Testing breathing support needs in COPD with high CO2
Part of Lungs & breathing clinical trials.
This trial studies how different breathing support strategies affect people with COPD who have high carbon dioxide (CO2) in their blood. It may help care teams choose safer respiratory support after a breathing machine is stopped.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have COPD that has been graded as GOLD C or D
- Your lung test shows poor airflow (FEV1 under 65%)
- Your blood gases show high CO2: pH is low (below 7.35) and CO2 is high (PaCO2 at least 45 mmHg), and you were on a breathing ventilator for over 24 hours
- After stopping the breathing machine, your blood gases stay with pH above 7.35 and CO2 above 45 mmHg for 48 hours to 2 weeks while resting during the day
- You are able to follow the trial plan and give informed consent (or have someone able to consent for you)
- You are not currently on long-term breathing support like home NIV or CPAP
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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