Clin2
NCT04284839Possibly a fitRecruiting

Blood thinner pills vs warfarin after heart surgery

Bleeding Post Cardiac SurgeryIndication for Anticoagulation

Treatments studied

Part of Heart & circulation clinical trials.

This trial compares two ways to prevent blood clots after open heart surgery: a “direct oral” blood thinner pill versus warfarin (a vitamin K antagonist). It may help find the safest and most effective option for people who develop atrial fibrillation after surgery.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
3,500 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older
  • You had open heart surgery within the last 10 days
  • You have atrial fibrillation that requires a blood thinner (before or after surgery)
  • You can (or a legal decision-maker can) give informed consent
  • You are not expected to miss follow-up visits or testing

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT04045665Recruiting· Phase 3
Blood thinner vs usual care for new heart rhythm after bypass surgery

This trial tests whether using a blood thinner in people with new, temporary atrial fibrillation after CABG (heart bypass surgery) can reduce harmful outcomes compared with standard treatment. It may help prevent stroke or other complications if your rhythm problem fits the trial’s timing and risk profile.

Little Rock, Arkansas
NCT07011095Not yet recruiting· Early Phase 1
Blood thinner choice after a stroke while on a DOAC

This trial compares two types of blood thinners (DOACs like apixaban or rivaroxaban, and warfarin) to see which works better for people who have a stroke while taking a DOAC. The goal is to find the safest and most effective option to prevent another stroke.

NCT06401616Recruiting· Phase 4
Stopping blood thinners after heart surgery for atrial fibrillation

This trial tests whether it is safe for patients with atrial fibrillation to stop taking blood thinners after they have had heart surgery, including closure of the left atrial appendage. The goal is to see if these patients can avoid long-term medication without increasing the risk of stroke.

Copenhagen, Capital Region
NCT07434661Not yet recruiting· Phase 3
Apixaban vs warfarin after heart valve surgery for atrial fibrillation

This study compares two blood thinners, apixaban (Eliquis) and warfarin, for people with atrial fibrillation who have just had heart valve surgery (repair or biological replacement). The goal is to see which medicine works better at preventing strokes and blood clots in the first three months after surgery.

Novosibirsk
NCT04258488Recruiting· Phase 4
Blood thinner pill vs warfarin after mechanical aortic valve

This study compares a blood thinner pill (a factor Xa inhibitor) with warfarin (vitamin K antagonist) in people who have had a mechanical aortic valve replacement. It looks at which option works better and is safer over the long term.

Bucheon-si
NCT05782270Recruiting· Phase 4
Blood thinner medicines after bypass surgery with artery unblocking

This trial studies which blood-thinning medicine combination is safest and most helpful after coronary bypass surgery combined with a procedure to unblock the artery (endarterectomy). It focuses on preventing dangerous blood clots while also avoiding excess bleeding.

Beijing, Beijing Municipality

Hear when a new Bleeding Post Cardiac Surgery trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.