Chemoradiation with two cisplatin or carboplatin plans for nasopharyngeal cancer
Part of Cancer, Ear, nose & throat, Mouth & dental clinical trials.
This Phase 3 trial compares two chemotherapy-and-radiation combinations (cisplatin-based vs carboplatin-based) for locally advanced nasopharyngeal cancer that has not spread to distant organs. It may help researchers find which plan works best while balancing safety and effectiveness.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have newly diagnosed non-keratinizing nasopharyngeal cancer (not a keratinizing or certain other types).
- Your cancer stage is locally advanced (T3–T4 with lymph nodes N2–N3) and there is no spread to distant organs (M0).
- You are between 18 and 64 years old, and you are not pregnant or breastfeeding.
- You can do usual daily activities fairly well (Karnofsky score above 70).
- Your blood, liver, and kidney tests are within required ranges (including kidney function clearance ≥60).
- You have not had prior radiation or chemotherapy/surgery for the main tumor or nearby nodes (except certain limited exceptions), and you have no serious uncontrolled health problems that could make treatment too risky.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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