Comparing surgery with and without pre-surgery treatment for mouth or throat cancer
Part of Cancer, Ear, nose & throat, Mouth & dental clinical trials.
This study compares doing surgery alone versus giving a combination of focused radiation (SBRT) and chemotherapy with an immunotherapy drug before surgery for mouth or throat cancer. The goal is to see if the pre-surgery treatment makes the cancer shrink more and improves outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a newly diagnosed cancer of the mouth or throat (not linked to HPV) that has not been treated yet.
- The cancer is at a locally advanced stage (meaning it's large or has spread to nearby tissues or lymph nodes, but hasn't spread to distant organs).
- You are between 18 and 75 years old.
- You are in generally good health—able to care for yourself and have adequate organ function.
- You agree to use effective birth control if you or your partner could become pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a new immunotherapy drug (tirellizumab) combined with chemotherapy before surgery for early-stage oral cancer. It aims to see if this combination can help shrink the tumor and improve outcomes.
This trial tests whether adding a type of radiation therapy (SBRT) to chemoimmunotherapy before surgery helps people with advanced mouth or throat cancer. The goal is to see if this combination can shrink tumors more effectively and improve outcomes.
This trial tests combining radiation therapy with immunotherapy and chemotherapy before surgery for advanced oral or throat cancer. The goal is to see if this approach can shrink the tumor and improve treatment outcomes.
This Phase 2 trial tests giving the immunotherapy drug sintilimab before surgery, along with fewer chemotherapy cycles. The goal is to shrink or control oral or throat squamous cell cancers while keeping side effects lower, before the tumor is removed.
This trial compares giving immunotherapy alone versus immunotherapy plus focused radiation before surgery for head and neck cancer. The goal is to see if adding radiation helps shrink the tumor and improve outcomes.
This Phase 3 trial compares two treatment plans for stage III/IVA head and neck squamous cell cancer (HNSCC). One plan uses an immune drug with chemotherapy before surgery; the other goes straight to surgery first, to see which approach works better.
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