persistently high carbon dioxide levels. It aims to improve care and reduce hospital visits.
This trial tests whether a device that helps you breathe during exercise can improve how long you can keep going. It aims to help people with severe COPD who have too much carbon dioxide in their blood or who get easily exhausted.
This trial tests whether using a non-invasive ventilator (a breathing machine with a mask) at home can help people with severe COPD who have high carbon dioxide levels in their blood. It aims to improve breathing and reduce the need for hospital visits.
This trial compares two types of breathing support you can use at home—high-flow nasal cannula (a gentle flow of warm, moist air through the nose) and noninvasive ventilation (a mask that helps push air into your lungs). The goal is to see which one works better for people with stable COPD and high carbon dioxide levels in their blood.
Hear when a new COPD Exacerbation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.