SBRT plus chemoimmunotherapy before surgery for advanced mouth or throat cancer
Part of Cancer, Ear, nose & throat, Mouth & dental clinical trials.
This trial tests if giving a short course of radiation (SBRT) along with chemotherapy and an immunotherapy drug before surgery can improve outcomes for people with advanced mouth or throat cancer that is not caused by HPV. It's designed for patients whose tumors can be surgically removed and who haven't had prior cancer treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a type of head and neck cancer (mouth or back of throat) that hasn't been treated yet and is at a locally advanced stage (Stage III or IVA).
- You are between 18 and 75 years old.
- Your overall health is good, meaning you can take care of yourself (ECOG score 0 or 1).
- Your organs (like kidney, liver) are working well enough for the treatment.
- You have not had certain immune-related diseases (like lupus), active tuberculosis, or HIV, and you are not pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether adding targeted radiation (SBRT) to a combination of chemotherapy and immunotherapy before surgery can improve outcomes for people with advanced mouth or throat cancer. It aims to shrink the tumor more effectively before removal.
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